Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Maria Santos Martinez Martinez"'
Autor:
Julia Beveridge, Eric Tran, Girdhar Singh Deora, Fei Huang, Yuzhi Wang, Kieran Stockton, Ignacio Cotillo, Maria Santos Martinez Martinez, Silvia Gonzalez, Pablo Castañeda, Julian Sherman, Ana Rodriguez, Albane Kessler, Jonathan B. Baell
Publikováno v:
Journal of Medicinal Chemistry. 66:1522-1542
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62bc4c31ae9891c48de5871c379a4910
https://doi.org/10.1021/acs.jmedchem.2c01725
https://doi.org/10.1021/acs.jmedchem.2c01725
Autor:
Dana M. Klug, Nelly El-Sakkary, Cristina Bosch-Navarrete, Rosario Diaz-Gonzalez, Gloria Ceballos-Pérez, Guiomar Pérez-Moreno, Jeremiah D. Momper, Carlos Cordon-Obras, Francisco Gamarro, Dolores Gonzalez Pacanowska, Maria Santos Martinez-Martinez, Lori Ferrins, Conor R. Caffrey, Eftychia M. Mavrogiannaki, Katherine C. Forbes, Raquel García-Hernández, Claudia Gómez-Liñán, Miguel Navarro, Andreu Saura, Luis M. Ruiz-Pérez, Pilar Manzano, Ali Syed, Lisseth Silva, Michael P. Pollastri
Publikováno v:
J Med Chem
Neglected tropical diseases such as human African trypanosomiasis (HAT) are prevalent primarily in tropical climates and among populations living in poverty. Historically, the lack of economic incentive to develop new treatments for these diseases ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9937aba3a31ba3131cffe3becb644f09
https://doi.org/10.1021/acs.jmedchem.1c00674
https://doi.org/10.1021/acs.jmedchem.1c00674
Autor:
Henok Asfaw, Katja Laqua, Anna Maria Walkowska, Fraser Cunningham, Maria Santos Martinez-Martinez, Juan Carlos Cuevas-Zurita, Lluís Ballell-Pages, Peter Imming
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176088 (2017)
Wollamide B is a cationic antimycobacterial cyclohexapeptide that exhibits activity against Mycobacterium bovis (M. bovis) (IC50 of 3.1 μM). Aiming to define its structural activity relationship (SAR), optimizing potency and pharmacokinetic properti
Externí odkaz:
https://doaj.org/article/eea2060467404578b60d49862c64ef37
Autor:
Pilar Manzano, Maria Santos Martinez-Martinez, Miguel Navarro, Michael P. Pollastri, Naresh Gunaganti, Gloria Ceballos-Pérez, Kirsten Gillingwater, Domingo I. Rojas-Barros, Rosario Diaz-Gonzalez, Baljinder Singh
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
J Med Chem
instname
J Med Chem
Human African trypanosomiasis (HAT), or sleeping sickness, is caused by the protozoan parasite Trypanosoma brucei and transmitted through the bite of infected tsetse flies. The disease is considered fatal if left untreated. To identify new chemotypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8b3af0fa2337d349ba09302701f4b6
https://doi.org/10.1021/acs.jmedchem.0c01017
https://doi.org/10.1021/acs.jmedchem.0c01017
Autor:
Pradipsinh K. Rathod, Margaret A. Phillips, Michael J. Palmer, Sreekanth Kokkonda, Farah El Mazouni, John H. White, David Waterson, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Maria Santos Martinez-Martinez, Helena Barker, Leticia Huertas-Valentin, Jenna McLaren, Santiago Ferrer, Jeremy N. Burrows, Shatrughan P Shahi, Karen L. White, Maria Jose Lafuente-Monasterio, Dave Matthews, Gong Chen, Francis C. K. Chiu, David M. Shackleford, Elly Crighton, Kasiram Katneni, Xiaoyi Deng, Sergio Wittlin, Diana R. Tomchick, Susan A. Charman, Rajesh Chittimalla
Publikováno v:
J Med Chem
Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c8bca2acecd67955624d5564e79816
https://doi.org/10.1021/acs.jmedchem.0c00311
https://doi.org/10.1021/acs.jmedchem.0c00311
Autor:
Paco de Dios-Anton, Chun-wa Chung, Elena Jimenez, Maria Santos Martinez-Martinez, Fraser Cunningham, Mythily Vimal, Ana Guardia, Raquel Fernandez-Menendez, Arancha Pérez, Jaime Escribano, Jorge Esquivias, Robert H. Bates, María José Rebollo-López, Verónica Sousa-Morcuende, Monica Cacho, Joaquín Rullas, Eva Maria Lopez-Roman, Cristina Rivero, Margaret Neu, Leticia Huertas Valentín
Publikováno v:
ACS Infectious Diseases. 6:1098-1109
In the course of optimizing a novel indazole sulfonamide series that inhibits β-ketoacyl-ACP synthase (KasA) of Mycobacterium tuberculosis, a mutagenic aniline metabolite was identified. Further lead optimization efforts were therefore dedicated to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4ffbcdf78173cbc7773be3376915d1
https://doi.org/10.1021/acsinfecdis.9b00493
https://doi.org/10.1021/acsinfecdis.9b00493
Autor:
Patricia Santa Teresa, Eduard Argudo, Elena Sandoval, Camilo Bonilla, Luis Chiscano, Ricardo Gimeno, Maria Santos Martinez-Martinez, Gloria Renedo, Héctor Villanueva-Fernández, Manuel Alfonso García, María Paz Fuset, Maria Victoria Boado, Pablo Coto Millán, Roberto Roncon-Albuquerque, Jorge Duerto, Pablo Ruiz de Gopegui, Sergi Martinez, Phillip Fortuna, Stephani María Luna, Vanesa Gómez, Daniel Vidal Pérez, Joaquín Colomina, Jordi Riera, Pablo Blanco-Schweizer, Pedro Eduardo Silva, Pilar Ricart, Alfredo González-Pérez, Helena Pérez-Chomón, Roberto Voces, Aaron Blandino Ortiz, Jose E. Naranjo, Emilio Rodríguez-Ruiz, Marta Garcia, Ana Paula Vaz, J. Veganzones, Sara Alcántara, Carlos Albacete
Publikováno v:
EUROPEAN RESPIRATORY JOURNAL
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
The European Respiratory Journal
article-version (AM) Accepted Manuscript
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
The European Respiratory Journal
article-version (AM) Accepted Manuscript
Series describing the evolution of patients with severe acute respiratory distress syndrome (ARDS) secondary to COVID-19 and supported with extracorporeal membrane oxygenation (ECMO) during the first wave of the pandemic have reported mortalities ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fff7299cf35425443b7b7f777453473
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=15305
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=15305
Autor:
Jaime de Mercado, Ha Thanh Tuyen, Lluis Ballel, Saul Tzipori, Molly C. McCloskey, Samuel L.M. Arnold, Adolfo García-Perez, Phat Voong Vinh, Judd L. Walson, Benson Singa, Nhu Tran Do Hoang, Beatriz Urones, Stephen Baker, Alan Price, Patricia B Pavlinac, Denise Dayao, Alvaro Cortés, Elena Fernández Alvaro, Cristina de Cozar, Maria Santos Martinez-Martinez, Shareef Shaheen
Diarrhoea remains one of the leading causes of childhood mortality globally. Recent epidemiological studies conducted in low-middle income countries (LMICs) identified Shigella spp. as the first and second most predominant agent of dysentery and mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7abb2fc65bd1314924f89a7591b44207
https://doi.org/10.21203/rs.3.rs-310608/v1
https://doi.org/10.21203/rs.3.rs-310608/v1
Autor:
Roland A. Cooper, Thijs Beuming, Philip J. Rosenthal, Jeremie Vendome, Laura A. Kirkman, Akinori Toita, Ryoma Hara, John Ginn, Annie Leung, Maria Jose Lafuente-Monasterio, Takafumi Yukawa, Wenhu Zhan, Gang Lin, Kazuyoshi Aso, Patrick K Tumwebaze, Mayako Michino, Carl Nathan, Kenjiro Sato, Hao Zhang, Yi J. Liu, Toshihiro Imaeda, Maria Santos Martinez-Martinez, Peter T. Meinke, Rei Okamoto, Sevil Chelebieva, Tzu-Tshin Wong
Publikováno v:
Angew Chem Int Ed Engl
Plasmodium falciparum proteasome (Pf20S) inhibitors are active against Plasmodium at multiple stages - erythrocytic stages, gametocyte stages, liver stages and gamete activation, indicating that selective Pf20S inhibitors possess the potential to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee3fca82d9f5dad855747f989475a5d
https://pubmed.ncbi.nlm.nih.gov/33433953
https://pubmed.ncbi.nlm.nih.gov/33433953
Autor:
Miguel Navarro, Quillon J. Simpson, Travis J. DeLano, Maria Santos Martinez-Martinez, Raquel García-Hernández, Rosario Diaz-Gonzalez, Westley Tear, Guiomar Pérez-Moreno, William G. Devine, Lori Ferrins, Dolores González-Pacanowska, Luis M. Ruiz-Pérez, Melanie G. Fritsche, Katherine M. Schneider, Michael P. Pollastri, Francisco Gamarro, John K. Fisher, Cristina Bosch-Navarrete, Pilar Manzano-Chinchon, Vivian Hilborne, Dana M. Klug, Raeann M. Dalton, Gloria Ceballos-Pérez, Eftychia M. Mavrogiannaki, Melissa J. Buskes
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
RSC Med Chem
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
RSC Med Chem
Human African trypanosomiasis is a neglected tropical disease (NTD) that is fatal if left untreated. Although approximately 13 million people live in moderate- to high-risk areas for infection, current treatments are plagued by problems with safety,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c419df9071d8f28b3bdefbdbcc538de7
http://hdl.handle.net/10261/246477
http://hdl.handle.net/10261/246477