Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Maria Sakurai"'
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108893- (2024)
Summary: α-Synuclein and LRRK2 are associated with both familial and sporadic Parkinson’s disease (PD), although the mechanistic link between these two proteins has remained elusive. Treating cells with lysosomotropic drugs causes the recruitment
Externí odkaz:
https://doaj.org/article/2dc29bb247bc4fb6b0e29398efefee35
Autor:
Tomoki Kuwahara, Kai Funakawa, Tadayuki Komori, Maria Sakurai, Gen Yoshii, Tomoya Eguchi, Mitsunori Fukuda, Takeshi Iwatsubo
Publikováno v:
Neurobiology of Disease, Vol 145, Iss , Pp 105081- (2020)
Leucine-rich repeat kinase 2 (LRRK2), the major causative gene product of autosomal-dominant Parkinson's disease, is a protein kinase that phosphorylates a subset of Rab GTPases. Since pathogenic LRRK2 mutations increase its ability to phosphorylate
Externí odkaz:
https://doaj.org/article/d3f3e8da07684b209cf729edfe003571
Rab proteins are small GTPases that regulate a myriad of intracellular membrane trafficking events. Rab29 is one of the Rab proteins phosphorylated by leucine-rich repeat kinase 2 (LRRK2), a Parkinson’s disease-associated kinase. Recent studies sug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd3a2b242b499824b36c074a4d29f5ef
https://doi.org/10.1101/2022.09.26.509472
https://doi.org/10.1101/2022.09.26.509472
Autor:
Maria, Sakurai, Tomoki, Kuwahara
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2322
Leucine-rich repeat kinase 2 (LRRK2) is a causative gene product of autosomal-dominant Parkinson's disease and has been shown to play a role in lysosomal regulation. We have previously shown that endogenous LRRK2 recruited its substrates Rab8a and Ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b54ecb40447e1a0c80d98a68fcb32a5
https://pubmed.ncbi.nlm.nih.gov/34043193
https://pubmed.ncbi.nlm.nih.gov/34043193
Autor:
Maria Sakurai, Tomoki Kuwahara
Publikováno v:
Methods in Molecular Biology ISBN: 9781071614945
Leucine-rich repeat kinase 2 (LRRK2) is a causative gene product of autosomal-dominant Parkinson's disease and has been shown to play a role in lysosomal regulation. We have previously shown that endogenous LRRK2 recruited its substrates Rab8a and Ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ed9066629a83565eb0ca1d16f65efc6
https://doi.org/10.1007/978-1-0716-1495-2_7
https://doi.org/10.1007/978-1-0716-1495-2_7
Autor:
Maria Sakurai, Gen Yoshii, Tomoya Eguchi, Takeshi Iwatsubo, Tadayuki Komori, Kai Funakawa, Mitsunori Fukuda, Tomoki Kuwahara
Publikováno v:
Neurobiology of Disease, Vol 145, Iss, Pp 105081-(2020)
Leucine-rich repeat kinase 2 (LRRK2), the major causative gene product of autosomal-dominant Parkinson’s disease, is a protein kinase that phosphorylates a subset of Rab GTPases. Since pathogenic LRRK2 mutations increase its ability to phosphorylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3647f9711c5879cbc604995e44176d2f
https://pubmed.ncbi.nlm.nih.gov/32919031
https://pubmed.ncbi.nlm.nih.gov/32919031
Autor:
Shin-ichiro Yoshimura, Mitsunori Fukuda, Tomoya Eguchi, Tetta Fujimoto, Masato Koike, Tadayuki Komori, Akihiro Harada, Maria Sakurai, Takeshi Iwatsubo, Tomoki Kuwahara, Genta Ito
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance LRRK2, a protein kinase related to Parkinson’s disease, is implicated in the maintenance of lysosomes, and a subset of Rab GTPases has been identified as bona fide substrates of LRRK2. Here, we reveal a key stress-responsive pathway co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ffeec63ce4cff9d2d4453206644e79
http://europepmc.org/articles/PMC6166828
http://europepmc.org/articles/PMC6166828
Autor:
Tetta Fujimoto, Tomoya Eguchi, Maria Sakurai, Takeshi Iwatsubo, Tomoki Kuwahara, Tadayuki Komori
Publikováno v:
Biochemical and biophysical research communications. 495(2)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the major genetic cause of autosomal-dominantly inherited Parkinson's disease. LRRK2 is implicated in the regulation of intracellular trafficking, neurite outgrowth and PD risk in connection with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d7c7db38eb72246495a32b323423f9
https://pubmed.ncbi.nlm.nih.gov/29223392
https://pubmed.ncbi.nlm.nih.gov/29223392
Autor:
Tomoya Eguchi, Tomoki Kuwahara, Maria Sakurai, Tadayuki Komori, Tetta Fujimoto, Takeshi Iwatsubo, Genta Ito, Shin-ichiro Yoshimura, Akihiro Harada, Mitsunori Fukuda, Masato Koike
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 9/25/2018, Vol. 115 Issue 39, pE9115-E9124, 10p