Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Maria Sadiq"'
Autor:
Daniela Presa, Syed A. Khurram, Amir Z. A. Zubir, Sneha Smarakan, Patricia A. Cooper, Goreti R. Morais, Maria Sadiq, Mark Sutherland, Paul M. Loadman, James McCaul, Steven D. Shnyder, Laurence H. Patterson, Klaus Pors
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Epidemiological studies have shown that head and neck cancer (HNC) is a complex multistage process that in part involves exposure to a combination of carcinogens and the capacity of certain drug-metabolising enzymes including cytochrome P450
Externí odkaz:
https://doaj.org/article/4ea9b86b01fd4ec18d301c0d665c1e69
Autor:
Muhammad Arshad, Fawwad Jaskani, Muhammad Sabri, Fatima Ashraf, Muhammad Farhan, Maria Sadiq, Hammad Raza
Publikováno v:
EAI Endorsed Transactions on Internet of Things, Vol 7, Iss 26 (2022)
The cell phone is assuming a crucial job in present day life. It offers types of assistance and applications, for example, location tracking, medical applications, and human activity examination. All android smartphones have motion sensors i.e. Accel
Externí odkaz:
https://doaj.org/article/78b54a4ee28c460d91831c212caf56af
Autor:
Luca Quattrini, Maria Sadiq, Giovanni Petrarolo, Norman J. Maitland, Fiona M. Frame, Klaus Pors, Concettina La Motta
Publikováno v:
Biomedicines, Vol 8, Iss 12, p 569 (2020)
Prostate cancer represents the most common malignancy diagnosed in men, and is the second-leading cause of cancer death in this population. In spite of dedicated efforts, the current therapies are rarely curative, requiring the development of novel a
Externí odkaz:
https://doaj.org/article/b8594ba6e5654b259ad55760883fe350
Autor:
Ali I. M. Ibrahim, Elisabet Batlle, Smarakan Sneha, Rafael Jiménez, Raquel Pequerul, Xavier Parés, Till Rüngeler, Vibhu Jha, Tiziano Tuccinardi, Maria Sadiq, Fiona Frame, Norman J. Maitland, Jaume Farrés, Klaus Pors
Publikováno v:
Journal of Medicinal Chemistry. 65:3833-3848
Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer and considered a potential target for therapeutic intervention. 4-(Diethylamino)benzaldehyde (DEAB) has been extensively reported as a pan-inhibitor of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afaeea21d5090735ad972cdce93e8fa
https://doi.org/10.1021/acs.jmedchem.1c01367
https://doi.org/10.1021/acs.jmedchem.1c01367
Autor:
Laurence H. Patterson, James McCaul, Sneha Smarakan, Daniela Presa, Klaus Pors, Amir Zaki Abdullah Zubir, Syed Ali Khurram, Maria Sadiq, Paul M. Loadman, Mark Sutherland, Patricia A. Cooper, Goreti Ribeiro Morais, Steven D. Shnyder
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Epidemiological studies have shown that head and neck cancer (HNC) is a complex multistage process that in part involves exposure to a combination of carcinogens and the capacity of certain drug-metabolising enzymes including cytochrome P450 (CYP) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8699e8b1784751673081ee4c59f249c
https://doaj.org/article/4ea9b86b01fd4ec18d301c0d665c1e69
https://doaj.org/article/4ea9b86b01fd4ec18d301c0d665c1e69
Autor:
Elisabet Batlle Rocafort, Ali I. Ibrahim, Maria Sadiq, Sneha Smarakan, Vibhu Jha, Tiziano Tuccinardi, Fiona Frame, Norman Maitland, Rafael Jiménez Aguilar, Raquel Pequerul Pavón, Xavier Parés Casampera, Goreti Ribeiro Morais, Jaume Farrés Vicen, Klaus Pors
Publikováno v:
Cancer Research. 82:1820-1820
The human aldehyde dehydrogenases (ALDHs) play a major role in the metabolism of endogenous compounds and xenobiotics. Deregulation of ALDHs have implications in a number of cancers and their elevated expression in cancer stem cells (CSCs) have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3da5b50c5786c6077e9a7b811db88467
https://doi.org/10.1158/1538-7445.am2022-1820
https://doi.org/10.1158/1538-7445.am2022-1820
Autor:
Concettina La Motta, Fiona M. Frame, Norman J. Maitland, Maria Sadiq, Giovanni Petrarolo, Luca Quattrini, Klaus Pors
Publikováno v:
Biomedicines
Volume 8
Issue 12
Biomedicines, Vol 8, Iss 569, p 569 (2020)
Volume 8
Issue 12
Biomedicines, Vol 8, Iss 569, p 569 (2020)
Prostate cancer represents the most common malignancy diagnosed in men, and is the second-leading cause of cancer death in this population. In spite of dedicated efforts, the current therapies are rarely curative, requiring the development of novel a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e1cc017990734b2fabb03976489cd7
http://europepmc.org/articles/PMC7761903
http://europepmc.org/articles/PMC7761903
Autor:
Roger M. Phillips, Richard T. Wheelhouse, Christopher Dunnill, Nikolaos T. Georgopoulos, Steve D. Shnyder, Efstathia Baronou, Ayse Latif, Simon J. Allison, Maria Sadiq, Ian J. Stratford, Charlotte E. Willans, Samantha L. Shepherd, Patricia A. Cooper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525ab33160b9b3d6aefd6bb98ec94c97
Autor:
Marcella Sini, Klaus Pors, Omair Sadiq, Marie Wiltshire, Rachel J. Errington, Maria Dolors Pujol, Goreti Ribeiro Morais, Maria Sadiq, Enric Lizano, Laura Cosentino
Structural features from the anticancer prodrug nemorubicin (MMDX) and the DNA-binding molecule DRAQ5™ were used to prepare anthraquinone-based compounds, which were assessed for their potential to interrogate cytochrome P450 (CYP) functional activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1749cce0f040b5fb3d6db595563cea
Autor:
Kamyar Afarinkia, Lina Elsalem, Laurence H. Patterson, Paul M. Loadman, Maria Sadiq, Victoria Vinader, Mark Searcey, Klaus Pors, Mengying Huang, Mark Sutherland, Steven D. Shnyder, Hongjuan Cui
Publikováno v:
MedChemComm. 6:187-191
A deactivated alkene precursor (IC50 = 81 μM) to the azinomycin epoxide natural product can be bioactivated by several cytochromes P450 (CYP) to generate antiproliferative metabolites with increased potency (IC50 = 1–30 μM) in CHOwt cells. CYP1A1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866e3dc28e6a4c00d2e5ee6356bb8476
https://doi.org/10.1039/c4md00411f
https://doi.org/10.1039/c4md00411f