Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes

Autor: Catarina Dias, João P. Pais, Rafael Nunes, Maria-Teresa Blázquez-Sánchez, Joaquim T. Marquês, Andreia F. Almeida, Patrícia Serra, Nuno M. Xavier, Diogo Vila-Viçosa, Miguel Machuqueiro, Ana S. Viana, Alice Martins, Maria S. Santos, Ana Pelerito, Ricardo Dias, Rogério Tenreiro, Maria C. Oliveira, Marialessandra Contino, Nicola A. Colabufo, Rodrigo F. M. de Almeida, Amélia P. Rauter

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Bacillus anthracis causes the infectious disease anthrax. Here, the authors synthesized deoxy glycosides that are effective against B. anthracis and related bacteria and found that these amphiphilic compounds kill bacteria via an unusual mechanism of

Externí odkaz: https://doaj.org/article/158158d4523442a69f2881aae2aca7d4

Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance

Autor: Susana Cardoso, Renato X. Santos, Sónia C. Correia, Cristina Carvalho, Maria S. Santos, Inês Baldeiras, Catarina R. Oliveira, Paula I. Moreira

Publikováno v: Neurobiology of Disease, Vol 49, Iss , Pp 1-12 (2013)

Intensive insulin therapy can prevent or slow the progression of long-term diabetes complications but, at the same time, it increases the risk for episodes of severe hypoglycemia. In our study, we used a protocol intended to mimic the levels of blood

Externí odkaz: https://doaj.org/article/91ea41c3b5c7490983b4680b04571e00

Insulin protects against amyloid β-peptide toxicity in brain mitochondria of diabetic rats

Autor: Paula I. Moreira, Maria S. Santos, Cristina Sena, Raquel Seiça, Catarina R. Oliveira

Publikováno v: Neurobiology of Disease, Vol 18, Iss 3, Pp 628-637 (2005)

This study compared the status of brain mitochondria isolated from 12-week streptozotocin (STZ)-diabetic rats versus STZ-diabetic animals treated with insulin during a period of 4 weeks. Brain mitochondria isolated from 12-week citrate (vehicle)-trea

Externí odkaz: https://doaj.org/article/346b9b687b2244fdafab8768953332d4

Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction

Autor: João D. Martins, Antonio Moreno, Cun Li, Susana P. Pereira, Laura A. Cox, Maria S. Santos, Paulo J. Oliveira, Ludgero C. Tavares, Ana I. Duarte, Peter W. Nathanielsz, Teresa Cunha-Oliveira, Alina Maloyan, Inês Baldeiras, Mark J. Nijland

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Clin Sci (Lond)

Poor maternal nutrition in pregnancy affects fetal development, predisposing offspring to cardiometabolic diseases. The role of mitochondria during fetal development on later-life cardiac dysfunction caused by maternal nutrient reduction (MNR) remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9f850b9d63535cd468caa672348b17
https://doi.org/10.1042/cs20201339

Insulin as a bridge between type 2 diabetes and Alzheimer disease – How anti-diabetics could be a solution for dementia

Autor: Inês eSebastião, Emanuel eCandeias, Maria S Santos, Catarina R. Oliveira, Paula I Moreira, Ana I Duarte

Publikováno v: Frontiers in Endocrinology, Vol 5 (2014)

Type 2 diabetes (T2D) and Alzheimer disease (AD) are two major health issues nowadays. T2D is an ever increasing epidemic, affecting millions of elderly people worldwide, with major repercussions in the patients’ daily life. This is mostly due to i

Externí odkaz: https://doaj.org/article/9b09647aba8d4d9d9fe0892363dc44fc