Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Maria Ruzzene"'
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-5 (2021)
Abstract CK2 is a protein kinase involved in several human diseases (ranging from neurological and cardiovascular diseases to autoimmune disorders, diabetes, and infections, including COVID-19), but its best-known implications are in cancer, where it
Externí odkaz:
https://doaj.org/article/1c83afc10fd14c62b2aade8c5b174e0c
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-20 (2021)
Abstract CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of substrates, controls several signaling pathways, and is implicated in a plethora of human diseases. Its best documented role is in cancer, where it regul
Externí odkaz:
https://doaj.org/article/4e2233794ece4f208ef8e20378e774a9
Autor:
Simone Fabbian, Gabriele Giachin, Massimo Bellanda, Christian Borgo, Maria Ruzzene, Giacomo Spuri, Ambra Campofelice, Laura Veneziano, Marcella Bonchio, Mauro Carraro, Roberto Battistutta
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
CK2 is a Ser/Thr protein kinase involved in many cellular processes such as gene expression, cell cycle progression, cell growth and differentiation, embryogenesis, and apoptosis. Aberrantly high CK2 activity is widely documented in cancer, but the e
Externí odkaz:
https://doaj.org/article/f0ac466cbae14ad29dbd0b914b9bdad7
Autor:
Christian Borgo, Maria Ruzzene
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-15 (2019)
Abstract Drug resistance represents the major reason of pharmacological treatment failure. It is supported by a broad spectrum of mechanisms, whose molecular bases have been frequently correlated to aberrant protein phosphorylation. CK2 is a constitu
Externí odkaz:
https://doaj.org/article/2699fbfe28e44ddcbabb894db8296c37
Autor:
Estefania Alcaraz, Jordi Vilardell, Christian Borgo, Eduard Sarró, Maria Plana, Oriano Marin, Lorenzo A Pinna, José R Bayascas, Anna Meseguer, Mauro Salvi, Emilio Itarte, Maria Ruzzene
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227340 (2020)
The PI3K/Akt pathway is interconnected to protein kinase CK2, which directly phosphorylates Akt1 at S129. We have previously found that, in HK-2 renal cells, downregulation of the CK2 regulatory subunit β (shCK2β cells) reduces S129 Akt phosphoryla
Externí odkaz:
https://doaj.org/article/69543d1d78a64740811782633ddbd0bf
Autor:
Mattia Vicario, Ginevra Zanni, Francesca Vallese, Filippo Santorelli, Alessandro Grinzato, Domenico Cieri, Paola Berto, Martina Frizzarin, Raffaele Lopreiato, Francesco Zonta, Stefania Ferro, Michele Sandre, Oriano Marin, Maria Ruzzene, Enrico Bertini, Giuseppe Zanotti, Marisa Brini, Tito Calì, Ernesto Carafoli
Publikováno v:
Neurobiology of Disease, Vol 115, Iss , Pp 157-166 (2018)
The fine regulation of intracellular calcium is fundamental for all eukaryotic cells. In neurons, Ca2+ oscillations govern the synaptic development, the release of neurotransmitters and the expression of several genes. Alterations of Ca2+ homeostasis
Externí odkaz:
https://doaj.org/article/e150d2b6b39046888fbd11d8fd4b98bd
Autor:
Francesca Zonta, Christian Borgo, Camila Paz Quezada Meza, Ionica Masgras, Andrea Rasola, Mauro Salvi, Lorenzo A. Pinna, Maria Ruzzene
Publikováno v:
Cells, Vol 10, Iss 1, p 181 (2021)
CK2 is a Ser/Thr protein kinase overexpressed in many cancers. It is usually present in cells as a tetrameric enzyme, composed of two catalytic (α or α’) and two regulatory (β) subunits, but it is active also in its monomeric form, and the speci
Externí odkaz:
https://doaj.org/article/25324a922bfd41e3bf4eb655bf940954
Autor:
Jordi Vilardell, Cristina Girardi, Oriano Marin, Giorgio Cozza, Lorenzo A Pinna, Maria Ruzzene
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193479 (2018)
CK2 is a pleiotropic S/T protein kinase (formerly known as casein kinase 2) which is attracting increasing interest as therapeutic target, and the identification of its substrates is a crucial step in determining its involvement in different patholog
Externí odkaz:
https://doaj.org/article/743db528b56042ce91e2ddbb21a5de47
Autor:
Laura Ferrer-Font, Lucia Villamañan, Nuria Arias-Ramos, Jordi Vilardell, Maria Plana, Maria Ruzzene, Lorenzo A. Pinna, Emilio Itarte, Carles Arús, Ana Paula Candiota
Publikováno v:
Pharmaceuticals, Vol 10, Iss 1, p 24 (2017)
Glioblastoma (GBM) causes poor survival in patients even with aggressive treatment. Temozolomide (TMZ) is the standard chemotherapeutic choice for GBM treatment but resistance always ensues. Protein kinase CK2 (CK2) contributes to tumour development
Externí odkaz:
https://doaj.org/article/e670bbaecb9a42958d9d85d51579d85e
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89176 (2014)
Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival, whose investigation has been hampered by the lack of specific inhibitors able to dissect its cellular functions. SB203580, a p38 MAP kin
Externí odkaz:
https://doaj.org/article/9f305def2de64cbbae738c68cd18ff17