Výsledky vyhledávání - "Maria Rosaria Delogu"

Role of the nitric oxide/cyclic GMP pathway and ascorbic acid in 3-morpholinosydnonimine (SIN-1)-induced increases in dopamine secretion from PC12 cells. A microdialysis in vitro study

Autor: Pier Andrea Serra, Maria Rosaria Delogu, Rossana Migheli, Maddalena Miele, Maria Grazia Taras, Giovanni Esposito, Maria Pina Mura, Gaia Giovanna Maria Rocchitta, Egidio Miele, Maria Speranza Desole

Publikováno v: Neuroscience Letters. 353:5-8

We showed previously, using in vitro microdialysis, that activation of the nitric oxide (NO)/cyclic GMP pathway was the underlying mechanism of exogenous NO-induced dopamine (DA) secretion from PC12 cells. In this study, infusion of the potential per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6a3e023468460d5a5c47302f5dfc5d
https://doi.org/10.1016/j.neulet.2003.07.022

Zobrazit plný text záznamu

Role of the nitric oxide/cyclic GMP pathway and extracellular environment in the nitric oxide donor-induced increase in dopamine secretion from PC12 cells: a microdialysis in vitro study

Autor: Maria Grazia Taras, Rossana Migheli, Maria Rosaria Delogu, Giovanni Esposito, Maria Pina Mura, Pier Andrea Serra, Gaia Giovanna Maria Rocchitta, Egidio Miele, Maddalena Miele, Maria Speranza Desole

Publikováno v: Journal of Neurochemistry. 86:1403-1413

In vitro microdialysis was used to investigate the mechanism of nitric oxide (NO) donor-induced changes in dopamine (DA) secretion from PC12 cells. Infusion of the NO-donor S-nitrosoN-acetylpenicillamine (SNAP, 1.0 mM) induced a long-lasting increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::047b8ebc8663598e76618ce92193b9e5
https://doi.org/10.1046/j.1471-4159.2003.01947.x

Zobrazit plný text záznamu

The Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induces Apoptosis in Mouse Nigrostriatal Glia

Autor: Maria Speranza Desole, L. Sciola, Maria Rosaria Delogu, Egidio Miele, Pier Andrea Serra, Rossana Migheli, Alessandra Spano, Gaia Giovanna Maria Rocchitta, Maddalena Miele, G Monaco

Publikováno v: Journal of Biological Chemistry. 277:34451-34461

Swiss mice were given 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 25 mg/kg/day, for 5 consecutive days and killed at different days after MPTP discontinuance. Decreases in striatal tyrosine hydroxylase activity and levels of dopamine and its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::384abaa87165fc02d486c60539e04175
https://doi.org/10.1074/jbc.m202099200

Zobrazit plný text záznamu

Enhancing Effect of Manganese on L-DOPA-Induced Apoptosis in PC12 Cells

Autor: Rossana Migheli, Chiara Godani, L. Sciola, Danilo Zangani, Pier Andrea Serra, Egidio Miele, Maria Speranza Desole, Maria Rosaria Delogu, Guglielmo De Natale

Publikováno v: Journal of Neurochemistry. 73:1155-1163

L-DOPA and manganese both induce oxidative stress-mediated apoptosis in catecholaminergic PC12 cells. In this study, exposure of PC12 cells to 0.2 m M MnCl 2 or 10-20 μ M L-DOPA neither affected cell viability, determined by the 3-(4,5-dimethylthiaz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db1e51904e6f99018ed7d51ea9a3eec
https://doi.org/10.1046/j.1471-4159.1999.0731155.x

Zobrazit plný text záznamu

Glutathione deficiency potentiates manganese-induced increases in compounds associated with high-energy phosphate degradation in discrete brain areas of young and aged rats

Autor: Rossana Migheli, Maria Rosaria Delogu, Giovanni Esposito, Maddalena Miele, Gaia Giovanna Maria Rocchitta, L. Fresu, Maria Speranza Desole, Pier Andrea Serra

Publikováno v: Aging Clinical and Experimental Research. 12:470-477

Aging is a factor known to increase neuronal vulnerability to oxidative stress, which is widely accepted as a mechanism of manganese-induced neuronal damage. We previously showed that subchronic exposure to manganese induced greater energy impairment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac4e0423bdcd7f8eadec1f28262cac4
https://doi.org/10.1007/bf03339879

Zobrazit plný text záznamu

Glutamate and catabolites of high-energy phosphates in the striatum and brainstem of young and aged rats subchronically exposed to manganese

Autor: Maria Rosaria Delogu, Maddalena Miele, Rossana Migheli, Maria Speranza Desole, Pier Andrea Serra, Giovanni Esposito, Gaia Giovanna Maria Rocchitta

Publikováno v: Scopus-Elsevier

The degradation of high-energy phosphates was recently shown to precede manganese-induced cellular death. We evaluated hypoxanthine, xanthine, uric acid and glutamate levels in the striatum and brainstem of 3- and 20-month-old rats after subchronic o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09c8d118c8af71d735481858ec1d497
https://doi.org/10.1007/bf03339866

Zobrazit plný text záznamu

Role of oxidative stress in the manganese and 1-methyl-4-(2′-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced apoptosis in PC12 cells

Autor: Maria Speranza Desole, S. Sircana, Maria Rosaria Delogu, Egidio Miele, L. Sciola, Rossana Migheli

Publikováno v: Neurochemistry International. 31:169-176

Oxidative stress is thought to play a key role in the apoptotic death of several cellular systems, including neurons. Oxidative stress is proposed also as a mechanism of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- and manganes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baae1906e6099369f60dbdee307135b3
https://doi.org/10.1016/s0197-0186(96)00146-5

Zobrazit plný text záznamu

Manganese and 1-methyl-4-(2′-ethylphenyl)-1,2,3,6-tetrahydropyridine induce apoptosis in PC12 cells

Autor: Maria Rosaria Delogu, L. Sciola, S. Sircana, Rossana Migheli, Maria Speranza Desole

Publikováno v: Neuroscience Letters. 209:193-196

Oxidative stress is thought to play a key role both in the neurotoxin MPTP- and manganese (Mn)-induced neurotoxicity and in apoptotic cell death. In the present study, we report that Mn and the MPTP analogue 1-methyl-4-(2′-ethylphenyl)-1,2,3,6-tetr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::177fb19c4b2f956a361dbbc5c6f413eb
https://doi.org/10.1016/0304-3940(96)12645-8

Zobrazit plný text záznamu

Protective effect of deferoxamine on sodium nitroprusside-induced apoptosis in PC12 cells

Autor: G. De Natale, L. Sciola, S. Sircana, Maria Rosaria Delogu, C Godani, G Piras, Egidio Miele, Maria Speranza Desole, Rossana Migheli

Publikováno v: Neuroscience letters. 247(1)

Reportedly, the generation of nitric oxide (NO) may lead to iron mobilization from ferritin disrupting intracellular iron homeostasis and increasing levels of reactive oxygen species. In the present study, we evaluated the role of endogenous iron in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cc59d968e37371544b339303bb4865
https://pubmed.ncbi.nlm.nih.gov/9637395

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání