Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Maria Rosaria Del Giudice"'
Publikováno v:
Med. Chem. Commun.. 3:357-361
The research into selective ligands of misfolded protein plaques in Alzheimer's disease and in transmissible spongiform encephalopathies led to compound 3, based on the Congo Red framework and bearing two trifluoromethoxy groups. Histochemical experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b955c813620209c2de52cb809e9c3f0
https://doi.org/10.1039/c2md00254j
https://doi.org/10.1039/c2md00254j
Autor:
Carlo Mustazza, Maria Sbraccia, Maria Rosaria Del Giudice, Anna Borioni, Giuditta Bastanzio, Isabella Sestili
Publikováno v:
European Journal of Medicinal Chemistry. 46:1207-1221
Bivalent ligands constituted by two identical pharmacophores structurally related to the Nociceptin Opioid Receptor (NOPr) antagonist JTC-801 were synthesized and their binding affinities for NOPr were evaluated. The novel ligands are formed by two m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0e2febc63fd534c0c702ce17fb745cb
https://doi.org/10.1016/j.ejmech.2011.01.040
https://doi.org/10.1016/j.ejmech.2011.01.040
Autor:
Andrea Rodomonte, Isabella Sestili, Maria Rosaria Del Giudice, Carlo Mustazza, Maria Sbraccia, Anna Borioni
Publikováno v:
Journal of Medicinal Chemistry. 51:1058-1062
Some synthesized 1,2-dihydrospiro[isoquinoline-4(3 H),4'-piperidin]-3-ones were evaluated as ligands for nociceptin receptor (NOP receptor). Their affinity was established by binding studies, and efficacy was investigated by GTP binding experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f29515e667d837303ba9ea4eeb2144b
https://doi.org/10.1021/jm7009606
https://doi.org/10.1021/jm7009606
Autor:
Maria Sbraccia, Maria Rosaria Del Giudice, Rosella Ferretti, Andrea Rodomonte, Anna Borioni, Carlo Mustazza, Isabella Sestili
Publikováno v:
Chemical and Pharmaceutical Bulletin. 54:611-622
Some spiro[piperidine-4,2′(1′H)-quinazolin]-4′(3′H)-ones 3 and spiro[piperidine-4,5′(6′H)-[1,2,4]triazolo[1,5-c]quinazolines] 4 were synthesized and evaluated as ligands of the nociceptin receptor. The examined compounds showed partial ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2047248705d5ec3721eb77d8ccdd85
https://doi.org/10.1248/cpb.54.611
https://doi.org/10.1248/cpb.54.611
Autor:
Franco Gatta, Francesco Amenta, Khosrow Tayebati, Anna Borioni, Maria Rosaria Del Giudice, Stefano Pieretti, Paolo Tucci, Carlo Mustazza
Publikováno v:
Archiv der Pharmazie. 336:143-154
A series of 1-methyl-5-(pyrazol-3- and -5-yl- and 1,2,4-triazol-3- and 5-yl)-1,2,3,6-tetrahydropyridine derivatives structurally related to arecoline were synthesized and evaluated on M 1 , M 2 , and M 3 muscarinic receptors using [ 3 H]pirenzepine a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9e9bf4ac82a0baa81e0725d1eb1889
https://doi.org/10.1002/ardp.200390013
https://doi.org/10.1002/ardp.200390013
Autor:
Annarita Meneguz, Franco Gatta, Maria Teresa Volpe, Rosella Ferretti, Maria Rosaria Del Giudice, Anna Borioni, Carlo Mustazza, Paola Lorenzini
Publikováno v:
European Journal of Medicinal Chemistry. 37:91-109
In order to develop new cholinesterase agents effective against Alzheimer's disease (AD) we synthesized some phenylcarbamates structurally related to Rivastigmine and evaluated their in vitro and in vivo biological activity. Among the compounds which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0869df78eda2fa8b018bc0242a24e7d
https://doi.org/10.1016/s0223-5234(01)01324-1
https://doi.org/10.1016/s0223-5234(01)01324-1
Publikováno v:
Journal of Heterocyclic Chemistry. 38:1119-1129
This paper describes the preparation of some pyrazolo[1,5-a]-, 1,2,4-triazolo[1,5-a]- and imidazo[1,2-a]-pyrimidines substituted on the pyrimidine moiety by a 4-[(N-acetyl-N-ethyl)amino]phenyl group. A new synthesis of related benzo[h]pyrazolo[1,5-a]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40d0022f85de232949a627955f31dc1b
https://doi.org/10.1002/jhet.5570380516
https://doi.org/10.1002/jhet.5570380516
Publikováno v:
Journal of Heterocyclic Chemistry. 37:799-810
This paper describes the synthesis of some bicyclic 2-(3-dimethylcarbamoyloxyphenyl) substituted azaderivatives, obtained from 1,4- and 1,5-diketones, which were cyclized with ammonium acetate, methylamine and by reductive amination. Corresponding 3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e13381eff61913fc413a804c18ea1285
https://doi.org/10.1002/jhet.5570370422
https://doi.org/10.1002/jhet.5570370422
Publikováno v:
Bioorganic Chemistry. 27:197-205
The kinetics of the reaction catalyzed by human erythrocyte Acetylcholinesterase (AChE) is studied in the presence of its inhibitor Tacrine (1,2,3,4-tetrahydro-9-acridinamine), and of two newly synthesized compounds, 6-metoxy-Tacrine and N -eptyl-Tac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8805ebce86387e31c708db89acba93cb
https://doi.org/10.1006/bioo.1998.1121
https://doi.org/10.1006/bioo.1998.1121
Publikováno v:
Journal of Heterocyclic Chemistry. 35:915-922
This paper describes the synthesis of some 5-amino-1,2,3,4-tetrahydrobenzo[b][1,7]naphthyridines and 2,3,4,4a,5,6-hexahydrobenzo[c][2,6] naphthyridines starting from anilines and 1-benzyl-4-ethoxycarbonylpiperidin-3-one. The compounds were prepared i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a0fc9bf6ccc3cbb29b43cba8e12fceb
https://doi.org/10.1002/jhet.5570350422
https://doi.org/10.1002/jhet.5570350422