Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Maria R. Dichiara"'
Autor:
Peter I. Teng, Thomas Quertermous, Keith Abe, László G. Kömüves, James N. Topper, Maria R. Dichiara
Publikováno v:
Physiological Genomics. 11:99-107
We have developed a system utilizing the murine Tie2 promoter/enhancer coupled with the "tetracycline-on" regulatory elements to create a model that allows regulated and selective expression of a beta-galactosidase (betaGal) reporter transgene in the
Autor:
Michael A. Gimbrone, Maria R. DiChiara, James N. Topper, Keith R. Anderson, Jonathan D. Brown
Publikováno v:
Journal of Biological Chemistry. 274:8797-8805
Smad proteins are essential components of the intracellular signaling pathways utilized by members of the transforming growth factor-beta (TGF-beta) superfamily of growth factors. Certain Smad proteins (e.g. Smad1, -2, and -3) can act as regulated tr
Autor:
Jonathan D. Brown, Maria R. DiChiara, James N. Topper, Amy J. Williams, Tucker Collins, Dean A. Falb, Michael A. Gimbrone
Publikováno v:
Proceedings of the National Academy of Sciences. 95:9506-9511
The transforming growth factor-beta (TGF-beta) superfamily of growth factors and cytokines has been implicated in a variety of physiological and developmental processes within the cardiovascular system. Smad proteins are a recently described family o
The Egr-1 promoter contains information for constitutive and inducible expression in transgenic mice
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 14(13)
Egr-1 is an immediate early gene that couples short-term changes in the extracellular milieu to long-term changes in gene expression. Under in vitro conditions, the Egr-1 gene is expressed in many cell types and is induced by a wide variety of extrac
Autor:
Michael A. Gimbrone, Mark A. Perrella, Jeanne Marie Kiely, Maria R. DiChiara, Mu-En Lee, James N. Topper
Publikováno v:
The Journal of Experimental Medicine
Transforming growth factor (TGF)-beta(1) is a pleiotropic cytokine/growth factor that is thought to play a critical role in the modulation of inflammatory events. We demonstrate that exogenous TGF-beta(1) can inhibit the expression of the proinflamma