Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Maria R. Conte"'
Autor:
Jennifer C. Coleman, Luke Tattersall, Val Yianni, Laura Knight, Hongqiang Yu, Sadie R. Hallett, Philip Johnson, Ana J. Caetano, Charlie Cosstick, Anne J. Ridley, Alison Gartland, Maria R. Conte, Agamemnon E. Grigoriadis
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109288- (2024)
Summary: RNA-binding proteins (RBPs) are emerging as important regulators of cancer pathogenesis. We reveal that the RBPs LARP4A and LARP4B are differentially overexpressed in osteosarcoma and osteosarcoma lung metastases, as well as in prostate canc
Externí odkaz:
https://doaj.org/article/e05b9197d6e846339a41025635e63f0c
Autor:
Eva Crosas-Molist, Vittoria Graziani, Oscar Maiques, Pahini Pandya, Joanne Monger, Remi Samain, Samantha L. George, Saba Malik, Jerrine Salise, Valle Morales, Adrien Le Guennec, R. Andrew Atkinson, Rosa M. Marti, Xavier Matias-Guiu, Guillaume Charras, Maria R. Conte, Alberto Elosegui-Artola, Mark Holt, Victoria Sanz-Moreno
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Cell migration is crucial for cancer dissemination. We find that AMP-activated protein kinase (AMPK) controls cell migration by acting as an adhesion sensing molecular hub. In 3-dimensional matrices, fast-migrating amoeboid cancer cells exer
Externí odkaz:
https://doaj.org/article/350286488c1e4475afc3dd506fdbc8ec
Autor:
Vittoria Graziani, Aida Rodriguez Garcia, Lourdes Sainero Alcolado, Adrien Le Guennec, Marie Arsenian Henriksson, Maria R. Conte
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Medulloblastoma (MB) is the most common malignant brain tumour in children. High-risk MB patients harbouring MYC amplification or overexpression exhibit a very poor prognosis. Aberrant activation of MYC markedly reprograms cell metabolism to
Externí odkaz:
https://doaj.org/article/cc236716093846ce878ffd2ec238d06c
Autor:
Rebecca L. Charles, Giancarlo Abis, Beatriz F. Fernandez, Sebastian Guttzeit, Roberto Buccafusca, Maria R. Conte, Philip Eaton
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102107- (2021)
Soluble epoxide hydrolase (sEH), an enzyme that broadly regulates the cardiovascular system, hydrolyses epoxyeicosatrienoic acids (EETs) to their corresponding dihydroxyeicosatrienoic acids (DHETs). We previously showed that endogenous lipid electrop
Externí odkaz:
https://doaj.org/article/6c4dfd7f8fb5403ba6f81bf411240c08
Autor:
Jenna Scotcher, Oleksandra Prysyazhna, Andrii Boguslavskyi, Kornel Kistamas, Natasha Hadgraft, Eva D. Martin, Jenny Worthington, Olena Rudyk, Pedro Rodriguez Cutillas, Friederike Cuello, Michael J. Shattock, Michael S. Marber, Maria R. Conte, Adam Greenstein, David J. Greensmith, Luigi Venetucci, John F. Timms, Philip Eaton
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The stroke volume of the heart increases in response to an increase in the blood volume filling the heart. Here the authors reveal that this coordinated process is mediated in part by oxidative activation of the protein kinase G Iα, which phosphoryl
Externí odkaz:
https://doaj.org/article/03ace94ba067478fa8463d2ab1ace41b
Autor:
Joseph Chi Fung Ng, Michael S. Marber, Geoff Kelly, Franca Fraternali, Gian Felice De Nicola, Charles J. Nichols, Annika Keshu, Maria R. Conte
Publikováno v:
Journal of Medicinal Chemistry. 63:7559-7568
Nowadays, it is possible to combine X-ray crystallography and fragment screening in a medium throughput fashion to chemically probe the surfaces used by proteins to interact and use the outcome of the screens to systematically design protein-protein
Publikováno v:
Abis, G, Pacheco-Gómez, R, Bui, T T T & Conte, M R 2019, ' Isothermal Titration Calorimetry Enables Rapid Characterization of Enzyme Kinetics and Inhibition for the Human Soluble Epoxide Hydrolase ', Analytical Chemistry, vol. 91, no. 23, pp. 14865-14872 . https://doi.org/10.1021/acs.analchem.9b01847
Analytical Chemistry
Analytical Chemistry
Isothermal titration calorimetry (ITC) is conventionally used to acquire thermodynamic data for biological interactions. In recent years, ITC has emerged as a powerful tool to characterize enzyme kinetics. In this study, we have adapted a single-inje
Autor:
Philip Eaton, Rebecca L. Charles, Maria R. Conte, Giancarlo Abis, Beatriz F. Fernandez, Roberto Buccafusca, Sebastian Guttzeit
Publikováno v:
Redox Biology
Redox Biology, Vol 46, Iss, Pp 102107-(2021)
Redox Biology, Vol 46, Iss, Pp 102107-(2021)
Soluble epoxide hydrolase (sEH), an enzyme that broadly regulates the cardiovascular system, hydrolyses epoxyeicosatrienoic acids (EETs) to their corresponding dihydroxyeicosatrienoic acids (DHETs). We previously showed that endogenous lipid electrop
Autor:
Qiongju Qiu, Giancarlo Abis, Florence Mattingly-Peck, Steven Lynham, Franca Fraternali, Maria R Conte
Publikováno v:
Journal of Molecular Biology. 434:167600
The human soluble epoxide hydrolase (hsEH) is a key regulator of epoxy fatty acid (EpFA) metabolism. Inhibition of sEH can maintain endogenous levels of beneficial EpFAs and reduce the levels of their corresponding diol products, thus ameliorating a
Autor:
Celso G. Litholdo, David Honys, Vinod Kumar, Said Hafidh, Marie-Christine Carpentier, Katarina Kulichova, Elodie Billey, Claire Picart, Eric Maréchal, Viviane Jean, Maria R. Conte, Cécile Bousquet-Antonelli, Isabel Cruz-Gallardo, Jean-Marc Deragon
Publikováno v:
The Plant cell
The Plant cell, American Society of Plant Biologists (ASPB), 2021, 33 (8), pp.2637-2661. ⟨10.1093/plcell/koab131⟩
Plant Cell
The Plant cell, American Society of Plant Biologists (ASPB), 2021, ⟨10.1093/plcell/koab131⟩
The Plant cell, 2021, 33 (8), pp.2637-2661. ⟨10.1093/plcell/koab131⟩
The Plant cell, American Society of Plant Biologists (ASPB), 2021, 33 (8), pp.2637-2661. ⟨10.1093/plcell/koab131⟩
Plant Cell
The Plant cell, American Society of Plant Biologists (ASPB), 2021, ⟨10.1093/plcell/koab131⟩
The Plant cell, 2021, 33 (8), pp.2637-2661. ⟨10.1093/plcell/koab131⟩
Increasing evidence suggests that posttranscriptional regulation is a key player in the transition between mature pollen and the progamic phase (from pollination to fertilization). Nonetheless, the actors in this messenger RNA (mRNA)-based gene expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::868590a98029889a2aadbd394e167b83
https://hal-univ-perp.archives-ouvertes.fr/hal-03275017v2/file/Billeyetal_acceptedMS-2021.pdf
https://hal-univ-perp.archives-ouvertes.fr/hal-03275017v2/file/Billeyetal_acceptedMS-2021.pdf