Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Maria Poptsova"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract A long-standing question concerns the role of Z-DNA in transcription. Here we use a deep learning approach DeepZ that predicts Z-flipons based on DNA sequence, structural properties of nucleotides and omics data. We examined Z-flipons that a
Externí odkaz:
https://doaj.org/article/91fe760cdc314d319f1dc2f2e6e921f2
Autor:
Alexander Kirdeev, Konstantin Burkin, Anton Vorobev, Elena Zbirovskaya, Galina Lifshits, Konstantin Nikolaev, Elena Zelenskaya, Maxim Donnikov, Lyudmila Kovalenko, Irina Urvantseva, Maria Poptsova
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
BackgroundThe development of prognostic models for the identification of high-risk myocardial infarction (MI) patients is a crucial step toward personalized medicine. Genetic factors are known to be associated with an increased risk of cardiovascular
Externí odkaz:
https://doaj.org/article/31e4c87dc8e14b938e9c89cff335c216
Publikováno v:
Frontiers in Big Data, Vol 6 (2023)
Due to advances in NGS technologies whole-genome maps of various functional genomic elements were generated for a dozen of species, however experiments are still expensive and are not available for many species of interest. Deep learning methods beca
Externí odkaz:
https://doaj.org/article/81d011e5fcbc48e9a7972c01433b928f
Autor:
Alan Herbert, Maria Poptsova
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
We present evidence suggesting that the severe acute respiratory syndrome (SARS) coronavirus non-structural protein 13 (Nsp13) modulates the Z-RNA dependent regulated cell death pathways . We show that Z-prone sequences [called flipons] exist in coro
Externí odkaz:
https://doaj.org/article/6b400328cf3a461985462b1f3c4d4353
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4884 (2023)
The classical view of gene regulation draws from prokaryotic models, where responses to environmental changes involve operons regulated by sequence-specific protein interactions with DNA, although it is now known that operons are also modulated by sm
Externí odkaz:
https://doaj.org/article/d83449c310684ec1aa1163003c3a137f
Autor:
Kseniia Cheloshkina, Maria Poptsova
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-17 (2019)
Abstract Background Chromosomal rearrangements are the typical phenomena in cancer genomes causing gene disruptions and fusions, corruption of regulatory elements, damage to chromosome integrity. Among the factors contributing to genomic instability
Externí odkaz:
https://doaj.org/article/abe76469e3f54e4eb37849905021798d
Autor:
Kseniia Cheloshkina, Maria Poptsova
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 3, p e1008749 (2021)
Understanding mechanisms of cancer breakpoint mutagenesis is a difficult task and predictive models of cancer breakpoint formation have to this time failed to achieve even moderate predictive power. Here we take advantage of a machine learning approa
Externí odkaz:
https://doaj.org/article/ee1806ac81e1483683582ac51fc496f8
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3079 (2022)
Z-DNA binding protein (ZBP1) very much represents the nuclear option. By initiating inflammatory cell death (ICD), ZBP1 activates host defenses to destroy infectious threats. ZBP1 is also able to induce noninflammatory regulated cell death via apopto
Externí odkaz:
https://doaj.org/article/35270d00fc4e4f92a74eecacd164989a
Autor:
Alan Herbert, Sergey Karapetyan, Maria Poptsova, Karen M. Vasquez, Quentin Vicens, Beat Vögeli
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7686 (2021)
It is now difficult to believe that a biological function for the left-handed Z-DNA and Z-RNA conformations was once controversial. The papers in this Special Issue, “Z-DNA and Z-RNA: from Physical Structure to Biological Function”, are based on
Externí odkaz:
https://doaj.org/article/2c8a3b23681b477e82ef6cf59fd8163e
Autor:
Samprit Banerjee, Derek Oldridge, Maria Poptsova, Wasay M Hussain, Dimple Chakravarty, Francesca Demichelis
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17539 (2011)
Structural variants which cause changes in copy numbers constitute an important component of genomic variability. They account for 0.7% of genomic differences in two individual genomes, of which copy number variants (CNVs) are the largest component.
Externí odkaz:
https://doaj.org/article/9d50c3eddbc94778846516e58c2380a4