Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery

Autor: Rajesh Kumar Soni, Takahiro Yamazaki, Harley Y. Tse, Karthik Ramesh, Marco Viganò, Tsai Wanxia Li, Lorenzo Galluzzi, Lawrence J. Stern, Austin M. Graves, Laura Santambrogio, Massimo Gadina, Maria Pia Negroni, Hei Jung Kim, Paul A. Roche, Sangeetha Thangaswamy, Kateryna Morozova, Lisa K. Denzin, Padma P. Nanaware, Cristina C. Clement

Publikováno v: Immunity

Summary Hyperglycemia and hyperlipidemia are often observed in individuals with type II diabetes (T2D) and related mouse models. One dysmetabolic biochemical consequence is the non-enzymatic reaction between sugars, lipids, and proteins, favoring pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7750923dc05a0784735bcd3572d57dd0
https://doi.org/10.1016/j.immuni.2021.02.019

The N-terminal region of photocleavable peptides that bind HLA-DR1 determines the kinetics of fragment release

Autor: Lawrence J. Stern, Maria Pia Negroni

Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0199704 (2018)

Major Histocompatibility Complex class II (MHC-II) molecules bind peptides and present them to receptors on CD4+ T cells as part of the immune system's surveillance of pathogens and malignancy. In the absence of peptide, MHC-II equilibrates between p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9bdf8238904042f2c778fe3333d4b3
https://pubmed.ncbi.nlm.nih.gov/29965980

Autoantibodies against muscarinic receptors in breast cancer. Its role in tumor angiogenesis

Autor: María Gabriela Lombardi, María Elena Sales, Maria Pia Negroni, Carlos Cresta Morgado, Laura Tatiana Pelegrina, Maria Ester Castro, Gabriel L. Fiszman, María Eugenia Azar

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e57572 (2013)
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The presence of autoantibodies in cancer has become relevant in recent years. We demonstrated that autoantibodies purified from the sera of breast cancer patients activate muscarinic acetylcholine receptors in tumor cells. Immunoglobulin G (IgG) from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1618fd842debbd59b13e637f6b191a0
http://www.ncbi.nlm.nih.gov/pubmed/23460876

Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange

Autor: Lawrence J. Stern, James E. Evans, Katherine A. Kellersberger, Zarixia Zavala-Ruiz, Maria Pia Negroni, Corrie A. Painter

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 108(48)

HLA-DM is required for efficient peptide exchange on class II MHC molecules, but its mechanism of action is controversial. We trapped an intermediate state of class II MHC HLA-DR1 by substitution of αF54, resulting in a protein with increased HLA-DM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37562a2ca26bf8dad446f401036b9e97
https://pubmed.ncbi.nlm.nih.gov/22084083