Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Maria Pia Cosma"'
Autor:
Aayush Kant, Zixian Guo, Vinayak Vinayak, Maria Victoria Neguembor, Wing Shun Li, Vasundhara Agrawal, Emily Pujadas, Luay Almassalha, Vadim Backman, Melike Lakadamyali, Maria Pia Cosma, Vivek B. Shenoy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract In interphase nuclei, chromatin forms dense domains of characteristic sizes, but the influence of transcription and histone modifications on domain size is not understood. We present a theoretical model exploring this relationship, consideri
Externí odkaz:
https://doaj.org/article/7ba9d1e5bc1d47f38d36e5b6b9d90cfc
Autor:
Paraskevi Athanasouli, Martina Balli, Anchel De Jaime-Soguero, Annekatrien Boel, Sofia Papanikolaou, Bernard K. van der Veer, Adrian Janiszewski, Tijs Vanhessche, Annick Francis, Youssef El Laithy, Antonio Lo Nigro, Francesco Aulicino, Kian Peng Koh, Vincent Pasque, Maria Pia Cosma, Catherine Verfaillie, An Zwijsen, Björn Heindryckx, Christoforos Nikolaou, Frederic Lluis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Signal transduction and gene expression regulation via downstream transcription factors shape the early mammalian embryo. Here the authors show that Wnt/TCF7L1 transcriptional repressive activity is required for primitive endoderm lineage formation.
Externí odkaz:
https://doaj.org/article/8c6090935fbd461d86225955994338e9
Autor:
Hayley Porter, Yang Li, Maria Victoria Neguembor, Manuel Beltran, Wazeer Varsally, Laura Martin, Manuel Tavares Cornejo, Dubravka Pezić, Amandeep Bhamra, Silvia Surinova, Richard G Jenner, Maria Pia Cosma, Suzana Hadjur
Publikováno v:
eLife, Vol 12 (2023)
Most studies of cohesin function consider the Stromalin Antigen (STAG/SA) proteins as core complex members given their ubiquitous interaction with the cohesin ring. Here, we provide functional data to support the notion that the SA subunit is not a m
Externí odkaz:
https://doaj.org/article/c75b957f25434498af13a92ce3fcf355
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
One of the biggest paradoxes in biology is that human genome is roughly 2 m long, while the nucleus containing it is almost one million times smaller. To fit into the nucleus, DNA twists, bends and folds into several hierarchical levels of compaction
Externí odkaz:
https://doaj.org/article/a9d5e84386a546a09bd0f96bd3d3c70e
Autor:
Sergi Àngel Bonilla-Pons, Shoma Nakagawa, Elena Garreta Bahima, Álvaro Fernández-Blanco, Martina Pesaresi, Justin Christopher D'Antin, Ruben Sebastian-Perez, Daniela Greco, Eduardo Domínguez-Sala, Raúl Gómez-Riera, Rafael Ignacio Barraquer Compte, Mara Dierssen, Nuria Montserrat Pulido, Maria Pia Cosma
Publikováno v:
EBioMedicine, Vol 77, Iss , Pp 103914- (2022)
Summary: Background: Visual impairments are a critical medical hurdle to be addressed in modern society. Müller glia (MG) have regenerative potential in the retina in lower vertebrates, but not in mammals. However, in mice, in vivo cell fusion betwe
Externí odkaz:
https://doaj.org/article/692501e2ead24e82992f76b07a5e381f
Autor:
Laura Martin, Chiara Vicario, Álvaro Castells-García, Melike Lakadamyali, Maria Victoria Neguembor, Maria Pia Cosma
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100865- (2021)
Summary: Here, we describe three complementary microscopy-based approaches to quantify morphological changes of chromatin organization in cultured adherent cells: the analysis of the coefficient of variation of DNA, the measurement of DNA-free nuclea
Externí odkaz:
https://doaj.org/article/7bbec3d536b449d0b253eea70aae2097
Autor:
Elisa Pedone, Lorena Postiglione, Francesco Aulicino, Dan L. Rocca, Sandra Montes-Olivas, Mahmoud Khazim, Diego di Bernardo, Maria Pia Cosma, Lucia Marucci
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Cellular systems have numerous mechanisms to control gene expression. Here the authors build a Tet-On system with conditional destablising elements to regulate gene expression and protein stability, allowing fine modulation of mESC signalling pathway
Externí odkaz:
https://doaj.org/article/e79a3cc6f3294f59896d1257115ecf15
Autor:
Pablo Aurelio Gómez-García, Stephanie Portillo-Ledesma, Maria Victoria Neguembor, Martina Pesaresi, Walaa Oweis, Talia Rohrlich, Stefan Wieser, Eran Meshorer, Tamar Schlick, Maria Pia Cosma, Melike Lakadamyali
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108614- (2021)
Summary: Nucleosomes form heterogeneous groups in vivo, named clutches. Clutches are smaller and less dense in mouse embryonic stem cells (ESCs) compared to neural progenitor cells (NPCs). Using coarse-grained modeling of the pluripotency Pou5f1 gene
Externí odkaz:
https://doaj.org/article/09cbd6461b6b46cfb1f26dba19f5e8a8
Autor:
Martina Pesaresi, Sergi A. Bonilla-Pons, Giacoma Simonte, Daniela Sanges, Umberto Di Vicino, Maria Pia Cosma
Publikováno v:
EBioMedicine, Vol 30, Iss , Pp 38-51 (2018)
Müller glial cells (MGCs) represent the most plastic cell type found in the retina. Following injury, zebrafish and avian MGCs can efficiently re-enter the cell cycle, proliferate and generate new functional neurons. The regenerative potential of ma
Externí odkaz:
https://doaj.org/article/17042aea87d6478685eddb38d1d86421
Autor:
Wassim Altarche-Xifro, Umberto di Vicino, Maria Isabel Muñoz-Martin, Analía Bortolozzi, Jordi Bové, Miquel Vila, Maria Pia Cosma
Publikováno v:
EBioMedicine, Vol 8, Iss C, Pp 83-95 (2016)
Parkinson's disease is a common neurodegenerative disorder, which is due to the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and for which no definitive cure is currently available. Cellular functions in mouse and human t
Externí odkaz:
https://doaj.org/article/c0e012080bd1457eb636cddbb80db9c4