Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Maria Petropavlovskaia"'
Autor:
Maria Petropavlovskaia, Beatrice Assouline-Thomas, Jessica Cuerquis, Jing Zhao, Shaun Violette-Deslauriers, Eni Nano, Nicoletta Eliopoulos, Lawrence Rosenberg
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35372- (2024)
Mesenchymal stem/stromal cells (MSCs) are emerging as a new therapy for diabetes. Here we investigate the properties of MSCs engineered to express Islet Neogenesis Associated Protein (INGAP) previously shown to reverse diabetes in animal models and e
Externí odkaz:
https://doaj.org/article/f41f8cdf79f647ae8031aed30ac59381
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract The goal of this study was to determine whether recombinant Islet NeoGenesis Associated Protein (rINGAP) and its active core, a pentadecapeptide INGAP104–118 (Ingap-p), protect β cells against cytokine-induced death. INGAP has been shown
Externí odkaz:
https://doaj.org/article/281662e6fc8b49fdb6d7c1dcb29d78c3
Autor:
Jason Michael Patapas, Dusica Maysinger, Maria Petropavlovskaia, Jeff Ji, Armen Khatchadourian, Julia Makhlin, Lawrence Rosenberg
Publikováno v:
Journal of Cellular and Molecular Medicine
Both type 2 diabetes (T2D) and obesity are characterized by excessive hyperlipidaemia and subsequent lipid droplet (LD) accumulation in adipose tissue. To investigate whether LDs also accumulate in β‐cells of T2D patients, we assessed the expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45756fbea452deb28f075eef17908fd
http://europepmc.org/articles/PMC6433726
http://europepmc.org/articles/PMC6433726
Autor:
Béatrice Assouline-Thomas, Maria Petropavlovskaia, Jonathan Zhu, Lawrence Rosenberg, Julia Makhlin, Jieping Ding, Jamal Daoud, Mandana Moosavi
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 303:E917-E927
Islet neogenesis-associated protein (INGAP) was discovered in the partially duct-obstructed hamster pancreas as a factor inducing formation of new duct-associated islets. A bioactive portion of INGAP, INGAP104–118peptide (INGAP-P), has been shown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c875b66197d019521f63a48462e382f1
https://doi.org/10.1152/ajpendo.00670.2011
https://doi.org/10.1152/ajpendo.00670.2011
Autor:
Robert DiRaddo, Maria Petropavlovskaia, Jamal Daoud, Maryam Tabrizian, Jason Michael Patapas, Christian Degrandpre, Lawrence Rosenberg
Publikováno v:
Biomaterials. 32:1536-1542
Human pancreatic islet in vitro culture is very challenging and requires the presence of various extra cellular matrix (ECM) components in a three-dimensional environment, which provides mechanical and biological support. The development of such an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b78d865a81f6069da93de7707b5838
https://doi.org/10.1016/j.biomaterials.2010.10.036
https://doi.org/10.1016/j.biomaterials.2010.10.036
Publikováno v:
Biomaterials. 31:1676-1682
Human islet isolation leads to the loss of the ECM basement membrane which contributes to eventual apoptosis in vitro. The reestablishment of this environment is vital in understanding the mechanism of islet interaction with its surroundings in order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bdf39a61eb52d439148b89f1df6c760
https://doi.org/10.1016/j.biomaterials.2009.11.057
https://doi.org/10.1016/j.biomaterials.2009.11.057
Autor:
Béatrice Assouline-Thomas, David V. McLeod, Julia Makhlin, Jieping Ding, Maria Petropavlovskaia, Amélie Pilotte, Stephen C. Hanley, Bernard Massie, Lawrence Rosenberg
Publikováno v:
Protein Expression and Purification. 69:1-8
Islet Neogenesis Associated Protein (INGAP) is implicated in pancreatic islet neogenesis. INGAP peptide, a pentadecapeptide comprising amino acids 104–118, reverses diabetes in rodents and improves glucose homeostasis in patients with diabetes. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5807b7bfa1cb886189e8d287a6e587a3
https://doi.org/10.1016/j.pep.2009.07.009
https://doi.org/10.1016/j.pep.2009.07.009
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1769:579-585
The regenerating (Reg) genes are associated with tissue repair and have been directly implicated in pancreatic beta-cell regeneration. A hamster Reg3, Islet neogenesis associated protein (INGAP), has been shown to possess anti-diabetic properties in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed38d8c1c972c559d8ee73197fcd8d6
https://doi.org/10.1016/j.bbaexp.2007.06.002
https://doi.org/10.1016/j.bbaexp.2007.06.002
Autor:
Lawrence Rosenberg, Maria Petropavlovskaia, Daniel Ellis, Julia Makhlin, Jieping Ding, Béatrice Assouline-Thomas
Publikováno v:
Differentiation; research in biological diversity. 90(4-5)
Regeneration of β-cells in diabetic patients is an important goal of diabetes research. Islet Neogenesis Associated Protein (INGAP) was discovered in the partially duct-obstructed hamster pancreas. Its bioactive fragment, pentadecapeptide 104-118 (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4012d08de824c79bbfdc2023e4e39b95
https://pubmed.ncbi.nlm.nih.gov/26558987
https://pubmed.ncbi.nlm.nih.gov/26558987
Characterization of human islet-like structures generated from pancreatic precursor cells in culture
Autor:
Leo A. Behie, Michael S. Kallos, Maria Petropavlovskaia, Arindom Sen, Lawrence Rosenberg, Cheryl A. Bodnar
Publikováno v:
Biotechnology and Bioengineering. 93:980-988
This study addresses the characterization of human islet-like structures generated from a newly discovered sparse population of precursor cells (Petropavlovskaia and Rosenberg, 2002) in the human pancreas. These cells may be progenitor cells capable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc438f0711b806d14a1d0d0b85cf4de4
https://doi.org/10.1002/bit.20801
https://doi.org/10.1002/bit.20801