Identification of Key Small Non‐Coding MicroRNAs Controlling Pacemaker Mechanisms in the Human Sinus Node

Autor: Maria Petkova, Andrew J. Atkinson, Joseph Yanni, Luke Stuart, Abimbola J. Aminu, Alexandra D. Ivanova, Ksenia B. Pustovit, Connor Geragthy, Amy Feather, Ning Li, Yu Zhang, Delvac Oceandy, Filip Perde, Peter Molenaar, Alicia D’Souza, Vadim V. Fedorov, Halina Dobrzynski

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 20 (2020)

Background The sinus node (SN) is the primary pacemaker of the heart. SN myocytes possess distinctive action potential morphology with spontaneous diastolic depolarization because of a unique expression of ion channels and Ca2+‐handling proteins. M

Externí odkaz: https://doaj.org/article/375542e1a34747dcbe6c389f36654b67

Humor competence in English as a second or foreign language

Autor: Maria Petkova

Publikováno v: Zbornik radova Pedagoskog fakulteta Uzice. :91-102

Developing humor competence in a second or foreign language is difficult, but it is very important for successful intercultural communication. The nature of humor and its sociocultural functions make humor competence one of the last hurdles even adva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ffcce2ade910f0f5204c474f9a2e2bc
https://doi.org/10.5937/zrpfu2123091p

Further insights into the molecular complexity of the human sinus node - The role of 'novel' transcription factors and microRNAs

Autor: Vladislav S. Kuzmin, Weixuan Chen, Filip Virgil Perde, Mateusz K. Hołda, Halina Dobrzynski, Abimbola J. Aminu, Marcin Kuniewicz, Peter C. M. Molenaar, Andrew Atkinson, Robert T. Simms, Maria Petkova, Joseph Yanni, Zeyuan Yin, Alex D. Morris

Publikováno v: Aminu, A J, Petkova, M, Atkinson, A J, Yanni, J, Morris, A D, Simms, R T, Chen, W, Yin, Z, Kuniewicz, M, Holda, M K, Kuzmin, V S, Perde, F, Molenaar, P & Dobrzynski, H 2021, ' Further insights into the molecular complexity of the human sinus node-The role of 'novel' transcription factors and microRNAs ', Progress in biophysics and molecular biology, vol. 166, pp. 86-104 . https://doi.org/10.1016/j.pbiomolbio.2021.04.008

RESEARCH PURPOSE: The sinus node (SN) is the heart's primary pacemaker. Key ion channels (mainly the funny channel, HCN4) and Ca2+-handling proteins in the SN are responsible for its function. Transcription factors (TFs) regulate gene expression thro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7700c0b2042feec85a0e70f3fae4ba89
https://doi.org/10.1016/j.pbiomolbio.2021.04.008

Micro-RNA 133a-3p induces repolarization abnormalities in atrial myocardium and modulates ventricular electrophysiology affecting I

Autor: Vladislav S, Kuzmin, Alexandra D, Ivanova, Tatiana S, Filatova, Ksenia B, Pustovit, Anastasia A, Kobylina, Andrew J, Atkinson, Maria, Petkova, Yurij I, Voronkov, Denis V, Abramochkin, Halina, Dobrzynski

Publikováno v: European journal of pharmacology. 908

Mir-133a-3p is the most abundant myocardial microRNA. The impact of mir-133a-3p on cardiac electrophysiology is poorly explored. In this study, we investigated the effects of mir-133a-3p on the main ionic currents critical for action potential (AP) g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b534038ced5dacd154671b2260651d7
https://pubmed.ncbi.nlm.nih.gov/34310913

Silencing miR-370-3p rescues funny current and sinus node function in heart failure

Autor: Xue Cai, Yanwen Wang, Andrew Atkinson, Stanislav O. Zakharkin, Mark R. Boyett, Jonathan Ariyaratnam, Elizabeth J. Cartwright, Maria Petkova, Christina Hayward, Bryan A. Whitson, Vadim V. Fedorov, Ursula Doris, Min Zi, Peter J. Mohler, Sam Griffiths-Jones, Sunil Jit R. J. Logantha, George Hart, Paul M.L. Janssen, Joseph Yanni, Moinuddin Choudhury, Matthew Smith, Shu Nakao, Delvac Oceandy, Halina Dobrzynski, Leo A. H. Zeef, Alicia D'Souza, Ning Li, Brian J. Hansen

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-23 (2020)
Yanni Gerges, J, D'Souza, A, Wang, Y, Li, N, Hansen, B J, Zakharkin, S, Smith, M, Hayward, C, Whitson, B A, Mohler, P J, Janssen, P M L, Zeef, L, Choudhury, M, Zi, M, Cai, X, Logantha, S, Nakao, S, Atkinson, A, Petkova, M, Doris, U, Ariyaratnam, J, Cartwright, E, Griffiths-Jones, S, Hart, G, Federov, V V, Oceandy, D, Dobrzynski, H & Boyett, M 2020, ' Silencing miR-370-3p rescues funny current and sinus node function in heart failure ', Scientific Reports, vol. 10, 11279 . https://doi.org/10.1038/s41598-020-67790-0
Yanni, J, D’Souza, A, Wang, Y, Li, N, Hansen, B J, Zakharkin, S O, Smith, M, Hayward, C, Whitson, B A, Mohler, P J, Janssen, P M L, Zeef, L, Choudhury, M, Zi, M, Cai, X, Logantha, S J R J, Nakao, S, Atkinson, A, Petkova, M, Doris, U, Ariyaratnam, J, Cartwright, E J, Griffiths-Jones, S, Hart, G, Fedorov, V V, Oceandy, D, Dobrzynski, H & Boyett, M R 2020, ' Silencing miR-370-3p rescues funny current and sinus node function in heart failure ', Scientific Reports, vol. 10, no. 1, 11279 . https://doi.org/10.1038/s41598-020-67790-0

Bradyarrhythmias are an important cause of mortality in heart failure and previous studies indicate a mechanistic role for electrical remodelling of the key pacemaking ion channel HCN4 in this process. Here we show that, in a mouse model of heart fai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e59220189529d7be2817a2984aa0ff
http://europepmc.org/articles/PMC7347645