Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Maria Penzo"'
Autor:
Maria Penzo, Laura de las Heras-Dueña, Lydia Mata-Cantero, Beatriz Diaz-Hernandez, Maria-Jesus Vazquez-Muñiz, Sonja Ghidelli-Disse, Gerard Drewes, Elena Fernandez-Alvaro, David A. Baker
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract Antimalarial drug resistance compels the quest for new compounds that target alternative pathways to current drugs. The Plasmodium cyclic GMP-dependent protein kinase (PKG) has essential functions in all of the major life cycle developmental
Externí odkaz:
https://doaj.org/article/7b1853796974419994e20d37569169f5
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
The single-celled apicomplexan parasite Plasmodium falciparum is responsible for the majority of deaths due to malaria each year. The selection of drug resistance has been a recurring theme over the decades with each new drug that is developed. It is
Externí odkaz:
https://doaj.org/article/fcb48191b33046e2ac5c9b69cacafb3d
Autor:
David A. Baker, Laura G. Drought, Christian Flueck, Stephanie D. Nofal, Avnish Patel, Maria Penzo, Eloise M. Walker
Publikováno v:
Open Biology, Vol 7, Iss 12 (2017)
The cyclic nucleotides 3′, 5′-cyclic adenosine monophosphate (cAMP) and 3′, 5′-cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most animal cell types. They usually mediate an extracellular stimulus to drive a chang
Externí odkaz:
https://doaj.org/article/18f7548d2de1411f809790675d5bf748
Autor:
Christine R Collins, Fiona Hackett, Malcolm Strath, Maria Penzo, Chrislaine Withers-Martinez, David A Baker, Michael J Blackman
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003344 (2013)
The malaria parasite replicates within an intraerythrocytic parasitophorous vacuole (PV). Eventually, in a tightly regulated process called egress, proteins of the PV and intracellular merozoite surface are modified by an essential parasite serine pr
Externí odkaz:
https://doaj.org/article/0ac5d59a497342cd85a38a3530f38e38
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Frontiers in Microbiology
Frontiers in Microbiology
The single-celled apicomplexan parasite Plasmodium falciparum is responsible for the majority of deaths due to malaria each year. The selection of drug resistance has been a recurring theme over the decades with each new drug that is developed. It is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37cbc6adf11367c13d09d68d2de5d3af
https://www.frontiersin.org/articles/10.3389/fmicb.2020.602803/full
https://www.frontiersin.org/articles/10.3389/fmicb.2020.602803/full
Autor:
Aigars Jirgensons, Michael J. Blackman, Simone Fulle, Paul W. Finn, Maria Penzo, Samir Satish Kher, Jean-Paul Ebejer
Publikováno v:
Chemistry of Heterocyclic Compounds. 50:1457-1463
2,3-Bis(phenylamino)quinoxalines have been identified as a novel class of malarial protease PfSUB1 inhibitors by screening of Malaria Box compounds. The synthesis of analog series and investigation of their inhibitory activity provided preliminary st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::881449c8d2fdacbe79de4675c16d1b75
https://doi.org/10.1007/s10593-014-1610-4
https://doi.org/10.1007/s10593-014-1610-4
Autor:
Laura Drought, Maria Penzo, Stephanie D. Nofal, David A. Baker, Eloise M. Walker, Avnish Patel, Christian Flueck
Publikováno v:
Open Biology
Open Biology, Vol 7, Iss 12 (2017)
Open Biology, Vol 7, Iss 12 (2017)
The cyclic nucleotides 3′, 5′-cyclic adenosine monophosphate (cAMP) and 3′, 5′-cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most animal cell types. They usually mediate an extracellular stimulus to drive a chang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816bfa4dc68210aba9407843b8dc1456
https://pubmed.ncbi.nlm.nih.gov/29263246
https://pubmed.ncbi.nlm.nih.gov/29263246
Autor:
Simone Fulle, Michael J. Blackman, Aigars Jirgensons, Maria Penzo, Samir Satish Kher, Paul W. Finn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4486-4489
Peptidic α-ketoamides have been developed as inhibitors of the malarial protease PfSUB1. The design of inhibitors was based on the best known endogenous PfSUB1 substrate sequence, leading to compounds with low micromolar to submicromolar inhibitory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60dadf63991592c7852a2e5eff114a67
https://doi.org/10.1016/j.bmcl.2014.07.086
https://doi.org/10.1016/j.bmcl.2014.07.086
Autor:
Sandra Gemma, Giuseppe Campiani, Ettore Novellino, Margherita Brindisi, Simone Brogi, Maria Penzo, Luisa Savini, Simone Giovani, Stefania Butini, Michael J. Blackman
The etiological agent of the most dangerous form of malaria, Plasmodium falciparum, has developed resistance or reduced sensitivity to the majority of the drugs available to treat this deadly disease. Innovative antimalarial therapies are therefore u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48aea7cc841da548f81b80c7011f070
http://hdl.handle.net/11588/586191
http://hdl.handle.net/11588/586191
Autor:
Kostas Koussis, Simone Fulle, Michael J. Blackman, Aigars Jirgensons, Maria Penzo, Paul W. Finn, Catherine Suarez, Samir Satish Kher, Chrislaine Withers-Martinez, Jean-Paul Ebejer, Fiona Hackett
Publikováno v:
International Journal for Parasitology
Release of the malaria merozoite from its host erythrocyte (egress) and invasion of a fresh cell are crucial steps in the life cycle of the malaria pathogen. Subtilisin-like protease 1 (SUB1) is a parasite serine protease implicated in both processes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4b89688e92c996dc932d0b59a82762
http://www.sciencedirect.com/science/article/pii/S0020751912000859
http://www.sciencedirect.com/science/article/pii/S0020751912000859