Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Maria Paz Ocaranza"'
Autor:
Maria Paz Ocaranza, Patricio Valderas, Jackeline Moya, Luigi Gabrielli, Iván Godoy, Samuel Córdova, Paul Mac Nab, Lorena García, Luis Farías, Jorge E. Jalil
Publikováno v:
Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-12 (2020)
Abstract Background The intracellular ROCK signaling pathway is an important modulator of blood pressure and of cardiovascular and renal remodeling when Rho-kinase activity is increased. Besides, in preclinical models of diabetes, ROCK activation has
Externí odkaz:
https://doaj.org/article/4e2bcc6c0810436993c1b1ce3b0fda7c
Autor:
Maria Paz Ocaranza, Jorge E. Jalil, Rodrigo Altamirano, Ana de León, Jackeline Moya, Alejandra Lonis, Luigi Gabrielli, Paul Mac Nab, Samuel Córdova, Alejandro Paredes, Ismael Vergara, Alex Bittner, Karime Sabat, Karla Pastorini
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Reverse remodeling is a clinically relevant endpoint in heart failure with reduced ejection fraction (HFrEF). Rho-kinase (ROCK) signaling cascade activation correlates with cardiac remodeling and left ventricular (LV) systolic dysfunction
Externí odkaz:
https://doaj.org/article/6be449dced514ba88094fb492a1bc5b8
Autor:
Evelyn, Mendoza-Torres, Jaime A, Riquelme, Alejandra, Vielma, Andrea Ramirez, Sagredo, Luigi, Gabrielli, Roberto, Bravo-Sagua, Jorge E, Jalil, Beverly A, Rothermel, Gina, Sanchez, Maria Paz, Ocaranza, Sergio, Lavandero
Publikováno v:
Pharmacological research. 135
Angiotensin-(19), a peptide of the non-classical renin angiotensin system, has been shown to prevent and revert hypertension and cardiac hypertrophy. We hypothetized that systemic delivery of angiotensin-(1-9) following myocardial infarction will als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f6d3dc88074b34be21e333e4b83abe86
https://pubmed.ncbi.nlm.nih.gov/30048754
https://pubmed.ncbi.nlm.nih.gov/30048754
Autor:
Jorge E. Jalil, Luigi Gabrielli, María Paz Ocaranza, Paul MacNab, Rodrigo Fernández, Bruno Grassi, Paulina Jofré, Hugo Verdejo, Monica Acevedo, Samuel Cordova, Luis Sanhueza, Douglas Greig
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4407 (2024)
This review examines the impact of obesity on the pathophysiology of heart failure with preserved ejection fraction (HFpEF) and focuses on novel mechanisms for HFpEF prevention using a glucagon-like peptide-1 receptor agonism (GLP-1 RA). Obesity can
Externí odkaz:
https://doaj.org/article/efe8ad8cc25f49fc8cefdf023d601dfd
Autor:
Maria Paz Ocaranza, Bélgica Villegas, Jackeline Moya, Victor Barrientos, Ulises Novoa, Olga Pérez, Stefan Walkowiak, Mario Chiong, Sergio Lavandero, Luis Michea, Jorge Jalil
Publikováno v:
Hypertension. 62
Previously, we found in experimental hypertension (DOCA salt model), that the RhoA/Rho-kinase pathway inhibition by fasudil decreases hypertension (HT), angiotensin (Ang) II levels and vascular remodeling. Besides, in this model fasudil increased ACE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c551631368733cefaafbc9afdd936ceb
https://doi.org/10.1161/hyp.62.suppl_1.a44
https://doi.org/10.1161/hyp.62.suppl_1.a44
Autor:
Felipe Contreras-Briceño, Sebastián Herrera, Julian Vega-Adauy, Manuel Salinas, María Paz Ocaranza, Jorge E. Jalil, Jorge Mandiola, Lorena García, Mario Chiong, Pablo F. Castro, Sergio Lavandero, Luigi Gabrielli
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Introduction: An increased risk of atrial fibrillation (AF) has been demonstrated in high-performance athletes. Soluble vascular adhesion molecule-1 (sVCAM-1), a biomarker involved in inflammation and cardiac remodeling, is associated with the develo
Externí odkaz:
https://doaj.org/article/a7f77ab658454e38a792bc7f5c527b4c
Autor:
Paulina Villar-Fincheira, Aaron J. Paredes, Tomás Hernández-Díaz, Ignacio Norambuena-Soto, Nicole Cancino-Arenas, Fernanda Sanhueza-Olivares, Felipe Contreras-Briceño, Jorge Mandiola, Nicole Bruneau, Lorena García, María Paz Ocaranza, Rodrigo Troncoso, Luigi Gabrielli, Mario Chiong
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Little is known about the effects of training load on exercise-induced plasma increase of interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) and their relationship with vascular remodeling. We sought to evaluate the role of sIL 6R as a regulator
Externí odkaz:
https://doaj.org/article/30591f36357147439c19e17f73b57cff
Autor:
Carolina Fernández, Natalia Torrealba, Francisco Altamirano, Valeria Garrido-Moreno, César Vásquez-Trincado, Raúl Flores-Vergara, Camila López-Crisosto, María Paz Ocaranza, Mario Chiong, Zully Pedrozo, Sergio Lavandero
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0255452 (2021)
Cardiac hypertrophy is the result of responses to various physiological or pathological stimuli. Recently, we showed that polycystin-1 participates in cardiomyocyte hypertrophy elicited by pressure overload and mechanical stress. Interestingly, polyc
Externí odkaz:
https://doaj.org/article/282852eddbe64e25877af76197d62e17
Autor:
Felipe Contreras-Briceño, Julián Vega, Jorge Mandiola, María Paz Ocaranza, Sebastián Herrera, Manuel Salinas, Rodrigo Fernández, Jorge E. Jalil, Sergio Lavandero, Mario Chiong, Paz Godoy, Pablo F. Castro, Marta Sitges, Luigi Gabrielli
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 10, p 118 (2021)
This single-blind and cross-sectional study evaluated the role of Rho-kinase (ROCK) as a biomarker of the cardiovascular remodelling process assessed by echocardiography in competitive long-distance runners (LDRs) during the training period before a
Externí odkaz:
https://doaj.org/article/5ee13dd1905e454b8bc51ad28be736e3
Autor:
Sabrina Sepúlveda-Rivas, Matías S. Leal, Zully Pedrozo, Marcelo J. Kogan, María Paz Ocaranza, Javier O. Morales
Publikováno v:
Pharmaceutics, Vol 13, Iss 6, p 822 (2021)
Ang-(1-9) peptide is a bioactive vasodilator peptide that prevents cardiomyocyte hypertrophy in vitro and in vivo as well as lowers blood pressure and pathological cardiovascular remodeling; however, it has a reduced half-life in circulation, requiri
Externí odkaz:
https://doaj.org/article/4d48c4ba122d4e159234a8b26ac613d3