Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Maria Paximadis"'
Autor:
Joy Ebonwu, Ria Lassaunière, Maria Paximadis, Renate Strehlau, Glenda E Gray, Louise Kuhn, Caroline T Tiemessen
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0273933 (2022)
BackgroundSome mother-to-child transmission (MTCT) studies suggest that allelic variations of Fc gamma receptors (FcγR) play a role in infant HIV-1 acquisition, but findings are inconsistent. To address the limitations of previous studies, the prese
Externí odkaz:
https://doaj.org/article/8b85b10822cb4583859595feab5079b6
Autor:
Anabela C. P. Picton, Maria Paximadis, Gemma W. Koor, Avani Bharuthram, Sharon Shalekoff, Ria Lassauniere, Prudence Ive, Caroline T. Tiemessen
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Unique Individuals who exhibit either suppressive HIV-1 control, or the ability to maintain low viral load set-points and preserve their CD4+ T cell counts for extended time periods in the absence of antiretroviral therapy, are broadly termed HIV-1 c
Externí odkaz:
https://doaj.org/article/c32ed9fa4b35498eb88ff0efff3ecc7b
Autor:
Joy Ebonwu, Ria Lassaunière, Maria Paximadis, Mark Goosen, Renate Strehlau, Glenda E. Gray, Louise Kuhn, Caroline T. Tiemessen
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In the Thai RV144 HIV-1 vaccine trial, a three-variant haplotype within the Fc gamma receptor 2C gene (FCGR2C) reduced the risk of HIV-1 acquisition. A follow-on trial, HVTN702, of a similar vaccine candidate found no efficacy in South Africa, where
Externí odkaz:
https://doaj.org/article/606f17dc663147008740c3e9a01e0b5c
Autor:
Avy Violari, Mark F. Cotton, Louise Kuhn, Diana B. Schramm, Maria Paximadis, Shayne Loubser, Sharon Shalekoff, Bianca Da Costa Dias, Kennedy Otwombe, Afaaf Liberty, James McIntyre, Abdel Babiker, Diana Gibb, Caroline T. Tiemessen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Some perinatally HIV infected children who have received early antiretroviral therapy (ART) show long-term sustained virological control after ART cessation. Here the authors describe a case who, at age 9.5 years, shows normal CD4:CD8 T cell ratios a
Externí odkaz:
https://doaj.org/article/0442ca91087b4ff58b5ff26e9317a03a
Autor:
Louise Kuhn, Maria Paximadis, Bianca Da Costa Dias, Shayne Loubser, Renate Strehlau, Faeezah Patel, Stephanie Shiau, Ashraf Coovadia, Elaine J Abrams, Caroline T Tiemessen
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195514 (2018)
BackgroundThe latent viral reservoir is the major obstacle to achieving HIV remission and necessitates life-long antiretroviral therapy (ART) for HIV-infected individuals. Studies in adults and children have found that initiating ART soon after infec
Externí odkaz:
https://doaj.org/article/1db6f53e69af469eb0f547b9b51bc46f
Autor:
Lindy L. Esterhuizen, Darren Martin, Gerhard Pietersen, Edward P. Rybicki, Natasha Abraham, Kenneth G. Mabasa, Shaun Berry, Nurbibi Cossa, Valter N. Nuaila, Marie E. C. Rey, Maria Paximadis, Joseph Ndunguru, Leigh C. Berrie
Publikováno v:
Viruses, Vol 4, Iss 9, Pp 1753-1791 (2012)
The family Geminiviridae comprises a group of plant-infecting circular ssDNA viruses that severely constrain agricultural production throughout the temperate regions of the world, and are a particularly serious threat to food security in sub-Saharan
Externí odkaz:
https://doaj.org/article/154c942c01cc4ae4a438dbb5366b8db5
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67780 (2013)
An insertion-deletion (indel) polymorphism within the 3' untranslated region (UTR) of HLA-C has been shown to be involved in the regulation of HLA-C expression. Individuals who carry a deletion at this position exhibit increased HLA-C expression, whi
Externí odkaz:
https://doaj.org/article/4f8e4ab934a24b7889adbd353a544e8b
Autor:
Maria Paximadis, Gregory Minevich, Robert Winchester, Diana B Schramm, Glenda E Gray, Gayle G Sherman, Ashraf H Coovadia, Louise Kuhn, Caroline T Tiemessen
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16541 (2011)
Numerous studies have suggested a role for natural killer (NK) cells in attenuation of HIV-1 disease progression via recognition by killer-cell immunoglobulin-like receptors (KIRs) of specific HLA class I molecules. The role of KIR and HLA class I ha
Externí odkaz:
https://doaj.org/article/176f224334cc4f4783e62aefb37487b6
Publikováno v:
South African Journal of Science, Vol 106, Iss 7/8 (2010)
For a short period of time in the early 20th century, indentured labourers from China were imported to work on the South African gold mines. The Raymond A. Dart Collection of Human Skeletons contains 36 skeletons sourced from a Chinese cemetery of th
Externí odkaz:
https://doaj.org/article/0face4f07ccb4eea887c90a6e05244cd
Autor:
Gayle G. Sherman, Yanhan Shen, Maria Paximadis, Karl-Günter Technau, Stephanie Shiau, Caroline T. Tiemessen, Louise Kuhn, Faeezah Patel, Elaine J. Abrams, Sizanani Mncube, Megan Burke, Renate Strehlau, Bianca Da Costa Dias, Shayne Loubser
Publikováno v:
Clin Infect Dis
Background Younger age of antiretroviral therapy (ART) initiation is associated with smaller viral reservoirs in perinatally acquired HIV-1 infection, but there is wide variability among early-treated infants. Predictors of this variability are not f