Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Maria Pawula"'
Autor:
Hemant M. Kocher, Bristi Basu, Fieke E. M. Froeling, Debashis Sarker, Sarah Slater, Dominic Carlin, Nandita M. deSouza, Katja N. De Paepe, Michelle R. Goulart, Christine Hughes, Ahmet Imrali, Rhiannon Roberts, Maria Pawula, Richard Houghton, Cheryl Lawrence, Yathushan Yogeswaran, Kelly Mousa, Carike Coetzee, Peter Sasieni, Aaron Prendergast, David J. Propper
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
All-trans retinoic acid - ATRA- is known to remodulate the stroma of pancreatic cancer in mice. Here, the authors carried out a Phase Ib trial in pancreatic patients and show that ATRA in combination with chemotherapy is a safe potential treatment fo
Externí odkaz:
https://doaj.org/article/7c7d3ad82a9e4375ae3a8da492b9ac27
Autor:
T. Isaac Johnson, Zhikai Wang, Claire M. Connell, James Thaventhiran, Ferdia A. Gallagher, Tobias Janowitz, Duncan I. Jodrell, Martin Smoragiewicz, Petros Barmpounakis, Lukasz Magiera, Douglas T. Fearon, Daniele Biasci, Irena Hudecova, Edmund Godfrey, Davina Gale, Nitzan Rosenfeld, Bristi Basu, Aarthi Gopinathan, Frances M. Richards, Lisa Bax, Maria Pawula, Rebecca Brais, Fraz Mir, Christopher Isherwood, Elizabeta C. Popa, Ya Gao
Publikováno v:
Br J Cancer
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Patients with microsatellite stable (MSS) pancreatic (PDA) or colorectal cancer (CRC) do not respond to immunotherapy with inhibitors of T cell checkpoints. A possible explanation is suggested by finding that cancer cells in these tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60c13d39cbdeb4e95c43c23820b334a
https://www.repository.cam.ac.uk/handle/1810/312459
https://www.repository.cam.ac.uk/handle/1810/312459
Autor:
Carike Coetzee, Hemant M. Kocher, Debashis Sarker, Yathushan Yogeswaran, Christine Hughes, Richard Houghton, Aaron Prendergast, Cheryl Lawrence, Peter Sasieni, Dominic Carlin, Katja N. De Paepe, Sarah Slater, David Propper, Michelle R. Goulart, Kelly Mousa, Maria Pawula, Ahmet Imrali, Fieke E. M. Froeling, Nandita M. deSouza, Bristi Basu, Rhiannon Roberts
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Pre-clinical models have shown that targeting pancreatic stellate cells with all-trans-retinoic-acid (ATRA) reprograms pancreatic stroma to suppress pancreatic ductal adenocarcinoma (PDAC) growth. Here, in a phase Ib, dose escalation and expansion, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f068ac6e5d57fb4bb65f61000a5664
Autor:
Purity Bundi, Emma Dean, Jeff Evans, Bruno Henrique Rala De Paula, James Thaventhiran, Richard J. A. Goodwin, Maria Pawula, Tatiana Hernandez, Subha Anand, Josephine Khan, Duncan I. Jodrell, Adrian Mander, Simon Smith, Gonzalez-Lopes Alberto, Eva M. Serrao, Sabita Islam, Vincenzo Graziano, Godfrey Edmund, Bristi Basu
Publikováno v:
Cancer Research. 81:CT214-CT214
Background:ATRiUM is a phase 1 trial to assess the safety, tolerability, pharmacokinetics and preliminary antitumour activity of ascending doses of combined therapy with the ATR inhibitor ceralasertib AZD6738 and gemcitabine, Using a Model based desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0f3f5d8ec71f1a27d6bad010c43bb8f
https://doi.org/10.1158/1538-7445.am2021-ct214
https://doi.org/10.1158/1538-7445.am2021-ct214
Autor:
Katja N. De Paepe, Dominic Carlin, Christine Hughes, Sarah Slater, Michelle R. Goulart, Yathushan Yogeswaran, Richard Houghton, Maria Pawula, Bristi Basu, Fieke E. M. Froeling, Kelly Mousa, Nandita M. deSouza, Debashis Sarker, Hemant M. Kocher, David Propper, Aaron Prendergast, Peter Sasieni, Ahmet Imrali, Cheryl Lawrence, Rhiannon Roberts, Carike Coetzee
Publikováno v:
Pancreatology. 20:e17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b7218df1442ee0265c2c9f11672ae95
https://doi.org/10.1016/j.pan.2020.10.009
https://doi.org/10.1016/j.pan.2020.10.009
Autor:
Timothy Sangster, Stéphane Bronner, Rachel Green, John Allinson, Scott Reuschel, Jaap Wieling, Mike Losauro, Michele Malone, Richard LeLacheur, Robert Nicholson, William Nowatzke, Mike Buonarati, Mark Cameron, Colin Pattison, Tammy Harter, Rafiq Islam, Jake Harman, Laura Cojocaru, Maria Pawula, Steve Lowes, Richard Hougton, Christine Schiebl, Petra Struwe, Wei Garofolo, Dominique Gouty, Fabio Garofolo, Philippe Couerbe, Theo de Boer, Roger Hayes
Publikováno v:
Bioanalysis. 4:2439-2446
The 5th GCC in Barcelona (Spain) and 6th GCC in San Antonio (TX, USA) events provided a unique opportunity for CRO leaders to openly share opinions and perspectives, and to agree upon recommendations on biomarker bioanalytical method validation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7efa86c3e8b8c2d918c23722c49ca0
https://doi.org/10.4155/bio.12.197
https://doi.org/10.4155/bio.12.197
Autor:
Rachel Green, Romuald Sable, Daniel Tang, Thomas Zimmerman, Stuart Best, Tammy Harter, Dieter Zimmer, Timothy Sangster, John Maltas, Maria Pawula, Chiara Bigogno, Jim Hillier, Christoff Siethoff, Chris Cox, Colin Pattison, Lois Folguera, Massimo Breda, Lee Goodwin, Dick Schoutsen, Mira Doig, Christine Schiebl, Petra Struwe, Maria Cruz Caturla, Wei Garofolo, Richard Houghton, Fabio Garofolo, Mark Boterman, Rudi Segers, Philippe Couerbe, Theo de Boer
Publikováno v:
Bioanalysis. 4:1723-1730
The Global CRO Council for Bioanalysis (GCC) was formed in an effort to bring together many senior-level representatives of CROs to openly discuss bioanalysis and the regulatory challenges, many of them unique to the outsourcing industry. CROs are un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aad1b765808699e23ef1f0a68dbe9a6
https://doi.org/10.4155/bio.12.172
https://doi.org/10.4155/bio.12.172
Autor:
Jim Hillier, Chiara Bigogno, Mira Doig, Mike Allen, Theo de Boer, Mohammed Bouhajib, Chris Cox, Ronald Shoup, Dieter Zimmer, Roger Hayes, John Maltas, Masood Bhatti, Maria Cruz Caturla, Michele Malone, Jim Jersey, Timothy Sangster, Romuald Sable, Massimo Breda, Philippe Couerbe, Saadya Fatmi, Lois Folguera, Lee Goodwin, Alan Breau, Daniel Tang, Paula Jardieu, Shane Karnik, Ann Levesque, Dick Schoutsen, Isabelle Dumont, Zhongping John Lin, Wei Garofolo, Ming Hung Lin, Johanne Bouchard, Xinping Fang, Christine Schiebl, Curtis Sheldon, Carmen Dilger, Steve Lowes, Joelle Guittard, Petra Struwe, Suzanne Martinez, Mark Boterman, Maria Pawula, Shane Needham, Fabio Garofolo, Tim Lansing, Richard Houghton, Marc Moussallie, William DeMaio, Jenny Lin, Tammy Harter, Laura Cojocaru, Kirk R. Smith, Colin Pattison, Rand Jenkins, Richard Lundberg, Rachel Green, Robert Nicholson, Leonardo de Souza Teixeira, James Truog, Stuart Best, Farhad Sayyarpour, Rafiq Islam, Rudi Segers, Christoph Siethoff, Thais Rocha, Thomas Zimmermann, Sofi Gagnon-Carignan
Publikováno v:
Bioanalysis. 4:651-660
Senior representatives of GCC member companies have thoroughly evaluated and discussed the new European Medicines Agency (EMA; July 2011 [1]) Guideline on Bioanalytical Method Validation (BMV), during the 4th GCC (23 October 2011, Washington DC, USA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a6e4fba87d49a60578af519fd3172a
https://doi.org/10.4155/bio.12.18
https://doi.org/10.4155/bio.12.18
Autor:
Dick Schoutsen, Tammy Harter, Quinton Claassen, Rachel Green, Bernard Jeanbaptiste, Eileen Collins, Wei Garofolo, Philippe Couerbe, Fabio Garofolo, Mark Seymour, Petra Struwe, Maria Cruz Caturla, Peter White, Jim Hillier, Jaap Wieling, Suzanne Riches, Richard Houghton, John Maltas, Massimo Breda, Maria Pawula, Timothy Sangster, Thomas Zimmerman
Publikováno v:
Bioanalysis. 3:2721-2727
The 3rd Global CRO Council Closed Forum was held on the 3rd and 4th July 2011 in Guildford, United Kingdom, in conjunction with the 19th International Reid Bioanalytical Forum. In attendance were 21 senior-level representatives from 19 CROs on behalf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::251089e96d77847b770dfad086186855
https://doi.org/10.4155/bio.11.242
https://doi.org/10.4155/bio.11.242
Publikováno v:
Talanta. 146
A surface plasmon resonance (SPR) sensor developed for the rapid, sensitive and specific detection of cardiac troponin T (cTnT) in serum samples is reported in this work. An extensive optimisation of assay parameters was conducted to achieve optimal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9761624d6b1774ef16e436fa6dfeb285
https://pubmed.ncbi.nlm.nih.gov/26695335
https://pubmed.ncbi.nlm.nih.gov/26695335