Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Maria Paola Giovannoni"'
Autor:
Letizia Crocetti, Andrei I. Khlebnikov, Gabriella Guerrini, Igor A. Schepetkin, Fabrizio Melani, Maria Paola Giovannoni, Mark T. Quinn
Publikováno v:
Molecules, Vol 29, Iss 11, p 2421 (2024)
Chronic inflammation contributes to a number of diseases. Therefore, control of the inflammatory response is an important therapeutic goal. To identify novel anti-inflammatory compounds, we synthesized and screened a library of 80 pyrazolo[1,5-a]quin
Externí odkaz:
https://doaj.org/article/007794058c7e431b94cac6664e57eecf
Autor:
Valentina Ferrara, Alessandra Toti, Elena Lucarini, Carmen Parisio, Laura Micheli, Clara Ciampi, Francesco Margiotta, Letizia Crocetti, Claudia Vergelli, Maria Paola Giovannoni, Lorenzo Di Cesare Mannelli, Carla Ghelardini
Publikováno v:
Antioxidants, Vol 12, Iss 6, p 1207 (2023)
Rheumatoid arthritis is an autoimmune disorder that causes chronic joint pain, swelling, and movement impairment, resulting from prolonged inflammation-induced cartilage and bone degradation. The pathogenesis of RA, which is still unclear, makes diag
Externí odkaz:
https://doaj.org/article/62795beb034e4682ba2b39f3cc1a33eb
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/9a8e68be2274404096e07de5b871dbd2
Autor:
Letizia Crocetti, Gabriella Guerrini, Fabrizio Melani, Claudia Vergelli, Maria Paola Giovannoni
Publikováno v:
Molecules, Vol 28, Iss 7, p 3054 (2023)
The isosteric replacement of the benzene with thiophene ring is a chemical modification widely applied in medicinal chemistry. Several drugs containing the thiophene ring are marketed for treating various pathologies (osteoporosis, peripheral artery
Externí odkaz:
https://doaj.org/article/0e06483d87c64f6582d77899b45ca2dc
Repurposing strategies on pyridazinone-based series by pharmacophore- and structure-driven screening
Autor:
Giuseppe Floresta, Letizia Crocetti, Maria Paola Giovannoni, Pierfrancesco Biagini, Agostino Cilibrizzi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1137-1144 (2020)
We report here in silico repurposing studies on 52 new pyridazinone-based small-molecules through inverse virtual screening (iVS) methodologies. These analogues were originally designed as formyl peptide receptor (FPR) ligands. As it is sometimes the
Externí odkaz:
https://doaj.org/article/18bd070a6688466eaead8b4ac1584774
Autor:
Letizia Crocetti, Giuseppe Floresta, Chiara Zagni, Divya Merugu, Francesca Mazzacuva, Renan Rodrigues de Oliveira Silva, Claudia Vergelli, Maria Paola Giovannoni, Agostino Cilibrizzi
Publikováno v:
Pharmaceuticals, Vol 15, Iss 11, p 1335 (2022)
Fatty acid binding protein (FABP4) inhibitors are of synthetic and therapeutic interest and ongoing clinical studies indicate that they may be a promise for the treatment of cancer, as well as other diseases. As part of a broader research effort to d
Externí odkaz:
https://doaj.org/article/9b4e32591ce1407daa77833857b5ce5d
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 44-50 (2019)
This study reports the application of inverse virtual screening (iVS) methodologies to identify cellular proteins as suitable targets for a library of heterocyclic small-molecules, with potential pharmacological implications. Standard synthetic proce
Externí odkaz:
https://doaj.org/article/7f40673e7dfb42fb8b8ad9670c7d247e
Publikováno v:
Molecules, Vol 27, Iss 15, p 4964 (2022)
Since the early 1980s, phosphodiesterase 4 (PDE4) has been an attractive target for the treatment of inflammation-based diseases. Several scientific advancements, by both academia and pharmaceutical companies, have enabled the identification of many
Externí odkaz:
https://doaj.org/article/24c564b29098400d8cb0133330f27907
Autor:
Niccolo Cantini, Igor A. Schepetkin, Nadezhda V. Danilenko, Andrei I. Khlebnikov, Letizia Crocetti, Maria Paola Giovannoni, Liliya N. Kirpotina, Mark T. Quinn
Publikováno v:
Molecules, Vol 27, Iss 12, p 3749 (2022)
Persistent inflammation contributes to a number of diseases; therefore, control of the inflammatory response is an important therapeutic goal. In an effort to identify novel anti-inflammatory compounds, we screened a library of pyridazinones and stru
Externí odkaz:
https://doaj.org/article/81dcaa431a4f42ebb5c369ad529d708c
Autor:
Letizia Crocetti, Maria Paola Giovannoni, Niccolò Cantini, Gabriella Guerrini, Claudia Vergelli, Igor A. Schepetkin, Andrei I. Khlebnikov, Mark T. Quinn
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Human neutrophil elastase (HNE) is involved in a number of essential physiological processes and has been identified as a potential therapeutic target for treating acute and chronic lung injury. Nevertheless, only one drug, Sivelestat, has been appro
Externí odkaz:
https://doaj.org/article/1b275252690e4f0c89bfd76862ba0cff