Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Maria P. Alcolea"'
Autor:
Albert Herms, David Fernandez-Antoran, Maria P. Alcolea, Argyro Kalogeropoulou, Ujjwal Banerjee, Gabriel Piedrafita, Emilie Abby, Jose Antonio Valverde-Lopez, Inês S. Ferreira, Stefan C. Dentro, Swee Hoe Ong, Bartomeu Colom, Kasumi Murai, Charlotte King, Krishnaa Mahbubani, Kourosh Saeb-Parsy, Alan R Lowe, Moritz Gerstung, Philip H Jones
Studying long-term biological processes such as the colonization of aging epithelia by somatic mutant clones has been slowed by the lack of suitable culture systems. Here we describe epithelioids, a facile, cost-effective method of culturing multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be52034b8d198820e25cae713558400a
https://doi.org/10.1101/2023.01.03.522589
https://doi.org/10.1101/2023.01.03.522589
Autor:
Kata Krizic, Kim B. Jensen, Maria P. Alcolea, Kevin J. Chalut, Seungmin Han, Svetlana Ulyanchenko, Christophe M. Verstreken, Ramiro Iglesias-Bartolome, Jamie McGinn, Adrien Hallou, Benjamin D. Simons, Frances J. England
Publikováno v:
Nature cell biology
Epithelial cells rapidly adapt their behaviour in response to increasing tissue demands. However, the processes that finely control these cell decisions remain largely unknown. The postnatal period covering the transition between early tissue expansi
Autor:
Swee Hoe Ong, Joanna C. Fowler, Charlotte King, Michael W. J. Hall, Moritz Gerstung, Bartomeu Colom, Philip H. Jones, Gabriel Piedrafita, Sood R, Agnieszka Wabik, Stefan C. Dentro, Maria P. Alcolea, Inigo Martincorena, Benjamin A. Hall, Albert Herms
Publikováno v:
Nature Genetics. 52:604-614
During aging, progenitor cells acquire mutations, which may generate clones that colonize the surrounding tissue. By middle age, normal human tissues, including the esophageal epithelium (EE), become a patchwork of mutant clones. Despite their releva
Autor:
Charlotte King, Stefan C. Dentro, Bartomeu Colom, Krishnaa T. Mahbubani, Moritz Gerstung, Maria P. Alcolea, David Fernandez-Antoran, Philip H. Jones, Sood R, Benjamin A. Hall, Albert Herms, Kourosh Saeb-Parsy, Swee Hoe Ong, Joanna C. Fowler
SummaryHuman epithelial tissues accumulate cancer-driver mutations with age1–7, yet tumor formation remains rare. The positive selection of these mutations argues they alter the behavior and fitness of proliferating cells8–10. Hence, normal adult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b35042dc701d74fe8b0b499cea711cc
https://doi.org/10.1101/2021.06.25.449880
https://doi.org/10.1101/2021.06.25.449880
Autor:
Jamie McGinn, Maria P. Alcolea, Frances J. England, Christophe M. Verstreken, Svetlana Ulyanchenko, Seungmin Han, Kevin J. Chalut, Adrien Hallou, Ramiro Iglesias-Bartolome, Kim B. Jensen, Kata Krizic, Benjamin D. Simons
Epithelial cells are highly dynamic and can rapidly adapt their behavior in response to tissue perturbations and increasing tissue demands. However, the processes that finely control these responses and, particularly, the mechanisms that ensure the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c50af30ab53a0341274b0b5b78c56193
https://doi.org/10.1101/2021.02.03.428820
https://doi.org/10.1101/2021.02.03.428820
Autor:
Berthold Göttgens, Fernando J Calero-Nieto, Irina Mohorianu, Seungmin Han, Maria T. Bejar, Maria P. Alcolea, Bartomeu Colom, Paula Jimenez-Gomez, Ilias Moutsopoulos, Benjamin D. Simons
Publikováno v:
bioRxiv
The ability of epithelial cells to rewire their cell fate program beyond their physiological repertoire has become a new paradigm in stem cell biology. This plasticity leaves behind the concept of strict stem cell hierarchies, opening up new exciting
Autor:
Stefan C. Dentro, Charlotte King, Joanna C. Fowler, Albert Herms, Bartomeu Colom, Maria P. Alcolea, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, Benjamin A. Hall, David Fernandez-Antoran, Moritz Gerstung, Sood R, Michael W. J. Hall, Philip H. Jones, Gabriel Piedrafita, Swee Hoe Ong
Publikováno v:
Nature. 598(7881)
Human epithelial tissues accumulate cancer-driver mutations with age1–9, yet tumour formation remains rare. The positive selection of these mutations suggests that they alter the behaviour and fitness of proliferating cells10–12. Thus, normal adu
Autor:
Bartomeu, Colom, Maria P, Alcolea, Gabriel, Piedrafita, Michael W J, Hall, Agnieszka, Wabik, Stefan C, Dentro, Joanna C, Fowler, Albert, Herms, Charlotte, King, Swee Hoe, Ong, Roshan K, Sood, Moritz, Gerstung, Inigo, Martincorena, Benjamin A, Hall, Philip H, Jones
Publikováno v:
Nature genetics. 52(6)
During aging, progenitor cells acquire mutations, which may generate clones that colonize the surrounding tissue. By middle age, normal human tissues, including the esophageal epithelium (EE), become a patchwork of mutant clones. Despite their releva
Autor:
Maria P. Alcolea, Catherine R. M. Fitzpatrick, Sarah E. Bohndiek, Travis W. Sawyer, Rebecca C. Fitzgerald, Philip H. Jones, James Joseph, Massimiliano di Pietro, Timothy D. Wilkinson, Calum Williams, George S. D. Gordon
Publikováno v:
Journal of Biomedical Optics
Phase and polarization of coherent light are highly perturbed by interaction with microstructural changes in premalignant tissue, holding promise for label-free detection of early tumors in endoscopically accessible tissues such as the gastrointestin
Autor:
Maria P. Alcolea
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783319691930
Oesophageal cancer remains one of the least explored malignancies. However, in recent years its increasing incidence and poor prognosis have stimulated interest from the cancer community to understand the pathways to the initiation and progression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eaad1374a003c77aa738dc65f104086
https://doi.org/10.1007/978-3-319-69194-7_10
https://doi.org/10.1007/978-3-319-69194-7_10