Zobrazeno 1 - 10 of 82 pro vyhledávání: '"Maria P Limberis"'
1
Akademický článek
Adeno-associated virus-mediated expression of human butyrylcholinesterase to treat organophosphate poisoning.
Autor: Vibhor Gupta, C Linn Cadieux, Deirdre McMenamin, C Angelica Medina-Jaszek, Muhammad Arif, Omua Ahonkhai, Erik Wielechowski, Maryam Taheri, Yan Che, Tamara Goode, Maria P Limberis, Mingyao Li, Douglas M Cerasoli, Anna P Tretiakova, James M Wilson
Publikováno v: PLoS ONE, Vol 14, Iss 11, p e0225188 (2019)
Rare diseases defined by genetic mutations are classic targets for gene therapy. More recently, researchers expanded the use of gene therapy in non-clinical studies to infectious diseases through the delivery of vectorized antibodies to well-defined
Externí odkaz: https://doaj.org/article/af3d61c7a5b44e0bb6363de47de712bb
Zobrazit plný text záznamu
2
Akademický článek
A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis
Autor: Eric WFW Alton, David K Armstrong, Deborah Ashby, Katie J Bayfield, Diana Bilton, Emily V Bloomfield, A Christopher Boyd, June Brand, Ruaridh Buchan, Roberto Calcedo, Paula Carvelli, Mario Chan, Seng H Cheng, David S Collie, Steve Cunningham, Heather E Davidson, Gwyneth Davies, Jane C Davies, Lee A Davies, Maria H Dewar, Ann Doherty, Jackie Donovan, Natalie S Dwyer, Hala I Elgmati, Rosanna F Featherstone, Jemyr Gavino, Sabrina Gea-Sorli, Duncan M Geddes, James SR Gibson, Deborah R Gill, Andrew P Greening, Uta Griesenbach, David M Hansell, Katharine Harman, Tracy E Higgins, Samantha L Hodges, Stephen C Hyde, Laura Hyndman, J Alastair Innes, Joseph Jacob, Nancy Jones, Brian F Keogh, Maria P Limberis, Paul Lloyd-Evans, Alan W Maclean, Michelle C Manvell, Dominique McCormick, Michael McGovern, Gerry McLachlan, Cuixiang Meng, M Angeles Montero, Hazel Milligan, Laura J Moyce, Gordon D Murray, Andrew G Nicholson, Tina Osadolor, Javier Parra-Leiton, David J Porteous, Ian A Pringle, Emma K Punch, Kamila M Pytel, Alexandra L Quittner, Gina Rivellini, Clare J Saunders, Ronald K Scheule, Sarah Sheard, Nicholas J Simmonds, Keith Smith, Stephen N Smith, Najwa Soussi, Samia Soussi, Emma J Spearing, Barbara J Stevenson, Stephanie G Sumner-Jones, Minna Turkkila, Rosa P Ureta, Michael D Waller, Marguerite Y Wasowicz, James M Wilson, Paul Wolstenholme-Hogg, on behalf of the UK Cystic Fibrosis Gene Therapy Consortium
Publikováno v: Efficacy and Mechanism Evaluation, Vol 3, Iss 5 (2016)
Background: Cystic fibrosis (CF) is a chronic, life-limiting disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene leading to abnormal airway surface ion transport, chronic lung infections, inflammation and eventual re
Externí odkaz: https://doaj.org/article/09b29fe1b155492fba24a177fe4be24c
Zobrazit plný text záznamu
3
Akademický článek
Durable transgene expression and efficient re-administration after rAAV2.5T-mediated fCFTRΔR gene delivery to adult ferret lungs
Autor: Yinghua Tang, Mehrnoosh Ebadi, Junying Lei, Zehua Feng, Shahab Fakhari, Peipei Wu, Mark D. Smith, Maria P. Limberis, Roland Kolbeck, Katherine J. Excoffon, Ziying Yan, John F. Engelhardt
Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101244- (2024)
The dosing interval for effective recombinant adeno-associated virus (rAAV)-mediated gene therapy of cystic fibrosis lung disease remains unknown. Here, we assessed the durability of rAAV2.5T-fCFTRΔR-mediated transgene expression and neutralizing an
Externí odkaz: https://doaj.org/article/27a6b1d9b32d4d5fbd5e3361073b18ed
Zobrazit plný text záznamu
4
Akademický článek
Immunosuppression reduces rAAV2.5T neutralizing antibodies that limit efficacy following repeat dosing to ferret lungs
Autor: Yinghua Tang, Shahab Fakhari, Eric D. Huntemann, Zehua Feng, Peipei Wu, William Y. Feng, Junying Lei, Feng Yuan, Katherine J. Excoffon, Kai Wang, Maria P. Limberis, Roland Kolbeck, Ziying Yan, John F. Engelhardt
Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 70-80 (2023)
The efficacy of redosing the recombinant adeno-associated virus (rAAV) vector rAAV2.5T to ferret lung is limited by AAV neutralizing antibody (NAb) responses. While immunosuppression strategies have allowed for systemic rAAV repeat dosing, their util
Externí odkaz: https://doaj.org/article/1cbaa351bc964c2ea2b39626805cbbeb
Zobrazit plný text záznamu
5
Gene Therapeutics for Surfactant Dysfunction Disorders: Targeting the Alveolar Type 2 Epithelial Cell
Autor: Sneha Sitaraman, Konstantinos-Dionysios Alysandratos, Jennifer A. Wambach, Maria P. Limberis
Publikováno v: Human gene therapy. 33(19-20)
Genetic disorders of surfactant dysfunction result in significant morbidity and mortality, among infants, children, and adults. Available medical interventions are limited, nonspecific, and generally ineffective. As such, the need for effective thera
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d52302e6b7bfb551175abc5f453729d
https://pubmed.ncbi.nlm.nih.gov/36166236
Zobrazit plný text záznamu
8
Data from Intrathecal Viral Vector Delivery of Trastuzumab Prevents or Inhibits Tumor Growth of Human HER2-Positive Xenografts in Mice
Autor: James M. Wilson, Mingyao Li, Anna P. Tretiakova, Maria P. Limberis, Laura K. Richman, Peter Bell, William T. Rothwell
Breast cancer brain metastases are a deadly sequela of primary breast tumors that overexpress human epidermal growth factor receptor 2 (HER2); median survival for patients with these tumors is 10 to 13 months from the time of diagnosis. Current treat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d73c08443b043559ce7540dd478710
https://doi.org/10.1158/0008-5472.c.6510458
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje