Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Maria O. Vannozzi"'
Autor:
Maria O. Vannozzi, Maurizio Nicodemo, Gianluca Damonte, Andrea Armirotti, Marco Venturini, Lucia Cavallini, Gianluigi Lunardi
Publikováno v:
Clinical Therapeutics. 31:1812-1819
Background: Intravenous temsirolimus, an inhibitor of the mammalian target of rapamycin (mTOR), is approved for the treatment of advanced renal cell carcinoma (RCC). Sirolimus, the principal metabolite of temsirolimus in humans, also exhibits mTOR in
Autor:
Massimo Ottone, Antonio Zicca, Maria A. Mariggiò, Vittorio Bocchini, Maurizio Viale, Maria O. Vannozzi, Gabriele Caviglioli, Sergio Cafaggi
Publikováno v:
European Journal of Pharmacology. 442:265-272
In preceding papers, we proposed that procainamide hydrochloride, a class I antiarrhythmic agent, was able to protect mice and rats from cisplatin-induced nephrotoxicity and that it could exert its action through accumulation in kidneys followed by c
Autor:
Franco De Cian, Mauro Esposito, E. Spessa, Giovanni Battista Ratto, Antonella Alloisio, Maria O. Vannozzi, Dario Civalleri
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 117(4):759-765
Introduction: Malignant pleural mesothelioma is an ideal model for testing new locoregional multimodality approaches because of its aggressive local behavior. Methods: This study was planned to investigate the feasibility, safety, and pharmacokinetic
Autor:
M. Viale, Maria O. Vannozzi, Brunella Parodi, Franco Merlo, Sergio Cafaggi, Maria Teresa Esposito
Publikováno v:
European Journal of Cancer. 32:2327-2333
The administration of combinations of platinum compounds is considered as a useful alternative therapeutic strategy to avoid the complications of toxic events during cancer chemotherapy in order to obtain a therapeutic advantage. On the basis of prev
Autor:
Mauro Esposito, E. Spessa, Damiano Zaccheo, Giovanni Battista Ratto, Maria O. Vannozzi, F. Scarano, M. Canepa, P. Romano, G. Fantino, Dario Civalleri, R. Palumbo, Salvatore Toma, F. De Cian, Giancarlo Passerone
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 112(3):614-622
A multimodality approach including operation and isolated lung perfusion with platinum was used in six patients with lung metastases from soft tissue sarcomas. Staged thoracotomies were used in two patients with bilateral lesions. The inclusion crite
Autor:
Cristina Barzacchi, Maria O. Vannozzi, Gianmauro Numico, Maurizio Viale, Mauro Esposito, Nobile Mt, O. Sanguineti
Publikováno v:
Clinical Drug Investigation. 12:39-45
As part of a clinical trial of 5-fluorouracil (5-FU) administered as a 24-hour intravenous infusion in patients with colorectal carcinoma, pharmacokinetic studies of (6S)-leucovorin [(6S)-LV] and its major metabolite 5-methyl-tetrahydrofolate (5-CH3-
Autor:
Roberto Lerza, Mauro Esposito, Mencoboni M, Giuseppe Bogliolo, Maria O. Vannozzi, Ivo Pannacciulli, Giovan Battista Bottino, Cerruti A, Castello G, Luca Gogioso
Publikováno v:
Drug Investigation. 8:352-360
Carboplatin 360 mg/m2 was administered intrapleurally to 4 patients with malignant pleural effusion. Simultaneous pleural fluid and plasma samples were collected at various times after treatment to measure the total and filterable levels of platinum.
Autor:
Giovan Battista Bottino, Maria O. Vannozzi, Roberto Lerza, Mauro Esposito, Ivo Pannacciulli, Giuseppe Bogliolo
Publikováno v:
Cancer. 73:79-84
Background. The authors report a feasibility study of intrapleural cisplatin in a patient with inoperable malignant pleural mesothelioma. Methods. Total and filterable platinum in pleural effusion and in plasma were monitored for two intrapleural cou
Autor:
Franco De Cian, P. Romano, Mauro Esposito, Damiano Zaccheo, Giovanni B. Ratto, Marco Canepa, Leprini A, Dario Civalleri, Maria O. Vannozzi
Publikováno v:
Cancer. 71:2962-2970
Background. This research work was planned to evaluate the soundness of in situ lung perfusion as a regional administration modality of chemotherapeutic agents. Methods. Sixteen pigs were randomly divided into four groups and received cisplatin (2.5
Autor:
Maurizio Viale, Brunella Parodi, Sergio Cafaggi, Maria A. Mariggiò, Massimo Ottone, Václav Mandys, Maria O. Vannozzi
Publikováno v:
Investigational new drugs. 22(1)
Cis-diaminechloro-[2-(diethylamino) ethyl 4-amino-benzoate, N(4)]-chloride platinum (II) monohydrochloride monohydrate (DPR) is a new platinum triamine complex obtained from the synthesis of cisplatin and procaine. In this paper we analyzed, adopting