Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Maria O. Hernandez"'
Autor:
Marwa M. Afifi, Adrijana Crncec, James A. Cornwell, Christophe Cataisson, Debasish Paul, Laila M. Ghorab, Maria O. Hernandez, Madeline Wong, Noemi Kedei, Steven D. Cappell
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113079- (2023)
Summary: Cells can irreversibly exit the cell cycle and become senescent to safeguard against uncontrolled proliferation. While the p53-p21 and p16-Rb pathways are thought to mediate senescence, they also mediate reversible cell cycle arrest (quiesce
Externí odkaz:
https://doaj.org/article/36a760b5063847ea9f932b1bae680c03
Publikováno v:
Toxins, Vol 3, Iss 9, Pp 1131-1145 (2011)
The entry of ricin toxin into macrophages and certain other cell types in the spleen and liver results in toxin-induced inflammation, tissue damage and organ failure. It has been proposed that uptake of ricin into macrophages is facilitated by the ma
Externí odkaz:
https://doaj.org/article/4d4cd3ed3a5340a1924b7233399a919a
Autor:
Yongmei Zhao, Michael C. Kelly, Jeremy L. Davis, Bradford J. Wood, Marshonna Forgues, Lichun Ma, Limin Wang, Dana A. Dominguez, David E. Kleiner, Maria O. Hernandez, Julián Candia, Jonathan M. Hernandez, Bao Tran, Tim F. Greten, Subreen A. Khatib, Ching Wen Chang, Xin Wei Wang, Sophia Heinrich
Publikováno v:
Hepatobiliary Surg Nutr
Background & Aims Intratumor molecular heterogeneity is a key feature of tumorigenesis and is linked to treatment failure and patient prognosis. Herein, we aimed to determine what drives tumor cell evolution by performing single-cell transcriptomic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e244cad78fdeeb2d1bffa3df2d3c49d2
https://doi.org/10.1016/j.jhep.2021.06.028
https://doi.org/10.1016/j.jhep.2021.06.028
Autor:
Joseph K. Lim, Melinda L. Irwin, Antoinette M. Stroup, Hwai I. Yang, Shiori Suzuki, Brenda Y. Hernandez, Yoichiro Kamatani, Claire E. Thomas, Jian-Min Yuan, Chiea Chuen Khor, Atsushi Goto, Mindie H. Nguyen, Harvey A. Risch, Hongyu Zhao, Woon-Puay Koh, Zhanwei Wang, Chizu Tanikawa, Mei Hsuan Lee, Xin Wei Wang, Robert S. Brown, Karen Pawlish, Jill Koshiol, Maarit Tiirikainen, Lopa Mishra, Yi Shen, Herbert Yu, Kirti Shetty, Anuradha Budhu, Dean L. Mann, Koichi Matsuda, Yu Han Huang, Lingeng Lu, Xiaomei Ma, Maria O. Hernandez, Tamar H. Taddei, Linda Lou Wong, Maria A. Guarnera, Motoki Iwasaki, Marshonna Forgues
Publikováno v:
JGH Open: An Open Access Journal of Gastroenterology and Hepatology
JGH Open, Vol 5, Iss 12, Pp 1363-1372 (2021)
JGH Open, Vol 5, Iss 12, Pp 1363-1372 (2021)
Background and Aim Chronic hepatitis C virus (HCV) infection, long‐term alcohol use, cigarette smoking, and obesity are the major risk factors for hepatocellular carcinoma (HCC) in the United States, but the disease risk varies substantially among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b414077e83b02828d58f312052803dd2
http://europepmc.org/articles/PMC8674550
http://europepmc.org/articles/PMC8674550
Autor:
Lichun Ma, Jonathan M. Hernandez, Marshonna Forgues, Yongmei Zhao, Michael C. Kelly, Dana A. Dominguez, Jeremy L. Davis, Sophia Heinrich, Bradford J. Wood, David E. Kleiner, Xin Wei Wang, Julián Candia, Bao Tran, Maria O. Hernandez, Ching Wen Chang, Limin Wang, Tim F. Greten
SUMMARYTumor evolution is a key feature of tumorigenesis and plays a pivotal role in driving intratumor heterogeneity, treatment failure and patients’ prognosis. Here we performed single-cell transcriptome profiling of 46 primary liver cancers from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96b17fb25038d71ea9e696126e89580c
https://doi.org/10.1101/2020.08.18.254748
https://doi.org/10.1101/2020.08.18.254748
Autor:
Lichun Ma, Xin Wei Wang, Ching Wen Chang, Dana A. Dominguez, S Franck, Yongmei Zhao, Maria O. Hernandez, Marshonna Forgues, Bao Tran, Limin Wang, David E. Kleiner, Michael T. Kelly, Jonathan M. Hernandez, Jeremy L. Davis, Bradford J. Wood, Tim F. Greten, Julián Candia
Publikováno v:
Cancer Research. 80:PR04-PR04
Tumor evolution is a key feature intrinsic to tumor biology and contributes to intratumor heterogeneity, escape of immune surveillance, treatment failure, and patients’ prognosis. The evolutionary process of tumor is driven by selecting favorable p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da2688e8b86780ed73252ae0b4cbedbc
https://doi.org/10.1158/1538-7445.tumhet2020-pr04
https://doi.org/10.1158/1538-7445.tumhet2020-pr04
Autor:
Lichun Ma, Xin Wei Wang, Maria O. Hernandez, Jeremy L. Davis, Yongmei Zhao, David E. Kleiner, Michael C. Kelly, Bradford J. Wood, Bao Tran, Monika Mehta, Kris Ylaya, Stephen M. Hewitt, Zachary Rae, Tim F. Greten, Jonathan M. Hernandez, Sean P. Martin
Publikováno v:
Cancer Research. 80:1500-1500
Tumor cell biodiversity is a major contributing factor to therapeutic failures and lethal outcomes of solid malignancies. Primary liver cancer, comprising mainly hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), is the second
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29fd999e83fb820eac925752a44760e8
https://doi.org/10.1158/1538-7445.am2020-1500
https://doi.org/10.1158/1538-7445.am2020-1500
Autor:
Jeremy L. Davis, Maria O. Hernandez, Yotsawat Pomyen, Xin Wei Wang, Bao Tran, Monika Mehta, Ferenc Livak, Yelena Levin, Jyoti Shetty, Anuradha Budhu, Wei Tang, Hongping Zheng, Tim F. Greten, Caiyi Li, Yongmei Zhao, Hien Dang
Intratumor molecular heterogeneity of hepatocellular carcinoma is partly attributed to the presence of hepatic cancer stem cells (CSCs). Different CSC populations defined by various cell surface markers may contain different oncogenic drivers, posing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0316de3f2eb20cb34832760f9a6ec5
https://europepmc.org/articles/PMC6033650/
https://europepmc.org/articles/PMC6033650/
Autor:
Jeremy L. Davis, Bradford J. Wood, Xin Wei Wang, Kris Ylaya, Bao Tran, Yongmei Zhao, David E. Kleiner, Michael C. Kelly, Monika Mehta, Zachary Rae, Sean P. Martin, Jonathan M. Hernandez, Lichun Ma, Tim F. Greten, Stephen M. Hewitt, Maria O. Hernandez
Publikováno v:
Cancer Cell
Summary Cellular diversity in tumors is a key factor for therapeutic failures and lethal outcomes of solid malignancies. Here, we determined the single-cell transcriptomic landscape of liver cancer biospecimens from 19 patients. We found varying degr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55ec4eea98db2c81c81db72a52e7193
https://doi.org/10.1016/j.ccell.2019.08.007
https://doi.org/10.1016/j.ccell.2019.08.007
Publikováno v:
Toxins
Toxins; Volume 3; Issue 9; Pages: 1131-1145
Toxins, Vol 3, Iss 9, Pp 1131-1145 (2011)
Toxins; Volume 3; Issue 9; Pages: 1131-1145
Toxins, Vol 3, Iss 9, Pp 1131-1145 (2011)
The entry of ricin toxin into macrophages and certain other cell types in the spleen and liver results in toxin-induced inflammation, tissue damage and organ failure. It has been proposed that uptake of ricin into macrophages is facilitated by the ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d881bf1e345ac30c5738190eac2eaa
https://doi.org/10.3390/toxins3091131
https://doi.org/10.3390/toxins3091131