Oligomerization of a Glucagon-like Peptide 1 Analog: Bridging Experiment and Simulations

Autor: Anne M. Scharff-Poulsen, Maria Northved Elf-Lind, Pernille Sønderby, Pernille Harris, Günther H.J. Peters, Tine Maja Frederiksen, Line A. Ryberg, Jens T. Bukrinski

Publikováno v: Frederiksen, T M, Sønderby, P, Ryberg, LA, Harris, P, Bukrinski, JT, Scharff-Poulsen, AM, Elf-Lind, M N & Peters, G H J 2015, ' Oligomerization of a Glucagon-like Peptide 1 Analog: Bridging Experiment and Simulations ', Biophysical Journal, vol. 109, no. 6, pp. 1202-1213 . https://doi.org/10.1016/j.bpj.2015.07.051

The glucagon-like peptide 1 (GLP-1) analog, liraglutide, is a GLP-1 agonist and is used in the treatment of type-2 diabetes mellitus and obesity. From a pharmaceutical perspective, it is important to know the oligomerization state of liraglutide with

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https://doi.org/10.1016/j.bpj.2015.07.051

Binding of Neurotransmitters to Lipid Membranes

Autor: Gustavo Velardez, Nicolaj Cruys-Bagger, Peter Westh, Jesper J. Madsen, Chunhua Wang, Mikkel Werge, Maria Northved Elf-Lind, Günther H.J. Peters

Publikováno v: Peters, G H J, Werge, M, Elf-Lind, M N, Wang, C, Cruys-Bagger, N, Velardez, G, Madsen, J J & Westh, P 2014, ' Binding of Neurotransmitters to Lipid Membranes ', Biophysical Journal, vol. 106, no. 2, Supplement 1 . https://doi.org/10.1016/j.bpj.2013.11.2562

We have performed a series of thermodynamic measurements and molecular dynamics (MD) simulations to study the interactions between the neurotransmitters (NTs) 5-hydroxytryptamine (5-HT), g-aminobutyrate (GABA), glycine (GLY), acetylcholine (ACH) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d412f84db74618ca0c2d5cd47557e7