Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Maria N. Preobrazhenskaya"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 452-456 (2017)
Clarithromycin (active against Gram positive infections) and 1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole derivatives (effective for Gram negative microbes) are the ligands of bacterial RNA. The antimicrobial activities of these benzoxaboroles linked
Externí odkaz:
https://doaj.org/article/336b7b43de07490193e53c3207d4d1cb
Publikováno v:
Anti-Infective Agents. 17:99-104
Background: The conjugates of antibiotics are new molecules that might show new antibacterial spectrum and overcome resistance of insusceptible bacterial strains. Modification of known antibiotics like Clarithromycin with active fragments is laboriou
Eremomycin pyrrolidide: a novel semisynthetic glycopeptide with improved chemotherapeutic properties
Autor:
E. N. Bychkova, Ivan D. Treshalin, Andrey V. Dekhnich, Elena P. Mirchink, Evgenia N Olsufyeva, Maria N. Preobrazhenskaya, Mikhail G Chernobrovkin, Elena B. Isakova, Andrey E. Shchekotikhin, E. R. Pereverzeva, Roman S. Kozlov
Publikováno v:
Drug Design, Development and Therapy. 12:2875-2885
Evgenia N Olsufyeva,1 Andrey E Shchekotikhin,1,2 Elena N Bychkova,1 Eleonora R Pereverzeva,1 Ivan D Treshalin,1 Elena P Mirchink,1 Elena B Isakova,1 Mikhail G Chernobrovkin,3 Roman S Kozlov,4 Andrey V Dekhnich,4 Maria N Preobrazhenskaya1,† 1Gause I
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 452-456 (2017)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 452-456 (2017)
Clarithromycin (active against Gram positive infections) and 1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole derivatives (effective for Gram negative microbes) are the ligands of bacterial RNA. The antimicrobial activities of these benzoxaboroles linked
Autor:
Vladimir B. Tsvetkov, Dmitry N. Kaluzhny, Sergey N. Lavrenov, Anna N. Tevyashova, Nikita A. Durandin, Maria N. Preobrazhenskaya, Evgeny E. Bykov
Publikováno v:
Journal of Photochemistry and Photobiology B: Biology. 162:570-576
Triarylmethane derivatives are extensively investigated as antitumor and antibacterial drug candidates alone and as photoactivatable compounds. In the series of tris(1-alkylindol-3-yl)methylium salts (TIMs) these two activities differed depending on
Publikováno v:
Biochemistry. 55:3383-3391
Glycopeptide antibiotics inhibit cell wall biosynthesis in Gram-positive bacteria by targeting the peptidoglycan (PG) pentapeptide stem structure (l-Ala-d-iso-Gln-l-Lys-d-Ala-d-Ala). Structures of the glycopeptide complexed with a PG stem mimic have
Autor:
Michael I. Treshalin, Dominique Schols, Alexander A. Shtil, Dmitry N. Kaluzhny, Yulia L. Volodina, Anastasia A. Kalinina, Yves Pommier, Maria N. Preobrazhenskaya, Vladimir B. Tsvetkov, Lyubov G. Dezhenkova, Helen M. Treshalina, Andrey E. Shchekotikhin, Yuri N. Luzikov, Vladimir I. Romanenko, Michael H.G. Kubbutat, Victor V. Tatarskiy
Publikováno v:
Eur J Med Chem
Anthraquinones and their analogues, in particular heteroarene-fused anthracendiones, are prospective scaffolds for new compounds with improved antitumor characteristics. We herein report the use of a ‘scaffold hopping’ approach for the replacemen
Autor:
Andrey E. Shchekotikhin, Maria N. Preobrazhenskaya, Valeria A. Glazunova, Lyubov G. Dezhenkova, Chia-An Yeh, Victor V. Tatarskiy, Yi-Hui Lee, Alexander A. Shtil, Pin Ju Chueh, Yi-Ann Chen, Alexander S. Tikhomirov, Jan Balzarini
Publikováno v:
Journal of Medicinal Chemistry. 58:9522-9534
A series of new 4,11-diaminoanthra[2,3-b]furan-5,10-dione derivatives with different side chains were synthesized. Selected 2-unsubstituted derivatives 11-14 showed high antiproliferative potency on a panel of mammalian tumor cell lines including mul
Autor:
Andrei L. Okorokov, Poroikov, C. Spinnler, Vera V. Grinkevich, Elisabeth Hedström, Perdita E. Barran, Joanna Zawacka-Pankau, Aparna Vema, Natalia Issaeva, Mikhail Burmakin, Alberto Inga, Eleanor R. Dickinson, Maria N. Preobrazhenskaya, Galina Selivanova, Olga Tarasova, S. N. Lavrenov, Fawkner K, Anders Karlén, Lars Larsson, Andreotti
Given the immense significance of p53 restoration for anti-cancer therapy and that p53-activating molecules are in clinical trials, elucidation of the mechanisms of action of p53-activating molecules is of the utmost importance. Here we report a disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075188e35e1d954df35a13045e3fc84a
Autor:
Galina Selivanova, S. N. Lavrenov, C. Spinnler, Vera V. Grinkevich, Natalia Issaeva, Alberto Inga, Margareta Wilhelm, Eleanor R. Dickinson, Karin Ridderstråle, Maria N. Preobrazhenskaya, Andrei L. Okorokov, Joanna Zawacka-Pankau, Olga Tarasova, Virginia Andreotti, Mikhail Burmakin, Perdita E. Barran, Aparna Vema, Anders Karlén, Elisabeth Hedström, Vladimir Poroikov, Lars-Gunnar Larsson
Publikováno v:
SSRN Electronic Journal.
Given the immense significance of p53 restoration for anti-cancer therapy, elucidation of the mechanisms of action of p53-activating molecules is of the utmost importance. Here we report a discovery of a novel allosteric modulation of p53 by small mo