Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Maria N. Pavlova"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2023)
Background: The cGAS/STING pathway, part of the innate immune response to foreign DNA, can be activated by cell’s own DNA arising from the processing of the genome, including the degradation of nascent DNA at arrested replication forks, which can b
Externí odkaz:
https://doaj.org/article/0465a737752a4feda803ca55f2cab7c7
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105464- (2022)
Summary: D/E repeats are stretches of aspartic and/or glutamic acid residues found in over 150 human proteins. We examined genomic stability of D/E repeats and functional characteristics of D/E repeat-containing proteins vis-à-vis the proteins with
Externí odkaz:
https://doaj.org/article/4b601604b0874d27b751f83cfd289ea1
Publikováno v:
Oncogene
Rhabdomyosarcoma (RMS) is a devastating pediatric sarcoma. The survival outcomes remain poor for patients with relapsed or metastatic disease. Effective targeted therapy is lacking due to our limited knowledge of the underlying cellular and molecular
Autor:
Hongkui Zeng, Kyoji Horie, Linda Madisen, Maria N Pavlova, Galina Gragerova, Alex D Rohde, Brian A Schimpf, Yuqiong Liang, Ethan Ojala, Farah Kramer, Patricia Roth, Olga Slobodskaya, Io Dolka, Eileen A Southon, Lino Tessarollo, Karin E Bornfeldt, Alexander Gragerov, George N Pavlakis, George A Gaitanaris
Publikováno v:
PLoS Genetics, Vol 4, Iss 5, p e1000069 (2008)
Inducible and reversible regulation of gene expression is a powerful approach for uncovering gene function. We have established a general method to efficiently produce reversible and inducible gene knockout and rescue in mice. In this system, which w
Externí odkaz:
https://doaj.org/article/d20796b8c63140f2a6de21e85453e4cc
Autor:
Alexander J. Federation, Julia M. Sidorova, John Hernandez-Villanueva, Maria N. Pavlova, Michael J. MacCoss, Pavlo Lazarchuk
Publikováno v:
Mol Cell Biol
Newly synthesized histone H4 that is incorporated into chromatin during DNA replication is acetylated on lysines 5 and 12. Histone deacetylase 1 (HDAC1) and HDAC2 are responsible for reducing H4 acetylation as chromatin matures. Using CRISPR-Cas9-gen
Publikováno v:
Brain, Behavior, and Immunity. 48:244-257
Interactions between sleep and immune function are bidirectional. Although the mechanisms that govern these interactions are not fully elucidated, the pro-inflammatory cytokine, interleukin-1β (IL-1), is a known regulator of sleep and mediator of im
Autor:
Hongkui Zeng, Maria N. Pavlova, Alex Rohde, Alexander Gragerov, Brian A. Schimpf, John E. Bergmann
Publikováno v:
Molecular Endocrinology. 21:2795-2804
TRH is a neuropeptide with a variety of hormonal and neurotransmitter/neuromodulator functions. In particular, TRH has pronounced acute antidepressant effects in both humans and animals and has been implicated in the mediation of the effects of other
Autor:
Maria N. Pavlova, Emilie F. Rissman, Donald K. Clifton, Anika A. McPhie-Lalmansingh, Cristian Bodo, Alexander S. Kauffman, Alex Rohde, Jin Ho Park, John G. Hohmann, Robert A. Steiner, Michelle L. Gottsch
Publikováno v:
The Journal of Neuroscience. 27:8826-8835
GPR54 is a G-protein-coupled receptor, which binds kisspeptins and is widely expressed throughout the brain. Kisspeptin–GPR54 signaling has been implicated in the regulation of pubertal and adulthood gonadotropin-releasing hormone (GnRH) secretion,
Autor:
George A. Gaitanaris, Hui Xu, Hongkui Zeng, Hiroki Toyoda, Maria N. Pavlova, John G. Hohmann, John E. Bergmann, Rene Onrust, Alex Rohde, Brian A. Schimpf, Galina Gragerova, Ming Gao Zhao, Alexander Gragerov, Min Zhuo, Long Jun Wu
Publikováno v:
Molecular and Cellular Biology. 26:9352-9363
Neuromedin U (NMU) is a highly conserved neuropeptide with a variety of physiological functions mediated by two receptors, peripheral NMUR1 and central nervous system NMUR2. Here we report the generation and phenotypic characterization of mice defici
Autor:
Olga N. Danilevskaya, Oleg N. Voloshin, A. G. Veselkov, V. N. Dobrynin, Maria N. Pavlova, Boris P. Belotserkovskii, Maxim D. Frank-Kamenetskii
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 9:643-652
We have found, with the aid of 2-D gel electrophoresis, that double-stranded human telomeric repeat, (T2AG3)12·(C3TA2)12, being cloned within a plasmid, forms a protonated superhelically-induced structure. Experiments on chemical and enzymatic probi