Disruption of IRE1α through its kinase domain attenuates multiple myeloma

Autor: Heidi J.A. Wallweber, Diego Acosta-Alvear, Yung-Chia Ariel Chen, Maria N. Lorenzo, Jiansheng Wu, Mark Merchant, Anna Shemorry, Michael J VanWyngarden, Klara Totpal, Jonathan M. Harnoss, Alvin Gogineni, Adrien Le Thomas, Daniel W. Sherbenou, Susan Kaufman, Robby M. Weimer, Marie-Gabrielle Braun, David A. Lawrence, Weiru Wang, Kevin R Clark, Mike Reichelt, Tom De Bruyn, Steven T Laing, Min Lu, Avi Ashkenazi, David Kan, Benjamin Haley, Jing Qing, Maureen Beresini, Justin Ly, Amy Heidersbach, Ehud Segal, Wendy Sandoval, Martine Amiot, Peter Walter, Scot A. Marsters, Patricia Gomez-Bougie, Dong Lee, Joachim Rudolph

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 33
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, pp.201906999. ⟨10.1073/pnas.1906999116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, pp.201906999. ⟨10.1073/pnas.1906999116⟩

Significance Multiple myeloma (MM) is a lethal malignancy arising from plasma cells. MM cells experience endoplasmic reticulum (ER) stress due to immunoglobulin hyperproduction. The ER-resident sensor IRE1α mitigates ER stress by expanding protein-f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f25517b4217e65653d85f08aea6535f
https://escholarship.org/uc/item/4xc12533

Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination

Autor: Mercedesz Balazs, Donghong Yan, Maria N. Lorenzo, Tao Sai, Laura DeForge, Kajal Hamidzadeh, Andrew Sebrell, Yan Qu, Jin Zhaoyu, Merone Roose-Girma, Meijuan Zhou, Patrick Caplazi, Wyne P. Lee, Min Xu, Yonglian Sun, Zhonghua Lin, Kate Senger, Wei Yu Lin, Jiabing Ding, Shahram Misaghi, Allen Nguyen, Ali A. Zarrin, Søren Warming, Cary D. Austin, Vishva M. Dixit

Publikováno v: Proceedings of the National Academy of Sciences. 110:15770-15775

Preceding antibody constant regions are switch (S) regions varying in length and repeat density that are targets of activation-induced cytidine deaminase. We asked how participating S regions influence each other to orchestrate rearrangements at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba4e540cf59a6dd15e59e52d423e521
https://doi.org/10.1073/pnas.1221661110

Increased Targeting of Donor Switch Region and IgE in Sγ1-Deficient B Cells

Autor: Juan Zhang, Wyne P. Lee, Vishva M. Dixit, Kate Senger, Allen Nguyen, Donghong Yan, Maria N. Lorenzo, Yonglian Sun, Shahram Misaghi, Sherry Heldens, Ali A. Zarrin, Tao Sai, Christopher Garris, Jiansheng Wu, Laura DeForge, Andrew Sebrell, Min Xu

Publikováno v: The Journal of Immunology. 185:166-173

Ab class switch recombination involves a recombination between two repetitive DNA sequences known as switch (S) regions that vary in length, content, and density of the repeats. Abs expressed by B cells are diversified by somatic hypermutation and cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788509bc98407279ad87b0a2df615a66
https://doi.org/10.4049/jimmunol.1000515

DNA targets of AID evolutionary link between antibody somatic hypermutation and class switch recombination

Autor: Jason A, Hackney, Shahram, Misaghi, Kate, Senger, Christopher, Garris, Yonglian, Sun, Maria N, Lorenzo, Ali A, Zarrin

Publikováno v: Advances in immunology. 101

As part of the adaptive immune response, B cells alter their functional immunoglobulin (Ig) receptor genes through somatic hypermutation (SHM) and/or class switch recombination (CSR) via processes that are initiated by activation induced cytidine dea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9dd1c35bb9bcdfa980823bc0b16bcc0b
https://pubmed.ncbi.nlm.nih.gov/19231595

Oncogenic ERBB3 Mutations in Human Cancers

Autor: Frederic J. de Sauvage, Steffen Durinck, Mark X. Sliwkowski, Kyle A. Edgar, Howard M. Stern, Chaitali Parikh, Zhengyan Kan, Krista K. Bowman, Rolf-Peter Scholz, Somasekar Seshagiri, Jeremy Stinson, Wenlin Yuan, Vasantharajan Janakiraman, Maria N. Lorenzo, Subhra Chaudhuri, Ron Firestein, Jiansheng Wu, Michelle Mak, Emily Chan, Mark Merchant, Charles Eigenbrot, Bijay S. Jaiswal, Zora Modrusan, Joseph Guillory, Brock A. Peters, Kanan Pujara, Eric Stawiski, Hong Li, Gabriele Schaefer, Krishnaraj Rajalingam, Noelyn M. Kljavin

Publikováno v: Cancer Cell. (4):543-544

SummaryThe human epidermal growth factor receptor (HER) family of tyrosine kinases is deregulated in multiple cancers either through amplification, overexpression, or mutation. ERBB3/HER3, the only member with an impaired kinase domain, although ampl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5201da8376aa97bd311be6169033087