Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Maria Mysliwski"'
Autor:
Nirmalya Saha, James Ropa, Lili Chen, Hsiangyu Hu, Maria Mysliwski, Ann Friedman, Ivan Maillard, Andrew G. Muntean
Publikováno v:
Stem Cell Reports, Vol 12, Iss 5, Pp 1069-1083 (2019)
Summary: The Polymerase Associated Factor 1 complex (PAF1c) functions at the interface of epigenetics and gene transcription. The PAF1c is required for MLL fusion-driven acute myeloid leukemia (AML) through direct regulation of pro-leukemic target ge
Externí odkaz:
https://doaj.org/article/c347014f607e4d5dbfe85c3398f6fdef
Autor:
Ann Friedman, Andrew G. Muntean, Nirmalya Saha, Hsiangyu Hu, Maria Mysliwski, Ivan Maillard, James Ropa, Lili Chen
Publikováno v:
Stem Cell Reports, Vol 12, Iss 5, Pp 1069-1083 (2019)
Summary: The Polymerase Associated Factor 1 complex (PAF1c) functions at the interface of epigenetics and gene transcription. The PAF1c is required for MLL fusion-driven acute myeloid leukemia (AML) through direct regulation of pro-leukemic target ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a49c1c608b61c3c5d3c166cd182440
http://www.sciencedirect.com/science/article/pii/S2213671119300955
http://www.sciencedirect.com/science/article/pii/S2213671119300955
Autor:
Jolanta Grembecka, James Ropa, Andrew G. Muntean, Wei Chen, Lili Chen, Tomasz Cierpicki, Justin Serio, Hongzhi Miao, Maria Mysliwski, Nirmalya Saha, Jingya Wang
Publikováno v:
Oncogene
Acute myeloid leukemia (AML) is a disease associated with epigenetic dysregulation. 11q23 translocations involving the H3K4 methyltransferase MLL1 (KMT2A) generate oncogenic fusion proteins with deregulated transcriptional potential. The Polymerase A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5734a741b34ca37e37ee71c40abdedaa
https://doi.org/10.1038/onc.2017.337
https://doi.org/10.1038/onc.2017.337
Autor:
Lili Chen, Andrew G. Muntean, Wei Chen, Maria Mysliwski, Ari Melnick, Ross L. Levine, James Ropa, Justin Serio, Zaneta Nikolovska-Coleska, Rebecca J. Chan, Jay P. Patel, Fardokht A. Abulwerdi, Martin S. Tallman, Omar Abdel-Wahab, Elisabeth Paietta
Publikováno v:
Leukemia
PTPN11 encodes the Shp2 non-receptor protein-tyrosine phosphatase implicated in several signaling pathways. Activating mutations in Shp2 are commonly associated with juvenile myelomonocytic leukemia but are not as well defined in other neoplasms. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6fe838d33d833868eb20423488efea5
http://europepmc.org/articles/PMC4456293
http://europepmc.org/articles/PMC4456293
Autor:
Ann Friedman, James Ropa, Nirmalya Saha, Maria Mysliwski, Ivan Maillard, Hsiangyu Hu, Andrew G. Muntean, Lili Chen
Publikováno v:
Blood. 132:1280-1280
The Polymerase Associated Factor 1 complex (PAF1c) functions at the interface of epigenetics and gene transcription. The PAF1c is a multi-protein complex composed of Paf1, Cdc73, Leo1, Ctr9, Rtf1 and WDR61, which have all been shown to play a role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0f0bf9ca6c1bb648d24e68e15ec73ed
https://doi.org/10.1182/blood-2018-99-118703
https://doi.org/10.1182/blood-2018-99-118703
Autor:
James Ropa, Maria Mysliwski, Jingya Wang, Wei Chen, Lili Chen, Justin Serio, Andrew G. Muntean
Publikováno v:
Blood. 128:3914-3914
Acute myeloid leukemias have been linked with dysregulated epigenetic landscapes sometimes attributed to altered functions of epigenetic regulators. The Polymerase-Associated Factor complex (PAFc) is an epigenetic regulator involved in transcriptiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8b8336e27be9377b04cae30359280df
https://doi.org/10.1182/blood.v128.22.3914.3914
https://doi.org/10.1182/blood.v128.22.3914.3914
Autor:
Lili Chen, Ross L. Levine, Zaneta Nikolovska-Coleska, Justin Serio, Wei Chen, Jay P. Patel, Fardokht A. Abulwerdi, Andrew G. Muntean, Martin S. Tallman, Rebecca J. Chan, James Ropa, Elisabeth Paietta, Ari Melnick, Omar Abdel-Wahab, Maria Mysliwski
Publikováno v:
Blood. 124:3565-3565
Shp2 is a non-receptor protein-tyrosine phosphatase encoded by PTPN11 and implicated in the Ras, JAK-STAT and PI3K pathways. Activating mutations in Shp2 are found in patients with developmental disorders such as Noonan and LEOPARD syndrome, as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b002f34b8ac03ad451e44b5241f425be
https://doi.org/10.1182/blood.v124.21.3565.3565
https://doi.org/10.1182/blood.v124.21.3565.3565