Depletion of Human Papilloma Virus E6- and E7-Oncoprotein-Specific T-Cell Responses in Women Living With HIV

Autor: Wilbert Mbuya, Kathrin Held, Ruby D. Mcharo, Antelmo Haule, Jacklina Mhizde, Jonathan Mnkai, Anifrid Mahenge, Maria Mwakatima, Margareth Sembo, Wolfram Mwalongo, Peter Agrea, Michael Hoelscher, Leonard Maboko, Elmar Saathoff, Otto Geisenberger, France Rwegoshora, Liset Torres, Richard A. Koup, Arne Kroidl, Mkunde Chachage, Christof Geldmacher

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

BackgroundCervical cancer - caused by persistent High Risk Human Papilloma Virus (HR HPV) infections - is the second most common cancer affecting women globally. HIV infection increases the risk for HPV persistence, associated disease progression and

Externí odkaz: https://doaj.org/article/2f9c7e15a0254526b38b90ee19cae850

Depletion and activation of mucosal CD4 T cells in HIV infected women with HPV-associated lesions of the cervix uteri

Autor: Jacklina Mhizde, Nhamo Chiwerengo, Wolfram Mwalongo, Christof Geldmacher, Jonathan Mnkai, Anifrid Mahenge, Mkunde Chachage, Wilbert Mbuya, Tessa Lennemann, Kathrin Held, Arne Kroidl, Elmar Saathoff, Liset Torres, Ruby Mcharo, Maria Mwakatima, Michael Hölscher

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0240154 (2020)

BackgroundThe burden of HPV-associated premalignant and malignant cervical lesions remains high in HIV+ women even under ART treatment. In order to identify possible underlying pathophysiologic mechanisms, we studied activation and HIV co-receptor ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443fd0dbf06aa6a7286d8b3c0d1e28b3
https://pubmed.ncbi.nlm.nih.gov/33007050

Preferential targeting of conserved Gag regions after vaccination with a heterologous DNA prime Modified Vaccinia Ankara boost HIV vaccine regime

Autor: Said Aboud, Merlin L. Robb, Caroline Nilsson, Bahati Kaluwa, Cornelia Lueer, Gunnel Biberfeld, JR Currier, L. Sudi, Eligius Lyamuya, Britta Wahren, Christof Geldmacher, Antelmo Haule, Leonard Maboko, Lilli Podola, Sheena McCormack, P. Mann, Sarah Joseph, Eric Sandström, Michael Hoelscher, Marco Missanga, Asli Bauer, Muhammad Bakari, Maria Mwakatima, Arne Kroidl

Publikováno v: Retrovirology, Vol 9, Iss Suppl 2, p P330 (2012)
Retrovirology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f03e89a0a389f6ac4051e1ff7be162

Depletion and activation of mucosal CD4 T cells in HIV infected women with HPV-associated lesions of the cervix uteri.

Autor: Mbuya, Wilbert¹ (AUTHOR), Mcharo, Ruby^1,2 (AUTHOR), Mhizde, Jacklina¹ (AUTHOR), Mnkai, Jonathan¹ (AUTHOR), Mahenge, Anifrid¹ (AUTHOR), Mwakatima, Maria¹ (AUTHOR), Mwalongo, Wolfram¹ (AUTHOR), Chiwerengo, Nhamo¹ (AUTHOR), Hölscher, Michael^3,4 (AUTHOR), Lennemann, Tessa^1,3 (AUTHOR), Saathoff, Elmar^3,4 (AUTHOR), Rwegoshora, France⁵ (AUTHOR), Torres, Liset⁵ (AUTHOR), Kroidl, Arne^3,4 (AUTHOR), Geldmacher, Christof^3,4 (AUTHOR), Held, Kathrin^3,4 (AUTHOR), Chachage, Mkunde^1,2,3 (AUTHOR) mchachage@nimr-mmrc.org

Publikováno v: PLoS ONE. 10/2/2020, Vol. 15 Issue 10, p1-17. 17p.