Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Maria Monica Castellanos"'
Autor:
Maria Monica Castellanos, Hervé Gressard, Xiangming Li, Claudia Magagnoli, Alessio Moriconi, Daniela Stranges, Laurent Strodiot, Monica Tello Soto, Magdalena Zwierzyna, Cristiana Campa
Publikováno v:
Vaccines, Vol 11, Iss 7, p 1153 (2023)
This review reports on an overview of key enablers of acceleration/pandemic and preparedness, covering CMC strategies as well as technical innovations in vaccine development. Considerations are shared on implementation hurdles and opportunities to dr
Externí odkaz:
https://doaj.org/article/14fff212f9a04752adaf182a760c9ad6
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 15, Iss , Pp 117-130 (2017)
In order to increase shelf life and minimize aggregation during storage, many biotherapeutic drugs are formulated and stored as either frozen solutions or lyophilized powders. However, characterizing amorphous solids can be challenging with the commo
Externí odkaz:
https://doaj.org/article/e8887b3d953346049a7548d6883398e8
Autor:
Maria Monica Castellanos, James A. Snyder, Melody Lee, Srinivas Chakravarthy, Nicholas J. Clark, Arnold McAuley, Joseph E. Curtis
Publikováno v:
Antibodies, Vol 6, Iss 4, p 25 (2017)
The determination of monoclonal antibody interactions with protein antigens in solution can lead to important insights guiding physical characterization and molecular engineering of therapeutic targets. We used small-angle scattering (SAS) combined w
Externí odkaz:
https://doaj.org/article/93de80c768d84c6e9a798fd516eba994
Autor:
Emanuele Tomba, Moritz von Stosch, Antonio Gaetano Cardillo, Bernadette Scutellà, Benoit Desailly, Rui M C Portela, Marco Mariti, Christos Varsakelis, Sandrine Dessoy, Maria Monica Castellanos
Publikováno v:
Trends in Biotechnology. 39:1120-1130
Chemical, manufacturing, and control development timelines occupy a significant part of vaccine end-to-end development. In the on-going race for accelerating timelines, in silico process development constitutes a viable strategy that can be achieved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a29c08b0c93f37e42e709cd0ef0c44
https://doi.org/10.1016/j.tibtech.2021.02.004
https://doi.org/10.1016/j.tibtech.2021.02.004
Publikováno v:
Molecular Pharmaceutics. 16:4319-4338
Excipients are substances that are added to therapeutic products to improve stability, bioavailability, and manufacturability. Undesirable protein-protein interactions (PPI) can lead to self-association and/or high solution viscosity in concentrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c71c4a7d4165ab795da8166a9fbc98
https://doi.org/10.1021/acs.molpharmaceut.9b00687
https://doi.org/10.1021/acs.molpharmaceut.9b00687
Autor:
Amy Y. Xu, Khaleda C. Rinee, Carrie Stemple, Maria Monica Castellanos, Kunal Bakshi, Susan Krueger, Joseph E. Curtis
Publikováno v:
Colloids and Surfaces A: Physicochemical and Engineering Aspects. 648:129285
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d778e69720d73e8d222e8a3b3f41bcc0
https://doi.org/10.1016/j.colsurfa.2022.129285
https://doi.org/10.1016/j.colsurfa.2022.129285
Publikováno v:
Molecular pharmaceutics. 17(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ad59f444d81f137bc3dfe09c5d73f0
https://pubmed.ncbi.nlm.nih.gov/31487466
https://pubmed.ncbi.nlm.nih.gov/31487466
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 15, Iss, Pp 117-130 (2017)
Computational and Structural Biotechnology Journal, Vol 15, Iss, Pp 117-130 (2017)
In order to increase shelf life and minimize aggregation during storage, many biotherapeutic drugs are formulated and stored as either frozen solutions or lyophilized powders. However, characterizing amorphous solids can be challenging with the commo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d036d27aa103f527996379e0446342ba
Autor:
Gary G. Adams, Stephen E. Harding, Prakash Manikwar, Tabot M. D. Besong, Maria Monica Castellanos, Prasad Sarangapani, Justin Weaver, Jai A. Pathak, Steven M. Bishop, Arun Parupudi
Publikováno v:
Journal of Pharmaceutical Sciences. 105:3496-3506
The role of antibody structure (conformation) in solution rheology is probed. It is demonstrated here that pH-dependent changes in the tertiary structure of 2 mAb solutions lead to viscoelasticity and not merely a shear viscosity (η) increase. Stead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf04115feca0285111bd8f96a023430
https://doi.org/10.1016/j.xphs.2016.08.020
https://doi.org/10.1016/j.xphs.2016.08.020
Publikováno v:
Analytical and bioanalytical chemistry. 410(8)
Both conformational and colloidal stability of therapeutic proteins must be closely monitored and thoroughly characterized to assess the long-term viability of drug products. We characterized the IgG1 NISTmAb reference material in its histidine formu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f55f615aef0dc960586791c4dd5f4b0
https://pubmed.ncbi.nlm.nih.gov/29423596
https://pubmed.ncbi.nlm.nih.gov/29423596