Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Maria Merezhko"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
The progressive accumulation and spread of misfolded tau protein in the nervous system is the hallmark of tauopathies, progressive neurodegenerative diseases with only symptomatic treatments available. A growing body of evidence suggests that spreadi
Externí odkaz:
https://doaj.org/article/9baa0048fba840afa133bd0cf11844fa
Autor:
Maria Merezhko, Cecilia A. Brunello, Xu Yan, Helena Vihinen, Eija Jokitalo, Riikka-Liisa Uronen, Henri J. Huttunen
Publikováno v:
Cell Reports, Vol 25, Iss 8, Pp 2027-2035.e4 (2018)
Summary: Tauopathies are characterized by cerebral accumulation of Tau protein aggregates that appear to spread throughout the brain via a cell-to-cell transmission process that includes secretion and uptake of pathological Tau, followed by templated
Externí odkaz:
https://doaj.org/article/edd5d11efc994e8eb980687d1c73f433
Autor:
Maria Merezhko, Pranuthi Muggalla, Niko-Petteri Nykänen, Xu Yan, Prasanna Sakha, Henri J Huttunen
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98619 (2014)
Amyloid-β precursor protein (APP) plays a central role in pathogenesis of Alzheimer's disease. APP has a short half-life and undergoes complex proteolytic processing that is highly responsive to various stimuli such as changes in cellular lipid or e
Externí odkaz:
https://doaj.org/article/3ef70c38ce114ebdb4ad62b2be0d6b4a
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
The progressive accumulation and spread of misfolded tau protein in the nervous system is the hallmark of tauopathies, progressive neurodegenerative diseases with only symptomatic treatments available. A growing body of evidence suggests that spreadi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf69483d7d15305c844df5e0d5d19b32
https://doi.org/10.3389/fnmol.2020.569818
https://doi.org/10.3389/fnmol.2020.569818
Publikováno v:
Bioscience Reports
The plasma membrane consists of a variety of discrete domains differing from the surrounding membrane in composition and properties. Selective partitioning of protein to these microdomains is essential for membrane functioning and integrity. Studying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71aa0a8930eac25428ec92924c29584
https://doi.org/10.1042/bsr20191290
https://doi.org/10.1042/bsr20191290
Publikováno v:
Cellular and Molecular Life Sciences
Accumulation of misfolded and aggregated forms of tau protein in the brain is a neuropathological hallmark of tauopathies, such as Alzheimer’s disease and frontotemporal lobar degeneration. Tau aggregates have the ability to transfer from one cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4ce67a0ce6295316f1ba1c8b034969
https://pubmed.ncbi.nlm.nih.gov/31667556
https://pubmed.ncbi.nlm.nih.gov/31667556
Autor:
Cecilia A. Brunello, Riikka-Liisa Uronen, Eija Jokitalo, Xu Yan, Helena Vihinen, Maria Merezhko, Henri J. Huttunen
Publikováno v:
SSRN Electronic Journal.
Cerebral accumulation of Tau protein aggregates, in the form of neurofibrillary tangles, is a pathological hallmark of numerous neurodegenerative disorders including Alzheimer's disease. In these tauopathies, Tau forms inclusions that spread througho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c82363ee7bf92b229c9ffe750bbf4d9
https://doi.org/10.2139/ssrn.3188432
https://doi.org/10.2139/ssrn.3188432
Autor:
Maria Merezhko, Xu Yan, Niko-Petteri Nykänen, Pranuthi Muggalla, Prasanna Sakha, Henri J. Huttunen
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98619 (2014)
PLoS ONE
PLoS ONE
Amyloid-β precursor protein (APP) plays a central role in pathogenesis of Alzheimer's disease. APP has a short half-life and undergoes complex proteolytic processing that is highly responsive to various stimuli such as changes in cellular lipid or e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7365b2616b47a193e87b8eea09aa20
http://hdl.handle.net/10138/160703
http://hdl.handle.net/10138/160703
Autor:
Maria Merezhko, Cecilia Brunello, Anja Helena Vihinen, Eija Sofia Jokitalo, Riikka-Liisa Uronen-Mattila, Henri Juhani Huttunen
Publikováno v:
University of Helsinki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::04d5edcffd9fe882a053d2c315bfc003
https://researchportal.helsinki.fi/en/publications/f80ed437-0628-4779-8234-1e3a5132845e
https://researchportal.helsinki.fi/en/publications/f80ed437-0628-4779-8234-1e3a5132845e