Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Maria Menichincheri"'
Autor:
Francesco Casuscelli, Elena Ardini, Nilla Avanzi, Alessandra Badari, Elena Casale, Teresa Disingrini, Daniele Donati, Antonella Ermoli, Eduard R. Felder, Arturo Galvani, Antonella Isacchi, Maria Menichincheri, Marisa Montemartini, Christian Orrenius, Claudia Piutti, Barbara Salom, Gianluca Papeo
Publikováno v:
Chirality. 34:1437-1452
We previously demonstrated that natural product-inspired 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ones derivatives delivered potent and selective PIM kinases inhibitors however with non-optimal ADME/PK properties and modest oral bioavailability. Herein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b668b1e8b6a6904c54bd11cd826e99
https://doi.org/10.1002/chir.23501
https://doi.org/10.1002/chir.23501
Autor:
Arturo Galvani, Paola Magnaghi, Enrico Pesenti, Antonella Isacchi, Daniele Donati, Eduard Felder, Gang Li, Jean-Michel Vernier, Jason Harris, Ge Wei, David Anderson, Luca Mologni, Tiziano Bandiera, Paolo Orsini, Daniele Casero, Maria Beatrice Saccardo, Nadia Amboldi, Nilla Avanzi, Anna Degrassi, Gemma Texido, Marina Ciomei, Dario Ballinari, Romana Pulci, Cristina De Ponti, Roberta Bosotti, Patrizia Banfi, Maria Menichincheri, Elena Ardini
Supplementary experimental procedures are described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e7349af36e6ac21496c6964180ab8f
https://doi.org/10.1158/1535-7163.22508037
https://doi.org/10.1158/1535-7163.22508037
Autor:
Arturo Galvani, Paola Magnaghi, Enrico Pesenti, Antonella Isacchi, Daniele Donati, Eduard Felder, Gang Li, Jean-Michel Vernier, Jason Harris, Ge Wei, David Anderson, Luca Mologni, Tiziano Bandiera, Paolo Orsini, Daniele Casero, Maria Beatrice Saccardo, Nadia Amboldi, Nilla Avanzi, Anna Degrassi, Gemma Texido, Marina Ciomei, Dario Ballinari, Romana Pulci, Cristina De Ponti, Roberta Bosotti, Patrizia Banfi, Maria Menichincheri, Elena Ardini
Supplementary Figure 1. Efficacy of entrectinib on KM12 xenograft model using the scheduling 4 days on/ 3 days off. Supplementary Figure 2. Mechanism of action of entrectinib compared to crizotinib in ALK-dependent Ba/F3 cells. Supplementary Figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f11ccf8c2eee09b004c4cb5d12e7089
https://doi.org/10.1158/1535-7163.22508040
https://doi.org/10.1158/1535-7163.22508040
Emotional dysregulation, temperament and lifetime suicidal ideation among youths with mood disorders
Autor:
Lorenzo Moccia, Gabriele Sani, Giulia Fredda, Luigi Janiri, Georgios D. Kotzalidis, Delfina Janiri, Eliana Conte, Renato Maria Menichincheri, Daniela Chieffo, Andrea Balbi, Laura Palumbo
Publikováno v:
Journal of Personalized Medicine
Journal of Personalized Medicine, Vol 11, Iss 865, p 865 (2021)
Volume 11
Issue 9
Journal of Personalized Medicine, Vol 11, Iss 865, p 865 (2021)
Volume 11
Issue 9
Background: Psychopathological dimensions contributing to suicidal ideation in young age are poorly understood. We aimed to investigate the involvement of emotional dysregulation and temperament in suicide risk in a sample of accurately selected youn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb32ac6cdf27281aa510d38a818c055c
http://hdl.handle.net/10807/201349
http://hdl.handle.net/10807/201349
Autor:
Christian Orrenius, Antonio Lomolino, Claudia Perrera, Paola Gnocchi, Nilla Avanzi, Elena Casale, Francesca Quartieri, Marcella Nesi, Arturo Galvani, Marina Fasolini, Emiliana Corti, Daniele Donati, Federico Riccardi-Sirtori, Maria Laura Giorgini, Stefania Re Depaolini, Enea Salsi, Eduard R. Felder, Antonella Isacchi, Daniela Borghi, Ulisse Cucchi, Maria Menichincheri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 51:128310
In this article we describe the identification of unprecedented ATP-competitive ChoKα inhibitors starting from initial hit NMS-P830 that binds to ChoKα in an ATP concentration-dependent manner. This result is confirmed by the co-crystal structure o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28088bfd6a53b4154d2a1addbdf62e8
https://doi.org/10.1016/j.bmcl.2021.128310
https://doi.org/10.1016/j.bmcl.2021.128310
Autor:
Daniele Donati, Andrea Lombardi Borgia, Ettore Perrone, Lucio Ceriani, Chiara Marchionni, Paolo Orsini, Marcella Nesi, Luisa Rusconi, Paola Magnaghi, Marina Fasolini, Nilla Avanzi, G. Canevari, Arturo Galvani, Maristella Colombo, Patrizia Banfi, Elena Ardini, Laura Buffa, Antonella Isacchi, Christian Orrenius, Roberto Bossi, Maria Beatrice Saccardo, Ermes Vanotti, Claudio Fiorelli, Francesco Fiorentini, Maria Menichincheri, Achille Panzeri, Luca Corti, Enrico Pesenti, Eduard R. Felder
Publikováno v:
Journal of Medicinal Chemistry. 59:3392-3408
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase responsible for the development of different tumor types. Despite the remarkable clinical activity of crizotinib (Xalkori), the first ALK inhibitor approved in 2011, the emergence of resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc806429f7d1f3155f365de5d16bf20
https://doi.org/10.1021/acs.jmedchem.6b00064
https://doi.org/10.1021/acs.jmedchem.6b00064
Publikováno v:
Cancer Letters. 299:81-94
The Anaplastic Lymphoma Kinase (ALK) is a receptor tyrosine kinase first identified as the product of a gene rearrangement in Anaplastic Large Cell Lymphoma. ALK has subsequently been found to be rearranged, mutated, or amplified in a further series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d4593218909763050845565e4bfd94
https://doi.org/10.1016/j.canlet.2010.09.001
https://doi.org/10.1016/j.canlet.2010.09.001
Autor:
Elena Ardini, Dario Ballinari, Eduard R. Felder, Alessandra Cirla, Paolo Polucci, Arturo Galvani, Patrizia Banfi, Antonella Isacchi, Ilaria Motto, Daniele Donati, Cinzia Cristiani, Nilla Avanzi, Andrea Lombardi Borgia, Maria Menichincheri, Matteo D'anello, Marina Ciomei
Publikováno v:
Cancer Research. 78:4785-4785
RET chromosomal rearrangements initially identified in a subset of papillary thyroid cancers, as well as gain-of-function point mutations present in ca. 70% of medullary thyroid carcinomas, are well established as oncogenic events that induce constit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a6daf68179996952cd4c74885a7b924
https://doi.org/10.1158/1538-7445.am2018-4785
https://doi.org/10.1158/1538-7445.am2018-4785
Autor:
Elena Ardini, Gianpaolo Fogliatto, A.L. Borgia, M. Nesi, T. Bandiera, Luisa Rusconi, Maria Menichincheri, Paola Magnaghi, M.B. Saccardo, R.T. Bossi, Paolo Orsini, N. Avanzi, J.A. Bertrand
Publikováno v:
Biochemistry. 49:6813-6825
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase involved in the development of several human cancers and, as a result, is a recognized target for the development of small-molecule inhibitors for the treatment of ALK-positive malignanci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96252bf8912f9caa864c455409930a7c
https://doi.org/10.1021/bi1005514
https://doi.org/10.1021/bi1005514
Autor:
Ermes Vanotti, Paola Vianello, Marcella Nesi, Marina Caldarelli, Marco Tato, Teresa Disingrini, Maria Menichincheri
Publikováno v:
Tetrahedron. 65:10418-10423
The regioselective synthesis of halogenated aminopyrimidinyl-pyrroles as useful scaffolds for the preparation of diversified selective kinase inhibitors is described. The chemistry is simple and mostly based on the use of N-halosuccinimides under mil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46ba3723cc91b09794d10e1716a3fbbe
https://doi.org/10.1016/j.tet.2009.10.030
https://doi.org/10.1016/j.tet.2009.10.030