Copper deficiency leads to anemia, duodenal hypoxia, upregulation of HIF-2α and altered expression of iron absorption genes in mice.

Autor: Pavle Matak, Sara Zumerle, Maria Mastrogiannaki, Souleiman El Balkhi, Stephanie Delga, Jacques R R Mathieu, François Canonne-Hergaux, Joel Poupon, Paul A Sharp, Sophie Vaulont, Carole Peyssonnaux

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e59538 (2013)

Iron and copper are essential trace metals, actively absorbed from the proximal gut in a regulated fashion. Depletion of either metal can lead to anemia. In the gut, copper deficiency can affect iron absorption through modulating the activity of heph

Externí odkaz: https://doaj.org/article/a5f824f1a9bf407e9df217544a611f2d

HIF-2α, but not HIF-1α, promotes iron absorption in mice

Autor: M. Celeste Simon, Pavle Matak, Maria Mastrogiannaki, Brian Keith, Carole Peyssonnaux, Sophie Vaulont

Publikováno v: Journal of Clinical Investigation. 119:1159-1166

HIF transcription factors (HIF-1 and HIF-2) are central mediators of cellular adaptation to hypoxia. Because the resting partial pressure of oxygen is low in the intestinal lumen, epithelial cells are believed to be mildly hypoxic. Having recently es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe58550282adbdd1bc5a64b610740ed6
https://doi.org/10.1172/jci38499

Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages

Autor: Beate M, Lichtenberger, Maria, Mastrogiannaki, Fiona M, Watt

Publikováno v: Nature Communications

Sustained epidermal Wnt/β-catenin signalling expands the stem cell compartment and induces ectopic hair follicles (EFs). This is accompanied by extensive fibroblast proliferation and extracellular matrix (ECM) remodelling in the underlying dermis. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02a358378b4d1b0ff8c5675a5b9439af
https://pubmed.ncbi.nlm.nih.gov/26837596

The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions

Autor: Maria Mastrogiannaki, Pavle Matak, Carole Peyssonnaux

Publikováno v: Blood
Blood, American Society of Hematology, 2013, 122 (6), pp.885-92. ⟨10.1182/blood-2012-11-427765⟩
Blood, 2013, 122 (6), pp.885-92. ⟨10.1182/blood-2012-11-427765⟩
Blood, American Society of Hematology, 2013, 122 (6), pp.885-92. 〈10.1182/blood-2012-11-427765〉

Although earlier, seminal studies demonstrated that the gut per se has the intrinsic ability to regulate the rates of iron absorption, the spotlight in the past decade has been placed on the systemic regulation of iron homeostasis by the hepatic horm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe33817d59afb9972d29967f2f29b7e
https://www.hal.inserm.fr/inserm-01068507/file/885.full.pdf

Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis

Autor: Stéphanie Delga, Maria Mastrogiannaki, Carole Peyssonnaux, Pavle Matak, Jacques Mathieu, Patrick Mayeux, Sophie Vaulont

Publikováno v: Haematologica

Background Iron metabolism, regulated by the iron hormone hepcidin, and oxygen homeostasis, dependent on hypoxia-inducible factors, are strongly interconnected. We previously reported that in mice in which both liver hypoxia-inducible factors-1 and -

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fd6dca44db7a2d45004e1225768726
https://pubmed.ncbi.nlm.nih.gov/22207682