Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Maria Manfredi-Lozano"'
Hypothalamic miR-30 regulates puberty onset via repression of the puberty-suppressing factor, Mkrn3.
Autor:
Violeta Heras, Susana Sangiao-Alvarellos, Maria Manfredi-Lozano, María J Sanchez-Tapia, Francisco Ruiz-Pino, Juan Roa, Maribel Lara-Chica, Rosario Morrugares-Carmona, Nathalie Jouy, Ana P Abreu, Vincent Prevot, Denise Belsham, Maria J Vazquez, Marco A Calzado, Leonor Pinilla, Francisco Gaytan, Ana C Latronico, Ursula B Kaiser, Juan M Castellano, Manuel Tena-Sempere
Publikováno v:
PLoS Biology, Vol 17, Iss 11, p e3000532 (2019)
Mkrn3, the maternally imprinted gene encoding the makorin RING-finger protein-3, has recently emerged as putative pubertal repressor, as evidenced by central precocity caused by MKRN3 mutations in humans; yet, the molecular underpinnings of this key
Externí odkaz:
https://doaj.org/article/ef93c7a3add44a31bc7144e1863b1fe4
Defining a novel leptin–melanocortin–kisspeptin pathway involved in the metabolic control of puberty
Autor:
Maria Manfredi-Lozano, Juan Roa, Francisco Ruiz-Pino, Richard Piet, David Garcia-Galiano, Rafael Pineda, Aurora Zamora, Silvia Leon, Miguel A. Sanchez-Garrido, Antonio Romero-Ruiz, Carlos Dieguez, Maria Jesus Vazquez, Allan E. Herbison, Leonor Pinilla, Manuel Tena-Sempere
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 844-857 (2016)
Objective: Puberty is a key developmental phenomenon highly sensitive to metabolic modulation. Worrying trends of changes in the timing of puberty have been reported in humans. These might be linked to the escalating prevalence of childhood obesity a
Externí odkaz:
https://doaj.org/article/5cc37d0b03aa4825aef4cba9b188774d
Autor:
Juergen Siepmann, Delphine Franssen, François P. Pralong, Tori Lhomme, Cecile Allet, Anne-Simone Parent, Adrian Coutteau-Robles, Manuel Tena-Sempere, Gabriel Corfas, Danièle Mazur, S. Rasika, Sarah Geller, Anne Loyens, Maria Manfredi-Lozano, Ariane Sharif, Giuliana Pellegrino, Virginia Delli, Vincent Prevot, Marion Martin, Sergio R. Ojeda, Philippe Ciofi, Virginie Mansuy
Publikováno v:
Nature Neuroscience. 24:1660-1672
Neurons that produce gonadotropin-releasing hormone (GnRH), which control fertility, complete their nose-to-brain migration by birth. However, their function depends on integration within a complex neuroglial network during postnatal development. Her
Autor:
Giuliana, Pellegrino, Marion, Martin, Cécile, Allet, Tori, Lhomme, Sarah, Geller, Delphine, Franssen, Virginie, Mansuy, Maria, Manfredi-Lozano, Adrian, Coutteau-Robles, Virginia, Delli, S, Rasika, Danièle, Mazur, Anne, Loyens, Manuel, Tena-Sempere, Juergen, Siepmann, François P, Pralong, Philippe, Ciofi, Gabriel, Corfas, Anne-Simone, Parent, Sergio R, Ojeda, Ariane, Sharif, Vincent, Prevot
Publikováno v:
Yearbook of Paediatric Endocrinology.
Neurons that produce gonadotropin-releasing hormone (GnRH), which control fertility, complete their nose-to-brain migration by birth. However, their function depends on integration within a complex neuroglial network during postnatal development. Her
Autor:
Maria Manfredi-Lozano, Valerie Leysen, Michela Adamo, Isabel Paiva, Renaud Rovera, Jean-Michel Pignat, Fatima Ezzahra Timzoura, Michael Candlish, Sabiha Eddarkaoui, Samuel A. Malone, Mauro S. B. Silva, Sara Trova, Monica Imbernon, Laurine Decoster, Ludovica Cotellessa, Manuel Tena-Sempere, Marc Claret, Ariane Paoloni-Giacobino, Damien Plassard, Emmanuelle Paccou, Nathalie Vionnet, James Acierno, Aleksandra Maleska Maceski, Antoine Lutti, Frank Pfrieger, S. Rasika, Federico Santoni, Ulrich Boehm, Philippe Ciofi, Luc Buée, Nasser Haddjeri, Anne-Laurence Boutillier, Jens Kuhle, Andrea Messina, Bogdan Draganski, Paolo Giacobini, Nelly Pitteloud, Vincent Prevot
Publikováno v:
Science
Science, 2022, 377 (6610), ⟨10.1126/science.abq4515⟩
Science, 2022, 377 (6610), pp.eabq4515. ⟨10.1126/science.abq4515⟩
Science, 2022, 377 (6610), ⟨10.1126/science.abq4515⟩
Science, 2022, 377 (6610), pp.eabq4515. ⟨10.1126/science.abq4515⟩
International audience; At the present time, no viable treatment exists for cognitive and olfactory deficits in Down syndrome (DS). We show in a DS model (Ts65Dn mice) that these progressive nonreproductive neurological symptoms closely parallel a po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abe0765102c92260fe988bb0fe38640
https://hdl.handle.net/10668/20028
https://hdl.handle.net/10668/20028
Publikováno v:
Frontiers in Neuroendocrinology. 48:37-49
Albeit essential for perpetuation of species, reproduction is an energy-demanding function that can be adjusted to body metabolic status. Reproductive maturation and function can be suppressed in conditions of energy deficit, but can be altered also
Autor:
Silvia Leon, Carlos Dieguez, Alexia Barroso, María Jesús Vázquez, Maria Manfredi-Lozano, Daniel Beiroa, Rubén Nogueiras, Leonor Pinilla, Juan Roa, Violeta Heras, Manuel Tena-Sempere, Inmaculada Velasco, Antonio Romero-Ruiz, Miguel A. Sánchez-Garrido, Francisco Ruiz-Pino
Publikováno v:
Metabolism. 87:87-97
Background RF-amide-related peptide-3 (RFRP-3), the mammalian ortholog of gonadotropin-inhibiting hormone, operates as inhibitory signal for the reproductive axis. Recently, RFRP-3 has been also suggested to stimulate feeding, and therefore might con
Autor:
Maria Manfredi-Lozano, Daniela Fernandois, Miguel A. Sánchez-Garrido, Inmaculada Velasco, Violeta Heras, Juan Carlos Roa, Juan M. Castellano, Alexia Barroso, Leonor Pinilla, María Jesús Vázquez, Francisco Ruiz-Pino, Manuel Tena-Sempere
Publikováno v:
Endocrinology. 159:1005-1018
Obesity and its comorbidities are reaching epidemic proportions worldwide. Maternal obesity is known to predispose the offspring to metabolic disorders, independently of genetic inheritance. This intergenerational transmission has also been suggested
Autor:
Leonor Pinilla, Violeta Heras, Maria Manfredi-Lozano, Denise D. Belsham, Rosario Morrugares-Carmona, Juan M. Castellano, María J. Sanchez-Tapia, Marco A. Calzado, Manuel Tena-Sempere, Maribel Lara-Chica, Ana Paula Abreu, Francisco Ruiz-Pino, Ursula B. Kaiser, María J. Vázquez, Francisco Gaytan, Ana Claudia Latronico, Susana Sangiao-Alvarellos, Juan Carlos Roa
Publikováno v:
Endocrine Abstracts.
Autor:
Juan Carlos Roa, Ursula B. Kaiser, Leonor Pinilla, Susana Sangiao-Alvarellos, Ana Claudia Latronico, Maria Manfredi-Lozano, Violeta Heras, Francisco Gaytan, Vincent Prevot, Juan M. Castellano, Ana Paula Abreu, Denise D. Belsham, Manuel Tena-Sempere, Maribel Lara-Chica, Marco A. Calzado, Rosario Morrugares-Carmona, María J. Sanchez-Tapia, María Jesús Vázquez, Francisco Ruiz-Pino, Nathalie Jouy
Publikováno v:
PLoS Biology
PLoS Biology, Public Library of Science, 2019, 17 (11), pp.e3000532. ⟨10.1371/journal.pbio.3000532⟩
PLoS Biology, 2019, 17 (11), pp.e3000532. ⟨10.1371/journal.pbio.3000532⟩
RUC. Repositorio da Universidade da Coruña
instname
PLoS Biology, Vol 17, Iss 11, p e3000532 (2019)
PLoS Biology, Public Library of Science, 2019, 17 (11), pp.e3000532. ⟨10.1371/journal.pbio.3000532⟩
PLoS Biology, 2019, 17 (11), pp.e3000532. ⟨10.1371/journal.pbio.3000532⟩
RUC. Repositorio da Universidade da Coruña
instname
PLoS Biology, Vol 17, Iss 11, p e3000532 (2019)
Mkrn3, the maternally imprinted gene encoding the makorin RING-finger protein-3, has recently emerged as putative pubertal repressor, as evidenced by central precocity caused by MKRN3 mutations in humans; yet, the molecular underpinnings of this key