Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Maria Makitalo"'
Publikováno v:
Blood. 114:1243-1249
Megakaryocytes (MKs) undergo an endomitotic cell cycle, leading to polyploidy. We examined the expression of the flavoproteins and oxidative stress-promoting enzymes, NADPH oxidases (Nox's), in MKs because of their known role in promoting the cell cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559749ef48a490cc46138e2f3583634b
https://doi.org/10.1182/blood-2008-12-195883
https://doi.org/10.1182/blood-2008-12-195883
Autor:
Maria Makitalo, Hao G. Nguyen, Katya Ravid, Cynthia St. Hilaire, Dharmaraj Chinnappan, Dan Yang
Publikováno v:
The FASEB Journal. 23:2741-2748
High expression of Aurora-B has been observed in various cancers, and inhibition of this kinase has been shown to halt cellular proliferation. However, the mechanism of effect of Aurora-B on cellular transformation has not been fully explored. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1495d8087c460d7220500292378e58
https://doi.org/10.1096/fj.09-130963
https://doi.org/10.1096/fj.09-130963
Autor:
Paul Toselli, Matthew R. Jones, Barbara M. Schreiber, Hao G. Nguyen, Edward D. Lamperti, Maria Makitalo, David C. Seldin, Ying Zhang, Haralambos Gavras, Anil K. Chauhan, Dan Yang, Milka Koupenova, Cynthia St. Hilaire, Denisa D. Wagner, Katya Ravid
Publikováno v:
Journal of Clinical Investigation. 116:1913-1923
Adenosine has been described as playing a role in the control of inflammation, but it has not been certain which of its receptors mediate this effect. Here, we generated an A2B adenosine receptor-knockout/reporter gene-knock-in (A2BAR-knockout/report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65d846876f70fbe3b0abf1577689ee8d
https://doi.org/10.1172/jci27933
https://doi.org/10.1172/jci27933
Autor:
Nicholas Papadantonakis, Katya Ravid, Greg Martin, Maria Makitalo, Hao G. Nguyen, Joseph E. Italiano, Sunita Patel-Hett, Donald J. McCrann, Kenian Liu
Endomitosis in megakaryocytes (MKs) involves repeated DNA replication in the absence of cytokinesis and is a crucial part of MK development. However, chromosomal dynamics have never been observed in living MKs. We developed a new transgenic mouse mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b29dcd251bebabe66b854eadfd2b1e
https://europepmc.org/articles/PMC2861775/
https://europepmc.org/articles/PMC2861775/
Autor:
Matthew R. Jones, Guangyao Yu, Hao G. Nguyen, Hoou-Xiang Xie, Katya Ravid, Dan Yang, Maria Makitalo
Megakaryocyte (MK)–specific transgene expression has proved valuable in studying thrombotic and hemostatic processes. Constitutive expression of genes, however, could result in altered phenotypes due to compensatory mechanisms or lethality. To circ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98eea66df2e5d9bcdc97ac2110267ffb
https://europepmc.org/articles/PMC1895218/
https://europepmc.org/articles/PMC1895218/
Publikováno v:
Blood. 108:4235-4235
Megakaryocytes (MKs) can reach a ploidy level of greater than 32N (with 2N representing diploid chromosomes), while polyploidization is important for generating an adequate number of functional platelets. The MK population in the marrow intriguingly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbad9dffcc251a7e7d9a3b9c1aeb9554
https://doi.org/10.1182/blood.v108.11.4235.4235
https://doi.org/10.1182/blood.v108.11.4235.4235
Publikováno v:
Blood. 104:4196-4196
Expression of foreign or endogenous genes in vivo is an essential tool for following regulatory processes, including the control of gene expression. Constitutive expression of such genes throughout development often results with lethality due to adve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89ad0f460b5b6dcf81c18b3f178bf9da
https://doi.org/10.1182/blood.v104.11.4196.4196
https://doi.org/10.1182/blood.v104.11.4196.4196