Identification of Fast Progressors Among Patients With Nonalcoholic Steatohepatitis Using Machine Learning

Autor: Jörn M. Schattenberg, Maria-Magdalena Balp, Brenda Reinhart, Sanchita Porwal, Andreas Tietz, Marcos C. Pedrosa, Matt Docherty

Publikováno v: Gastro Hep Advances, Vol 3, Iss 1, Pp 101-108 (2024)

Background and Aims: There is a high unmet need to develop noninvasive tools to identify nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) patients at risk of fast progression to end-stage liver disease (ESLD). This study des

Externí odkaz: https://doaj.org/article/8a45e763c2394b37b5a87700e9f313ed

NASHmap: clinical utility of a machine learning model to identify patients at risk of NASH in real-world settings

Autor: Jörn M. Schattenberg, Maria-Magdalena Balp, Brenda Reinhart, Andreas Tietz, Stephane A. Regnier, Gorana Capkun, Qin Ye, Jürgen Loeffler, Marcos C. Pedrosa, Matt Docherty

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)

Abstract The NASHmap model is a non-invasive tool using 14 variables (features) collected in standard clinical practice to classify patients as probable nonalcoholic steatohepatitis (NASH) or non-NASH, and here we have explored its performance and pr

Externí odkaz: https://doaj.org/article/6b644a20498142279e3c1eb247923805

Disease burden and predictors associated with non-response to antihistamine-based therapy in chronic spontaneous urticaria

Autor: Weily Soong, MD, Dhaval Patil, MS, Irina Pivneva, PhD, James Signorovitch, PhD, Michael A. Wells, PharmD, Maria-Magdalena Balp, MD, Merin Kuruvilla, MD

Publikováno v: World Allergy Organization Journal, Vol 16, Iss 12, Pp 100843- (2023)

Background: H1-antihistamines (H1AH) are the first-line treatment for chronic spontaneous urticaria (CSU), but 50% of patients have inadequate disease control at standard doses. Objective: To assess the comorbidity burden and healthcare resource util

Externí odkaz: https://doaj.org/article/d99f1c7ee8ce429aabd2805f6a5cfd60

Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance

Autor: Katherine Johnson, Peter J. Leary, Olivier Govaere, Matthew J. Barter, Sarah H. Charlton, Simon J. Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M. Julia Brosnan, Jeremy F. Cobbold, Mattias Ekstedt, Guruprasad P. Aithal, Karine Clément, Jörn M. Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M. Anstee, Ann K. Daly, James Clark, Heather J. Cordell, Rebecca Darlay, Christopher P. Day, Tim Hardy, Yang-Lin Liu, Fiona Oakley, Jeremy Palmer, Rachel Queen, Kristy Wonders, Patrick M. Bossuyt, Adriaan G. Holleboom, Hadi Zafarmand, Yasaman Vali, Jenny Lee, Karine Clement, Raluca Pais, Detlef Schuppan, Michael Allison, Sergio Rodriguez Cuenca, Vanessa Pellegrinelli, Michele Vacca, Antonio Vidal-Puig, Tuulia Hyötyläinen, Aidan McGlinchey, Matej Orešič, Partho Sen, Jose Mato, Óscar Millet, Jean-Francois Dufour, Stephen Harrison, Stefan Neubauer, Michael Pavlides, Ferenc Mozes, Salma Akhtar, Rajarshi Banerjee, Matt Kelly, Elizabeth Shumbayawonda, Andrea Dennis, Charlotte Erpicum, Manuel Romero-Gomez, Rocío Gallego-Durán, Isabel Fernández, Morten Karsdal, Diana Leeming, Mette Juul Fisker, Elisabeth Erhardtsen, Daniel Rasmussen, Per Qvist, Antonia Sinisi, Estelle Sandt, Maria Manuela Tonini, Maurizio Parola, Chiara Rosso, Fabio Marra, Amalia Gastaldelli, Sven Francque, Stergios Kechagias, Hannele Yki-Järvinen, Kimmo Porthan, Saskia van Mil, George Papatheodoridis, Helena Cortez-Pinto, Luca Valenti, Salvatore Petta, Luca Miele, Andreas Geier, Christian Trautwein, Paul Hockings, Phil Newsome, David Wenn, Cecília Maria Pereira Rodrigues, Rémy Hanf, Pierre Chaumat, Christian Rosenquist, Aldo Trylesinski, Pablo Ortiz, Kevin Duffin, Carla Yunis, Melissa Miller, Theresa Tuthill, Judith Ertle, Ramy Younes, Leigh Alexander, Rachel Ostroff, Mette Skalshøi Kjær, Lars Friis Mikkelsen, Clifford Brass, Lori Jennings, Maria-Magdalena Balp, Miljen Martic, Guido Hanauer, Sudha Shankar, Richard Torstenson, Céline Fournier, Richard Ehman, Michael Kalutkiewicz, Kay Pepin, Joel Myers, Diane Shevell, Gideon Ho, Henrik Landgren, Rob Myers, Lynda Doward, Diane Whalley, James Twiss

Publikováno v: JHEP Reports, Vol 4, Iss 2, Pp 100409- (2022)

Background & Aims: Serum microRNA (miRNA) levels are known to change in non-alcoholic fatty liver disease (NAFLD) and may serve as useful biomarkers. This study aimed to profile miRNAs comprehensively at all NAFLD stages. Methods: We profiled 2,083 s

Externí odkaz: https://doaj.org/article/bf7c90fd285b4e33a8d02523458d147c

The burden of non-alcoholic steatohepatitis (NASH) among patients from Europe: A real-world patient-reported outcomes study

Autor: Maria-Magdalena Balp, Nancy Krieger, Raymond Przybysz, Nate Way, Jennifer Cai, Dion Zappe, Sarah Jane McKenna, Garth Wall, Nico Janssens, Elliot Tapper

Publikováno v: JHEP Reports, Vol 1, Iss 3, Pp 154-161 (2019)

Background & Aims: Data on the economic and humanistic burden of non-alcoholic steatohepatitis (NASH) are scarce. This study assessed the comparative burden of NASH, relative to a representative sample from the general population and a type 2 diabete

Externí odkaz: https://doaj.org/article/2c470badbfe9413faa72f9b3bb0fe0ea