Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Maria M. Simile"'
Autor:
Antonio Cigliano, Isabella Gigante, Marina Serra, Gianpaolo Vidili, Maria M. Simile, Sara Steinmann, Francesco Urigo, Eleonora Cossu, Giovanni M. Pes, Maria P. Dore, Silvia Ribback, Egle P. Milia, Elena Pizzuto, Serena Mancarella, Li Che, Rosa M. Pascale, Gianluigi Giannelli, Matthias Evert, Xin Chen, Diego F. Calvisi
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Background Intrahepatic cholangiocarcinoma (iCCA) is a lethal primary liver tumor characterized by clinical aggressiveness, poor prognosis, and scarce therapeutic possibilities. Therefore, new treatments are urgently needed to render this di
Externí odkaz:
https://doaj.org/article/4358a36380b8455e977ec4053d406fe2
Autor:
Sophie Klemm, Katja Evert, Kirsten Utpatel, Alexandra Muggli, Maria M. Simile, Xin Chen, Matthias Evert, Diego F. Calvisi, Alexander Scheiter
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-16 (2023)
Abstract Background Upregulation of the mitogen-activated protein kinase (MAPK) cascade is common in hepatocellular carcinoma (HCC). Neuroblastoma RAS viral oncogene homolog (NRAS) is mutated in a small percentage of HCC and is hitherto considered in
Externí odkaz:
https://doaj.org/article/de2d353499314a8ba83c34a067ed7892
Autor:
Antonio Cigliano, Maria M. Simile, Gianpaolo Vidili, Giovanni M. Pes, Maria P. Dore, Francesco Urigo, Eleonora Cossu, Li Che, Claudio Feo, Sara M. Steinmann, Silvia Ribback, Rosa M. Pascale, Matthias Evert, Xin Chen, Diego F. Calvisi
Publikováno v:
Medicina, Vol 60, Iss 7, p 1160 (2024)
Background and Objectives: Aberrant upregulation of fatty acid synthase (FASN), catalyzing de novo synthesis of fatty acids, occurs in various tumor types, including human hepatocellular carcinoma (HCC). Although FASN oncogenic activity seems to resi
Externí odkaz:
https://doaj.org/article/9b831399f08b4b718d5859120af5fc63
Autor:
Sara M. Steinmann, Anabel Sánchez-Martín, Elisabeth Tanzer, Antonio Cigliano, Giovanni M. Pes, Maria M. Simile, Laurent Desaubry, Jose J.G. Marin, Matthias Evert, Diego F. Calvisi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2055 (2023)
Hepatocellular carcinoma (HCC) is a primary liver tumor with high lethality and increasing incidence worldwide. While tumor resection or liver transplantation is effective in the early stages of the disease, the therapeutic options for advanced HCC r
Externí odkaz:
https://doaj.org/article/847229fe20d946069fe30916e4268bec
Autor:
Maria M. Simile, PhD, Antonio Cigliano, PhD, Panagiotis Paliogiannis, MD, Lucia Daino, PhD, Roberto Manetti, MD, Claudio F. Feo, MD, Diego F. Calvisi, MD, PhD, Francesco Feo, MD, Rosa M. Pascale, MD, PhD
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101239- (2022)
Absract: Background: GNMT (glycine N-methyltransferase) is a tumor suppressor gene, but the mechanisms mediating its suppressive activity are not entirely known. Methods: We investigated the oncosuppressive mechanisms of GNMT in human hepatocellular
Externí odkaz:
https://doaj.org/article/218581cb5a774421b5a196278751a96f
Publikováno v:
Metabolites, Vol 13, Iss 1, p 35 (2022)
Liver preneoplastic and neoplastic lesions of the genetically susceptible F344 and resistant BN rats cluster, respectively, with human HCC with better (HCCB) and poorer prognosis (HCCP); therefore, they represent a valid model to study the molecular
Externí odkaz:
https://doaj.org/article/5de0c292307f45979cea577070158f2c
Publikováno v:
Cells, Vol 11, Iss 3, p 409 (2022)
Alterations of methionine cycle in steatohepatitis, cirrhosis, and hepatocellular carcinoma induce MAT1A decrease and MAT2A increase expressions with the consequent decrease of S-adenosyl-L-methionine (SAM). This causes non-alcoholic fatty liver dise
Externí odkaz:
https://doaj.org/article/41756dfe0b1045c78c1fb1b7769b756e
Autor:
Rosa M. Pascale, Maria M. Simile, Graziella Peitta, Maria A. Seddaiu, Francesco Feo, Diego F. Calvisi
Publikováno v:
Cancers, Vol 11, Iss 10, p 1450 (2019)
Hepatocellular carcinoma (HCC) is a frequent human cancer and the most frequent liver tumor. The study of genetic mechanisms of the inherited predisposition to HCC, implicating gene−gene and gene−environment interaction, led to the discovery of m
Externí odkaz:
https://doaj.org/article/1678d3eee6014487bc11c983c361b0b4
Publikováno v:
Medicina, Vol 55, Iss 6, p 296 (2019)
Several researchers have analyzed the alterations of the methionine cycle associated with liver disease to clarify the pathogenesis of human hepatocellular carcinoma (HCC) and improve the preventive and the therapeutic approaches to this tumor. Diffe
Externí odkaz:
https://doaj.org/article/3f91ecad006f4692a3bb42e0f95fe141
Autor:
Rosa M. Pascale, Francesco Feo, Maria R. Muroni, Maria A. Seddaiu, Maria L. Tomasi, Maddalena Frau, Patrizia Virdis, Maria R. De Miglio, Maria M. Simile, Lucia Daino, Marcella Sini, Rossella Pellegrino, Sara Ladu, Floriana Meloni, Federico Pinna, Diego F. Calvisi
Supplementary Table 1 from Dual-Specificity Phosphatase 1 Ubiquitination in Extracellular Signal-Regulated Kinase–Mediated Control of Growth in Human Hepatocellular Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e675783a6cfecfa23e1d7dfe533808
https://doi.org/10.1158/0008-5472.22374290.v1
https://doi.org/10.1158/0008-5472.22374290.v1