Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Maria M. Konarska"'
Autor:
Katarzyna Matylla-Kulińska, Katarzyna Eysmont, Maria M. Konarska, Agata Jaskulska, Marcin Magnus
Publikováno v:
Molecular Cell. 75:538-548.e3
The RNA catalytic core of spliceosomes as visualized by cryoelectron microscopy (cryo-EM) remains unchanged at different stages of splicing. However, we demonstrate that mutations within the core of yeast U6 snRNA modulate conformational changes betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146ae3c8fcdc5c382bc8a62207e773af
https://doi.org/10.1016/j.molcel.2019.05.018
https://doi.org/10.1016/j.molcel.2019.05.018
Autor:
Zaher K. Otrock, Richard A. Padgett, Kenichi Yoshida, Hideki Makishima, Hirokazu Tanaka, Kenichi Chiba, Eric D. Hsi, Maria M. Konarska, Megan O. Nakashima, Michael J. Clemente, Jacqueline Boultwood, Satoru Miyano, Bartlomiej P Przychodzen, Yuichi Shiraishi, Jaroslaw P. Maciejewski, Seishi Ogawa, Amina Kurtovic-Kozaric, Jarnail Singh
Publikováno v:
Leukemia
Mutations of spliceosome components are common in myeloid neoplasms. One of the affected genes, PRPF8, encodes the most evolutionarily conserved spliceosomal protein. We identified either recurrent somatic PRPF8 mutations or hemizygous deletions in 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0eddae1815cb3c3df63952a5446c9b6
https://ora.ox.ac.uk/objects/uuid:faa220cc-24ac-474e-b6c9-fd80d7b16727
https://ora.ox.ac.uk/objects/uuid:faa220cc-24ac-474e-b6c9-fd80d7b16727
Publikováno v:
Molecular Cell. 34:333-343
The duplex formed between the branch site (BS) of a spliceosomal intron and its cognate sequence in U2 snRNA is important for spliceosome assembly and the first catalytic step of splicing. We describe the development of an orthogonal BS-U2 system in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b869a9da90372d7b4225af38982cad5
https://doi.org/10.1016/j.molcel.2009.03.012
https://doi.org/10.1016/j.molcel.2009.03.012
Autor:
Duncan J. Smith, Maria M. Konarska
Publikováno v:
RNA. 14:1975-1978
Recent work demonstrating the ability of spliceosomes purified after the second catalytic step of splicing to efficiently reverse both steps of the reaction provides answers to several unresolved questions regarding the splicing reaction, and raises
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62a37d4425fdfeaa570aa134804bda44
https://doi.org/10.1261/rna.1289808
https://doi.org/10.1261/rna.1289808
Publikováno v:
Molecular Cell. 30(6):657-666
The spliceosome is both compositionally and conformationally dynamic. Each transition along the splicing pathway presents an opportunity for progression, pausing, or discard, allowing splice site choice to be regulated throughout both the assembly an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d788eb0c0a1f5d5ebeaefa3c5191f30
Publikováno v:
Molecular Cell. 26(6):883-890
Pairing between U2 snRNA and the branch site of spliceosomal introns is essential for spliceosome assembly and is thought to be required for the first catalytic step of splicing. We have identified an RNA comprising the 5’ end of U2 snRNA and the 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1324c0afc6c4c1448303e0fdea2a51c
Publikováno v:
Molecular Cell. 21:543-553
Conformational change within the spliceosome is required between the first catalytic step of pre-mRNA splicing, when the branch site attacks the 5' splice site (SS), and the second step, when the 5' exon attacks the 3'SS. Little is known, however, ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6789a27950e9d72f8a1281078550b662
https://doi.org/10.1016/j.molcel.2006.01.017
https://doi.org/10.1016/j.molcel.2006.01.017
Autor:
Maria M. Konarska, Charles C. Query
Publikováno v:
Genes & Development. 19:2255-2260
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d75afae515ab6ed29b4907be0827711
https://doi.org/10.1101/gad.1363105
https://doi.org/10.1101/gad.1363105
Publikováno v:
The EMBO Journal. 23:1782-1791
The functional coupling of transcription and splicing has been reported both in vivo and in vitro, but the molecular mechanisms governing these interactions remain largely unknown. Here we show that p54(nrb), a transcription/splicing factor, associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e04a3eafaa0b948a21e27b06ec85a0c
https://doi.org/10.1038/sj.emboj.7600187
https://doi.org/10.1038/sj.emboj.7600187
Autor:
Yong-Zhen Xu, Tao Huang, Charles C. Query, Maria M. Konarska, Catherine M. Newnham, Sei Kameoka
Publikováno v:
The EMBO Journal. 23:376-385
Communication between U1 and U2 snRNPs is critical during pre-spliceosome assembly; yet, direct connections have not been observed. To investigate this assembly step, we focused on Prp5, an RNA-dependent ATPase of the DExD/H family. We identified hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15187dbba47137269f8f48aeee62bcb2
https://doi.org/10.1038/sj.emboj.7600050
https://doi.org/10.1038/sj.emboj.7600050