Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Maria M. Alves"'
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-12 (2023)
Abstract Background DNA hypermethylation is an epigenetic feature that modulates gene expression, and its deregulation is observed in cancer. Previously, we identified a neural-related DNA hypermethylation fingerprint in colon cancer, where most of t
Externí odkaz:
https://doaj.org/article/d113780cc53e4c6fa7d09ae35a59955b
Autor:
Laura E. Kuil, Naomi J.M. Kakiailatu, Jonathan D. Windster, Eric Bindels, Joke T.M. Zink, Gaby van der Zee, Robert M.W. Hofstra, Iain T. Shepherd, Veerle Melotte, Maria M. Alves
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107070- (2023)
Summary: The enteric nervous system (ENS) regulates many gastrointestinal functions including peristalsis, immune regulation and uptake of nutrients. Defects in the ENS can lead to severe enteric neuropathies such as Hirschsprung disease (HSCR). Zebr
Externí odkaz:
https://doaj.org/article/b7ec781be7a740e7809fef44bcc8fbf0
Autor:
Karen Ingrid Tasca, Camila Gonçalves Alves, Heloiza T.F.C. Silva, Cláudia P. Rubio Vidotto, Maria M. Alves Araújo, Flávia Daniela Zamoner, Cristiane A.A. Vicente, Ana Daniele Oliveira, Vanessa C.M. Rocha, Carlos M.C.B. Fortaleza
Publikováno v:
Brazilian Journal of Infectious Diseases, Vol 26, Iss , Pp 102433- (2022)
Introdução: Entre os casos diagnosticados de SARS-CoV-2, apesar de crianças e adolescentes serem os menos acometidos, no Brasil foram registrados cerca de 2.500 óbitos por Covid-19 nesta população. Em Botucatu/SP, a tendência de casos e intern
Externí odkaz:
https://doaj.org/article/0a163ff9b27048d889deb5f034faba1d
Autor:
Almira Zada, Laura E. Kuil, Bianca M. de Graaf, Naomi Kakiailatu, Jonathan D. Windster, Alice S. Brooks, Marjon van Slegtenhorst, Barbara de Koning, René M. H. Wijnen, Veerle Melotte, Robert M. W. Hofstra, Erwin Brosens, Maria M. Alves
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Background: Pediatric Intestinal Pseudo-obstruction (PIPO) is a congenital enteric disorder characterized by severe gastrointestinal (GI) dysmotility, without mechanical obstruction. Although several genes have been described to cause this disease, m
Externí odkaz:
https://doaj.org/article/88f91001bc774e99be4b2759acc6def2
Autor:
Carla Pereira Magalhães, Joaquim A. Ribeiro, Ana P. Guedes, Ana L. Arantes, Diana Z. Sousa, Alfons J. M. Stams, Maria M. Alves, Ana Júlia Cavaleiro
Publikováno v:
Microbial Biotechnology, Vol 13, Iss 4, Pp 962-973 (2020)
Summary Glycerol‐rich waste streams produced by the biodiesel, bioethanol and oleochemical industries can be treated and valorized by anaerobic microbial communities to produce methane. As current knowledge of the microorganisms involved in thermop
Externí odkaz:
https://doaj.org/article/a4a7cd257bd24ec8a136e29d0110f778
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
The Enteric Nervous System (ENS) is a large network of enteric neurons and glia that regulates various processes in the gastrointestinal tract including motility, local blood flow, mucosal transport and secretion. The ENS is derived from stem cells c
Externí odkaz:
https://doaj.org/article/cec757a843634b019eec00d957c1dc9a
Autor:
Katherine C. MacKenzie, Rhiana Garritsen, Rajendra K. Chauhan, Yunia Sribudiani, Bianca M. de Graaf, Tim Rugenbrink, Rutger Brouwer, Wilfred F. J. van Ijcken, Ivo de Blaauw, Alice S. Brooks, Cornelius E. J. Sloots, Conny J. H. M. Meeuwsen, René M. Wijnen, Donald F. Newgreen, Alan J. Burns, Robert M. W. Hofstra, Maria M. Alves, Erwin Brosens
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12354 (2021)
Patients with Hirschsprung disease (HSCR) do not always receive a genetic diagnosis after routine screening in clinical practice. One of the reasons for this could be that the causal mutation is not present in the cell types that are usually tested
Externí odkaz:
https://doaj.org/article/f7f6764065824070b5f3079e8362a7e4
Autor:
Almira Zada, Yuying Zhao, Danny Halim, Jonathan Windster, Herma C van der Linde, Jackleen Glodener, Sander Overkleeft, Bianca M de Graaf, Robert M Verdijk, Alice S Brooks, Iain Shepherd, Ya Gao, Alan J Burns, Robert M W Hofstra, Maria M Alves
Publikováno v:
Human Molecular Genetics, 32(1), 151-160. Oxford University Press
Filamin A (FLNA) is a cytoplasmic actin binding protein, recently shown to be expressed as a long and short isoform. Mutations in FLNA are associated with a wide spectrum of disorders, including an X-linked form of chronic intestinal pseudo-obstructi
Autor:
Jonathan D Windster, Andrea Sacchetti, Gerben J Schaaf, Eric MJ Bindels, Robert MW Hofstra, Rene MH Wijnen, Cornelius EJ Sloots, Maria M Alves
Publikováno v:
EMBO Reports, 24(4):e55789. Wiley-Blackwell
Efficient isolation of neurons and glia from the human enteric nervous system (ENS) is challenging because of their rare and fragile nature. Here, we describe a staining panel to enrich ENS cells from the human intestine by fluorescence-activated cel
Autor:
Maria M Alves, Erwin Brosens
Publikováno v:
Clinical and Translational Discovery. 3