Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Maria M Disotuar"'
Autor:
Peter Ahorukomeye, Maria M Disotuar, Joanna Gajewiak, Santhosh Karanth, Maren Watkins, Samuel D Robinson, Paula Flórez Salcedo, Nicholas A Smith, Brian J Smith, Amnon Schlegel, Briony E Forbes, Baldomero Olivera, Danny Hung-Chieh Chou, Helena Safavi-Hemami
Publikováno v:
eLife, Vol 8 (2019)
The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin to induce hypoglycemic shock in its prey. We recently showed that this venom insulin, Con-Ins G1, has unique characteristics relevant to the design of new insulin th
Externí odkaz:
https://doaj.org/article/71443f02920a4c85a8dd87031b11da69
Autor:
Joshua R. Lacsina, Ryan Kissinger, Johannes S. P. Doehl, Maria M. Disotuar, George Petrellis, Mara Short, Elliot Lowe, James Oristian, Daniel Sonenshine, Thiago DeSouza-Vieira
Publikováno v:
Frontiers in Tropical Diseases, Vol 5 (2024)
Infections caused by vector-borne pathogens impose a significant burden of morbidity and mortality in a global scale. In their quest for blood, hematophagous arthropods penetrate the host skin and may transmit pathogens by the bite. These pathogens a
Externí odkaz:
https://doaj.org/article/52a5528e4a67468f9b16012cd43658b9
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2719-2725 (2021)
Insulin derivatives such as insulin detemir and insulin degludec are U.S. Food and Drug Administration (FDA)-approved long-acting insulin currently used by millions of people with diabetes. These derivatives are modified in C-terminal B29 lysine to r
Externí odkaz:
https://doaj.org/article/e9bbce0b22c74cc1b83327e6a696433a
Autor:
Jinze Li, Maria M. Disotuar, Nai-Pin Lin, Jake A. Smith, Danny Hung-Chieh Chou, Steve L. Alam
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2719-2725 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Insulin derivatives such as insulin detemir and insulin degludec are U.S. Food and Drug Administration (FDA)-approved long-acting insulin currently used by millions of people with diabetes. These derivatives are modified in C-terminal B29 lysine to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1984559319e185f56741a54626eb56
http://www.sciencedirect.com/science/article/pii/S2211383520308017
http://www.sciencedirect.com/science/article/pii/S2211383520308017
Publikováno v:
Organic & Biomolecular Chemistry. 17:1703-1708
The introduction of solid-phase peptide synthesis in the 1960’s improved the chemical synthesis of both the A- and B-chains of insulin and insulin analogs. However, the subsequent elaboration of the synthetic peptides to generate active hormones co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc93e04e397fa77399a13f606462d7fd
https://doi.org/10.1039/c8ob01212a
https://doi.org/10.1039/c8ob01212a
Autor:
Bianca M. Nagata, Tiago D. Serafim, Fabiano Oliveira, Ian N. Moore, Eva Iniguez, Maria M. Disotuar, Claudio Meneses, Daniel E. Sonenshine, Valéria M. Borges, Shaden Kamhawi, Miguel P. Soares, Silvia Cardoso, Pedro Cecilio, Waldionê de Castro, Ranadhir Dey, Subir Karmakar, Jesus G. Valenzuela, Hira L. Nakhasi, Joshua R. Lacsina, Thiago DeSouza-Vieira
Publikováno v:
Cell Reports
Hematophagous vectors lacerate host skin and capillaries to acquire a blood meal, resulting in leakage of red blood cells (RBCs) and inflammation. Here, we show that heme oxygenase-1 (HO-1), a pleiotropic cytoprotective isoenzyme that mitigates heme-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f096ec08733c5d9c3fcd70c409c769cd
https://pubmed.ncbi.nlm.nih.gov/33113362
https://pubmed.ncbi.nlm.nih.gov/33113362
Autor:
Maria M. Disotuar, Xiaochun Xiong, Michael C. Lawrence, Danny Hung-Chieh Chou, Rahul Agrawal, Helena Safavi-Hemami, Nicholas A. Smith, Briony E. Forbes, Christopher A. MacRaild, Raymond S. Norton, John Gerbrandt Tasman Menting, Joanna Gajewiak, Xiaomin Wang, Xiao He, Brian J. Smith, Baldomero M. Olivera, Gabrielle Ghabash, Carlie Delaine, Simon J. Fisher
Publikováno v:
Nature structural & molecular biology
Human insulin and its current therapeutic analogs all show propensity, albeit varyingly, to self-associate into dimers and hexamers, which delays their onset of action and makes blood glucose management difficult for people with diabetes. Recently, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412a84f26b3e8ecd41533e3bed8b0925
https://pubmed.ncbi.nlm.nih.gov/32533129
https://pubmed.ncbi.nlm.nih.gov/32533129
Autor:
Hira Nakhasi, Valéria M. Borges, Bianca M. Nagata, Thiago DeSouza-Vieira, Silvia Cardoso, Pedro Cecilio, Eva Iniguez, Fabiano Oliveira, Jesus G. Valenzuela, Miguel P. Soares, Claudio Meneses, Waldionê de Castro, Subir Karmakar, Ian N. Moore, Joshua R. Lacsina, Ranadhir Dey, Shaden Kamhawi, Tiago D. Serafim, Daniel E. Sonenshine, Maria M. Disotuar
Publikováno v:
SSRN Electronic Journal.
Hematophagous vectors lacerate host skin and capillaries to acquire a blood meal resulting in leakage of red blood cells (RBCs) and inflammation. Here, we show that heme oxygenase-1 (HO-1), a pleiotropic cytoprotective isoenzyme that mitigates heme-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9099c0d94fb3e79dfaab9f679e079d79
https://doi.org/10.2139/ssrn.3595717
https://doi.org/10.2139/ssrn.3595717
Publikováno v:
Chemical Science. 8:2717-2722
We report an efficient, highly selective modification on the N-terminal amines of peptides and proteins using aldehyde derivatives via reductive alkylation. After modification of a library of unprotected peptides XYSKEASAL (X varies over 20 natural a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4597b4aedaf71b818fef0dba6e7d8f88
https://doi.org/10.1039/c6sc04744k
https://doi.org/10.1039/c6sc04744k
Publikováno v:
J Diabetes Sci Technol
Although insulin analogs have markedly improved glycemic control for people with diabetes, glycemic excursions still cause major health problems and complications. In particular, the narrow therapeutic window of current insulin therapy makes it extre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2096e01f16171148956b1b4f0a9062
https://europepmc.org/articles/PMC7196861/
https://europepmc.org/articles/PMC7196861/
