Tracking the stochastic fate of cells of the renin lineage after podocyte depletion using multicolor reporters and intravital imaging.

Autor: Natalya V Kaverina, Hiroyuki Kadoya, Diana G Eng, Michael E Rusiniak, Maria Luisa S Sequeira-Lopez, R Ariel Gomez, Jeffrey W Pippin, Kenneth W Gross, Janos Peti-Peterdi, Stuart J Shankland

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0173891 (2017)

Podocyte depletion plays a major role in focal segmental glomerular sclerosis (FSGS). Because cells of the renin lineage (CoRL) serve as adult podocyte and parietal epithelial cell (PEC) progenitor candidates, we generated Ren1cCre/R26R-ConfettiTG/WT

Externí odkaz: https://doaj.org/article/377f11c06fb4421e8b9d0334feb3b70e

A novel role for the histone modifier PRDM6 and an opportunity to understand hypertension

Autor: Jason P. Smith, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez

Publikováno v: Kidney International.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::438b4b80e56ee1b87e2baefc5c6f0d26
https://doi.org/10.1016/j.kint.2023.05.012

Abstract 090: Cells Of The Renin Lineage Promote Kidney Regeneration Post - Release Of Ureteral Obstruction In Neonatal Mice

Autor: Vidya K Nagalakshmi, Minghong Li, Silvia Medrano, Roberto A Gomez, Maria Luisa S Sequeira-Lopez

Publikováno v: Hypertension. 79

Renin, the rate-limiting enzyme of the renin-angiotensin system, is increased in the kidneys subjected to ureteral obstruction. We elucidated the changes and contribution of renin-producing cells (RPCs) and the cells of renin lineage (CoRL) during ki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b15d1e86d6cd1089c3b511e6ff7e71f
https://doi.org/10.1161/hyp.79.suppl_1.090

Deciphering the Identity of Renin Cells in Health and Disease

Autor: Alexandre de Goes Martini, Omar Guessoum, R. Ariel Gomez, Maria Luisa S. Sequeira-Lopez

Publikováno v: Trends Mol Med

Hypotension and changes in fluid-electrolyte balance pose immediate threats to survival. Juxtaglomerular cells respond to such threats by increasing the synthesis and secretion of renin. In addition, smooth muscle cells (SMCs) along the renal arterio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab3fc31529a922d9751c12e965e80787
https://doi.org/10.1016/j.molmed.2020.10.003

Comparative studies of renin-null zebrafish and mice provide new functional insights

Autor: Scott Hoffmann, Linda Mullins, Sebastien Rider, Cara Brown, Charlotte B. Buckley, Adrienne Assmus, Ziwen Li, Mariana Sierra Beltran, Neil Henderson, Jorge del Pozo, Alexandre De Goes Martini, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez, John Mullins

Publikováno v: Hoffmann, S, Mullins, L, Rider, S, Brown, C, Buckley, C B, Assmus, A, Li, Z, Sierra Beltran, M, Henderson, N, Del Pozo, J, De Goes Martini, A, Sequeira-Lopez, M L S, Gomez, R A & Mullins, J 2022, ' Comparative Studies of Renin-Null Zebrafish and Mice Provide New Functional Insights ', Hypertension, vol. 79, no. 3, HYPERTENSIONAHA12118600, pp. E56-E66 . https://doi.org/10.1161/HYPERTENSIONAHA.121.18600
Hypertension

Background: The renin-angiotensin system is highly conserved across vertebrates, including zebrafish, which possess orthologous genes coding for renin-angiotensin system proteins, and specialized mural cells of the kidney arterioles, capable of synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda34c051ae368b0d6399fd1c84a8a60
https://strathprints.strath.ac.uk/79186/1/Hoffman_etal_Hypertension_2022_Comparative_studies_of_renin_null_zebrafish_and_mice_provide_new_functional_insights.pdf