Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Maria Luisa S Sequeira Lopez"'
Autor:
Fenglin Wang, Jenny Ngo, Yuwen Li, Hongbing Liu, Chao-Hui Chen, Zubaida Saifudeen, Maria Luisa S Sequeira-Lopez, Samir S. El-Dahr
Publikováno v:
Epigenetics, Vol 16, Iss 11, Pp 1235-1250 (2021)
The epigenetic regulator Dot1, the only known histone H3K79 methyltransferase, has a conserved role in organismal development and homoeostasis. In yeast, Dot1 is required for telomeric silencing and genomic integrity. In Drosophila, Dot1 (Grappa) reg
Externí odkaz:
https://doaj.org/article/5d42d923eca444e0bdd6b5738e4a3c6b
Autor:
Brian C. Belyea, Araceli E. Santiago, Wilson A. Vasconez, Vidya K. Nagalakshmi, Fang Xu, Theodore C. Mehalic, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The hormone renin plays a crucial role in the regulation of blood pressure and fluid-electrolyte homeostasis. Normally, renin is synthesized by juxtaglomerular (JG) cells, a specialized group of myoepithelial cells located near the entrance
Externí odkaz:
https://doaj.org/article/660db11b5d0e49efb6c0e8f6c7c6430b
Autor:
Hirofumi Watanabe, Alexandre G. Martini, Evan A. Brown, Xiuyin Liang, Silvia Medrano, Shin Goto, Ichiei Narita, Lois J. Arend, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
Inhibitors of the renin-angiotensin system (RAS) are widely used to treat hypertension. Using mice harboring fluorescent cell lineage tracers, single-cell RNA-Seq, and long-term inhibition of RAS in both mice and humans, we found that deletion of ren
Externí odkaz:
https://doaj.org/article/ca6eb4fa4d434f72a8ba7e2dc1c9fd5e
Publikováno v:
Am J Physiol Renal Physiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b68f1b093dd35c24c192b1b39db3f86
https://doi.org/10.1152/ajprenal.00046.2023
https://doi.org/10.1152/ajprenal.00046.2023
Autor:
Andrea Schramm, Frank Schweda, Maria Luisa S. Sequeira-Lopez, Franz Hofmann, Peter Sandner, Jens Schlossmann
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Pharmacological inhibition of the renin–angiotensin–aldosterone system (RAAS) is, in combination with diuretics, the first-choice treatment for hypertension, although 10–20% of patients do not respond adequately. Next to the RAAS, the nitric ox
Externí odkaz:
https://doaj.org/article/f1dd0992956244cebdad3f17423f8eda
Publikováno v:
Kidney International.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::438b4b80e56ee1b87e2baefc5c6f0d26
https://doi.org/10.1016/j.kint.2023.05.012
https://doi.org/10.1016/j.kint.2023.05.012
Autor:
Alexandre G Martini, Jason P. Smith, Silvia Medrano, Nathan C. Sheffield, Maria Luisa S. Sequeira-Lopez, R. Ariel Gomez
Publikováno v:
bioRxiv
RationaleRenin cells are essential for survival. They control the morphogenesis of the kidney arterioles, and the composition and volume of our extracellular fluid, arterial blood pressure, tissue perfusion, and oxygen delivery. It is known that reni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abe27acb8471c4c2620d7ec67003e2f
https://europepmc.org/articles/PMC9882312/
https://europepmc.org/articles/PMC9882312/
Autor:
Vidya K Nagalakshmi, Minghong Li, Silvia Medrano, Roberto A Gomez, Maria Luisa S Sequeira-Lopez
Publikováno v:
Hypertension. 79
Renin, the rate-limiting enzyme of the renin-angiotensin system, is increased in the kidneys subjected to ureteral obstruction. We elucidated the changes and contribution of renin-producing cells (RPCs) and the cells of renin lineage (CoRL) during ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b15d1e86d6cd1089c3b511e6ff7e71f
https://doi.org/10.1161/hyp.79.suppl_1.090
https://doi.org/10.1161/hyp.79.suppl_1.090
Autor:
Maria Luisa S. Sequeira-Lopez, Robert L. Paxton, Douglas W. DeSimone, Hirofumi Watanabe, Bette J. Dzamba, Brian C. Belyea, Minghong Li, R. Ariel Gomez
Publikováno v:
Circ Res
Rationale: Renin-expressing cells are myoendocrine cells crucial for survival. They have been postulated to possess a pressure-sensing mechanism, a baroreceptor, which can detect slight changes in blood pressure and respond with precise and synchroni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3405a2d009e9110e07f66de7a2ab0bbf
https://doi.org/10.1161/circresaha.120.318711
https://doi.org/10.1161/circresaha.120.318711
Autor:
Natalya V Kaverina, Hiroyuki Kadoya, Diana G Eng, Michael E Rusiniak, Maria Luisa S Sequeira-Lopez, R Ariel Gomez, Jeffrey W Pippin, Kenneth W Gross, Janos Peti-Peterdi, Stuart J Shankland
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173891 (2017)
Podocyte depletion plays a major role in focal segmental glomerular sclerosis (FSGS). Because cells of the renin lineage (CoRL) serve as adult podocyte and parietal epithelial cell (PEC) progenitor candidates, we generated Ren1cCre/R26R-ConfettiTG/WT
Externí odkaz:
https://doaj.org/article/377f11c06fb4421e8b9d0334feb3b70e