Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Maria Luisa Sá e Melo"'
1
Neurosteroids: Can a 2alpha,3alpha-epoxy ring make up for the 3alpha-hydroxyl group?
Autor: Zdena Kristofikova, Pavel Mareš, Alexander Kasal, M. Manuel Cruz Silva, Alcino J. L. Leitao, Miloš Buděšínský, Maria Luisa Sá e Melo
Publikováno v: Steroids. 105
Seven steroid epoxides were prepared from 5α-pregn-2-en-20-one and 5α-pregn-3-en-20-one and their side-chain derivatives. All compounds were tested in vitro for binding to γ-aminobutyric acid (GABAA) receptor, some of them also in vivo for anticon
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7df5a85190d76f1e7e9e8c8fb0664b8
https://pubmed.ncbi.nlm.nih.gov/26631551
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3
A versatile and straightforward approach to the 21-oxidation of β-substituted and α,β-unsaturated 20-oxosteroids
Autor: Maria José S. M. Moreno, Saul P. da Costa, André S. Campos Neves, R. M. L. M. Martins, Maria Luisa Sá e Melo
Publikováno v: Tetrahedron. 54:13877-13886
21-Hydroxylation and acetoxylation of 20-oxosteroids, either α,β-unsaturated or β-substituted, were successfully achieved through oxidation of the corresponding silyl enol ethers with m -CPBA followed by smooth hydrolytic cleavage of the 21-alkyls
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88835ed782d25b598c135bc984613eba
https://doi.org/10.1016/s0040-4020(98)00854-0
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4
Expedient synthesis of lactone analogues of formestane as new potential aromatase inhibitors
Autor: José A. Paixão, Elisiário J. Tavares da Silva, Maria Luisa Sá e Melo, Maria-José M. Almeida, L. C. R. Andrade, M. M. R. R. Costa, André S. Campos Neves
Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :3487-3490
A convenient synthetic strategy for the preparation of ring-D lactones of the androstane derivatives 4, 5 and 6 has been achieved through a high yielding, three-step sequence. Baeyer–Villiger oxidation of 3α,4β-dihydroxy-5α-androstan-17-one 3, p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1187a2728b40078138f46ad80adb5226
https://doi.org/10.1039/a705601j
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6
ChemInform Abstract: Improved Syntheses of Aromatase Inhibitors and Neuroactive Steroids Efficient Oxidations and Reductions at Key Positions for Bioactivity
Autor: Jorge A. R. Salvador, Elisiário J. Tavares da Silva, André S. Campos Neves, Maria José S. M. Moreno, Saul P. da Costa, R. M. L. M. Martins, Maria Luisa Sá e Melo
Publikováno v: ChemInform. 30
An Henbest reduction, followed by the preparation of a silyl enol ether and oxidation in situ with m-CPBA has led to the neurosteroids 3α-hydroxy- and 3α,21-dihydroxy-5α-pregnanolones. Using testosterone as starting material, a new short synthesis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::391be19f8f4dace6d8df1433af7c3cab
https://doi.org/10.1002/chin.199928219
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7
On the selectivity of Mycobacterium sp. NRRL B-3805 as steroid producer
Autor: Maria Luisa Sá e Melo, M. Manuel Cruz Silva, Marco P.C. Marques, Pedro Fernandes, Joaquim M. S. Cabral
Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
http://www.sciencedirect.com/science/article/B6T3C-4PB7582-7P/1/6704530c9694fd9eaf27304a215ae765
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca6e383b7c875a2feddabf0ca8dac77
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8
Improved syntheses of aromatase inhibitors and neuroactive steroids efficient oxidations and reductions at key positions for bioactivity
Autor: Saul P. da Costa, Elisiário J. Tavares da Silva, R. M. L. M. Martins, Jorge A. R. Salvador, Maria Luisa Sá e Melo, André S. Campos Neves, Maria José S. M. Moreno
Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
An Henbest reduction, followed by the preparation of a silyl enol ether and oxidation in situ with m-CPBA has led to the neurosteroids 3[alpha]-hydroxy- and 3[alpha],21-dihydroxy-5[alpha]-pregnanolones. Using testosterone as starting material, a new
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313ada44c720956d993318326454d9b4
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9
Novel approach to the synthesis of the aromatase inhibitor 4-hydroxyandrost-4-ene-3,17-dione (4-OHA)
Autor: André S. Campos Neves, Elisiário J. Tavares da Silva, Maria Luisa Sá e Melo
Publikováno v: J. Chem. Soc., Perkin Trans. 1. :1649-1650
A straightforward synthesis of the title compound is achieved through a novel approach, comprising the oxidation of the easily available 5α-androst-3-en-17-one 1 in two sequential steps to yield the kinetic diosphenol 4, which gives the desired 4-OH
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02d22d9c58fbe72d9713ed1aefb46332
https://doi.org/10.1039/p19960001649
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