Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Maria Luisa Paçó-Larson"'
1
Akademický článek
Expression signatures of DNA repair genes correlate with survival prognosis of astrocytoma patients
Autor: Juliana Ferreira de Sousa, Raul Torrieri, Rodolfo Bortolozo Serafim, Luis Fernando Macedo Di Cristofaro, Fábio Dalbon Escanfella, Rodrigo Ribeiro, Dalila Lucíola Zanette, Maria Luisa Paçó-Larson, Wilson Araujo da Silva, Daniela Pretti da Cunha Tirapelli, Luciano Neder, Carlos Gilberto Carlotti, Valeria Valente
Publikováno v: Tumor Biology, Vol 39 (2017)
Astrocytomas are the most common primary brain tumors. They are very resistant to therapies and usually progress rapidly to high-grade lesions. Here, we investigated the potential role of DNA repair genes in astrocytoma progression and resistance. To
Externí odkaz: https://doaj.org/article/c3839c27117e4735893861ef565d7455
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2
Akademický článek
Using Postmortem hippocampi tissue can interfere with differential gene expression analysis of the epileptogenic process.
Autor: João Paulo Lopes Born, Heloisa de Carvalho Matos, Mykaella Andrade de Araujo, Olagide Wagner Castro, Marcelo Duzzioni, José Eduardo Peixoto-Santos, João Pereira Leite, Norberto Garcia-Cairasco, Maria Luisa Paçó-Larson, Daniel Leite Góes Gitaí
Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182765 (2017)
Neuropathological studies often use autopsy brain tissue as controls to evaluate changes in protein or RNA levels in several diseases. In mesial temporal lobe epilepsy (MTLE), several genes are up or down regulated throughout the epileptogenic and ch
Externí odkaz: https://doaj.org/article/14e2e633eefd4b9d9673fe4acc9a9600
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3
Akademický článek
Identification of microRNAs with Dysregulated Expression in Status Epilepticus Induced Epileptogenesis.
Autor: Mykaella Andrade de Araújo, Thalita Ewellyn Batista Sales Marques, Shirley Octacílio-Silva, Carmem Lúcia de Arroxelas-Silva, Marília Gabriella Alves Goulart Pereira, José Eduardo Peixoto-Santos, Ludmyla Kandratavicius, João Pereira Leite, Norberto Garcia-Cairasco, Olagide Wagner Castro, Marcelo Duzzioni, Geraldo Aleixo Passos, Maria Luisa Paçó-Larson, Daniel Leite Góes Gitaí
Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0163855 (2016)
The involvement of miRNA in mesial temporal lobe epilepsy (MTLE) pathogenesis has increasingly become a focus of epigenetic studies. Despite advances, the number of known miRNAs with a consistent expression response during epileptogenesis is still sm
Externí odkaz: https://doaj.org/article/3ab12e1be6624d61ac837ded01ecd368
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4
Akademický článek
Diurnal Variation Has Effect on Differential Gene Expression Analysis in the Hippocampus of the Pilocarpine-Induced Model of Mesial Temporal Lobe Epilepsy.
Autor: Evelin Antonieli da Silva Santos, Thalita Ewellyn Batista Sales Marques, Heloísa de Carvalho Matos, João Pereira Leite, Norberto Garcia-Cairasco, Maria Luisa Paçó-Larson, Daniel Leite Góes Gitaí
Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0141121 (2015)
The molecular mechanisms underlying epileptogenesis have been widely investigated by differential gene expression approach, especially RT-qPCR methodology. However, controversial findings highlight the occurrence of unpredictable sources of variance
Externí odkaz: https://doaj.org/article/6a557b4c043f4f039a4310a8841d107f
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5
Akademický článek
Identification of endogenous reference genes for the analysis of microRNA expression in the hippocampus of the pilocarpine-induced model of mesial temporal lobe epilepsy.
Autor: Mykaella Andrade de Araújo, Thalita Ewellyn Batista Sales Marques, Jamile Taniele-Silva, Fernanda Maria de Araújo Souza, Tiago Gomes de Andrade, Norberto Garcia-Cairasco, Maria Luisa Paçó-Larson, Daniel Leite Góes Gitaí
Publikováno v: PLoS ONE, Vol 9, Iss 6, p e100529 (2014)
Real-time quantitative RT-PCR (qPCR) is one of the most powerful techniques for analyzing miRNA expression because of its sensitivity and specificity. However, in this type of analysis, a suitable normalizer is required to ensure that gene expression
Externí odkaz: https://doaj.org/article/79a4a522dd514f67ae6e99393d6d413b
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6
Akademický článek
Modulation of HJURP (Holliday Junction-Recognizing Protein) levels is correlated with glioblastoma cells survival.
Autor: Valeria Valente, Rodolfo Bortolozo Serafim, Leonardo Cesar de Oliveira, Fernando Soares Adorni, Raul Torrieri, Daniela Pretti da Cunha Tirapelli, Enilza Maria Espreafico, Sueli Mieko Oba-Shinjo, Suely Kazue Nagahashi Marie, Maria Luisa Paçó-Larson, Carlos Gilberto Carlotti
Publikováno v: PLoS ONE, Vol 8, Iss 4, p e62200 (2013)
BACKGROUND: Diffuse astrocytomas are the most common type of primary brain cancer in adults. They present a wide variation in differentiation and aggressiveness, being classified into three grades: low-grade diffuse astrocytoma (grade II), anaplastic
Externí odkaz: https://doaj.org/article/f0436f77d9c24362b2b6e4bb508f6be9
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7
Akademický článek
Validation of suitable reference genes for expression studies in different pilocarpine-induced models of mesial temporal lobe epilepsy.
Autor: Thalita Ewellyn Batista Sales Marques, Leila Rodrigues de Mendonça, Marília Gabriela Pereira, Tiago Gomes de Andrade, Norberto Garcia-Cairasco, Maria Luisa Paçó-Larson, Daniel Leite Góes Gitaí
Publikováno v: PLoS ONE, Vol 8, Iss 8, p e71892 (2013)
It is well recognized that the reference gene in a RT-qPCR should be properly validated to ensure that gene expression is unaffected by the experimental condition. We investigated eight potential reference genes in two different pilocarpine PILO-mode
Externí odkaz: https://doaj.org/article/07e876b00fdc4448924e64816253e52b
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8
Using Postmortem hippocampi tissue can interfere with differential gene expression analysis of the epileptogenic process
Autor: Norberto Garcia-Cairasco, João Pereira Leite, Daniel Leite Góes Gitaí, Mykaella Andrade de Araújo, Maria Luisa Paçó-Larson, Jose Eduardo Peixoto-Santos, Heloisa de Carvalho Matos, Marcelo Duzzioni, João Paulo Lopes Born, Olagide W. Castro
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE
PLoS ONE, Vol 12, Iss 8, p e0182765 (2017)
Neuropathological studies often use autopsy brain tissue as controls to evaluate changes in protein or RNA levels in several diseases. In mesial temporal lobe epilepsy (MTLE), several genes are up or down regulated throughout the epileptogenic and ch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd61825278f0e2474231555dd29bfc3
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9
Genes e epilepsia II: expressão gênica diferencial Genes and epilepsy II: differential gene expression in epilepsy
Autor: Rodrigo N. Romcy-Pereira, Daniel L. G. Gitaí, Lívia L. G. Gitaí, João P. Leite, Norberto Garcia-Cairasco, Maria Luisa Paçó-Larson
Publikováno v: Revista da Associação Médica Brasileira, Vol 54, Iss 5, Pp 461-466 (2008)
Nesta revisão, introduzimos abordagens investigativas, assim como discutimos os principais achados de expressão gênica diferencial em tecido epiléptico humano e em modelos experimentais. As alterações observadas no cérebro de indivíduos epil
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::9bb595e7be9fc33063a0b87fe8828a5d
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302008000500022
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10
Genes e epilepsia I: epilepsia e alterações genéticas
Autor: Maria Luisa Paçó-Larson, Norberto Garcia-Cairasco, João Pereira Leite, Rodrigo Neves Romcy-Pereira, Daniel Leite Góes Gitaí, Lívia Leite Góes Gitaí
Publikováno v: Revista da Associação Médica Brasileira v.54 n.3 2008
Revista da Associação Médica Brasileira
Associação Médica Brasileira (AMB)
instacron:AMB
Revista da Associação Médica Brasileira, Volume: 54, Issue: 3, Pages: 272-278, Published: JUN 2008
INTRODUÇÃO: Epilepsia é uma desordem neurológica caracterizada por crises espontâneas e recorrentes, que afeta de 2% a 3 % da população mundial. As crises epilépticas refletem atividade elétrica anormal e paroxística, preferencialmente em u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9178034b32c27fb064c9afd8a8d21d59
https://doi.org/10.1590/s0104-42302008000300023
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