Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Maria Luisa Lucero"'
Autor:
Ignacio Ortega, John C. Lukas, Ana Gonzalo, Maria Luisa Lucero, Valvanera Vozmediano, Monica Rodriguez
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 39:33-41
Modern pharmacometrics can integrate and leverage all prior proprietary and public knowledge. Such methods can be used to scale across species or comparators, perform clinical trial simulation across alternative designs, confirm hypothesis and potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c084792e574c4af4439a03e7255c0d
https://doi.org/10.1007/s13318-013-0131-3
https://doi.org/10.1007/s13318-013-0131-3
Publikováno v:
Drug and Chemical Toxicology. 35:18-24
Knowledge of the biotransformation of oral H₁ antihistamines is clinically important because it can define their pharmacokinetic profile through possible effects on absorption (i.e., first-pass metabolism) and elimination. Further, clinically signi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42ddd2cb4cddc794c36c4fdb32f8cc9
https://doi.org/10.3109/01480545.2012.682651
https://doi.org/10.3109/01480545.2012.682651
Publikováno v:
Drug and Chemical Toxicology. 35:1-7
This study evaluated the tissue distribution of total radioactivity in male albino, male pigmented, and time-mated female albino rats after oral administration of a single dose of [¹⁴C]-bilastine (20 mg/kg). Although only 1 animal was analyzed at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f132cf1818342673975f7e567d439248
https://doi.org/10.3109/01480545.2012.682650
https://doi.org/10.3109/01480545.2012.682650
Autor:
Szilvia Gedey, Eniko Ioja, Mirza Jahic, Itziar Soengas, Nerea Leal, Alvaro Ganza, Dallas Bednarczyk, Maria Luisa Lucero, Ana Gonzalo
Publikováno v:
Drug and Chemical Toxicology. 35:8-17
Membrane transporters play a significant role in facilitating transmembrane drug movement. For new pharmacological agents, it is important to evaluate potential interactions (e.g., substrate specificity and/or inhibition) with human transporters that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::892e6473312a468d1d1f37fc4bf15bb4
https://doi.org/10.3109/01480545.2012.682653
https://doi.org/10.3109/01480545.2012.682653
Autor:
Maria Luisa, Lucero, Ana, Gonzalo, Alvaro, Ganza, Nerea, Leal, Itziar, Soengas, Eniko, Ioja, Szilvia, Gedey, Mirza, Jahic, Dallas, Bednarczyk
Publikováno v:
Drug and chemical toxicology. 35
Membrane transporters play a significant role in facilitating transmembrane drug movement. For new pharmacological agents, it is important to evaluate potential interactions (e.g., substrate specificity and/or inhibition) with human transporters that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58f7a8b8051ca20f2524c017a209ad65
https://pubmed.ncbi.nlm.nih.gov/22616811
https://pubmed.ncbi.nlm.nih.gov/22616811
Publikováno v:
Drug and chemical toxicology. 35
As part of the bilastine development program, and as mandated by regulatory authorities, several studies were performed with oral bilastine in different animal species to evaluate its toxicity profile. Toxicokinetic analyses conducted in tandem to ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dfae3fae7e2ee3534d78b686a19d0d0
https://pubmed.ncbi.nlm.nih.gov/22616813
https://pubmed.ncbi.nlm.nih.gov/22616813
Autor:
Ander Sologuren, Nerea Leal, Leire de la Fuente, Nerea Jauregizar, Maria Luisa Lucero, Monica Rodriguez
Publikováno v:
Clinical pharmacokinetics. 48(8)
To model the pharmacokinetic and pharmacodynamic relationship of bilastine, a new histamine H(1) receptor antagonist, from single- and multiple-dose studies in healthy adult subjects.The pharmacokinetic model was developed from different single-dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5d0b839965733e703f9140fd8e82c7
https://pubmed.ncbi.nlm.nih.gov/19705924
https://pubmed.ncbi.nlm.nih.gov/19705924
Publikováno v:
Neuropharmacology. 52(3)
Serotonin (5-HT) and 5-HT(1A) receptors have been suggested to play a pivotal role in the mechanism of action of antidepressant drugs, particularly in the case of selective serotonin reuptake inhibitors (SSRIs). In the rat learned helplessness (LH) p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7101dc5bc2975009e115c20acb4f9a2c
https://pubmed.ncbi.nlm.nih.gov/17141811
https://pubmed.ncbi.nlm.nih.gov/17141811
Autor:
Ana Gonzalo, Maria Luisa Lucero, Aurelio Orjales, Leire de la Fuente, John C. Lukas, Fátima Ortega, Rosario Calvo, Antonio Quintana, Elena Suarez, Nerea Jauregizar
Publikováno v:
Pharmaceutical research. 22(11)
The twofold aim of this study was to characterize in vivo in rats the pharmacokinetics (PK) and pharmacodynamics (PD) of L6-OH, a metabolite of lerisetron with in vitro pharmacological activity, and evaluate the extent to which L6-OH contributes to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2d8b4bbe3cef75004efe3e55616284
https://pubmed.ncbi.nlm.nih.gov/16158214
https://pubmed.ncbi.nlm.nih.gov/16158214
Publikováno v:
Toxicology Letters. 196:S166-S167
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb5184163aab73d1f072d6232cbb0eb3
https://doi.org/10.1016/j.toxlet.2010.03.570
https://doi.org/10.1016/j.toxlet.2010.03.570