Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Maria Luisa Guerriero"'
Autor:
Nicolas Floc'h, Maria Luisa Guerriero, Antonio Ramos-Montoya, Barry R. Davies, Jonathan Cairns, Natasha A. Karp
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 11 (2018)
The high attrition rate of preclinical agents entering oncology clinical trials has been associated with poor understanding of the heterogeneous patient response, arising from limitations in the preclinical pipeline with cancer models. Patient-derive
Externí odkaz:
https://doaj.org/article/fbe31529bc76498fa1d09b256d8e05d0
Publikováno v:
Electronic Proceedings in Theoretical Computer Science, Vol 19, Iss Proc. FBTC 2010, Pp 55-69 (2010)
Compositionality is a key feature of process algebras which is often cited as one of their advantages as a modelling technique. It is certainly true that in biochemical systems, as in many other systems, model construction is made easier in a formali
Externí odkaz:
https://doaj.org/article/ff37dddda6f2419db7c6239964180ee2
Publikováno v:
Electronic Proceedings in Theoretical Computer Science, Vol 19, Iss Proc. FBTC 2010, Pp 1-19 (2010)
Circadian clocks are oscillatory genetic networks that help organisms adapt to the 24-hour day/night cycle. The clock of the green alga Ostreococcus tauri is the simplest plant clock discovered so far. Its many advantages as an experimental system fa
Externí odkaz:
https://doaj.org/article/b325c9d11477426494892859217607a5
Publikováno v:
Electronic Proceedings in Theoretical Computer Science, Vol 11, Iss Proc. MeCBIC 2009, Pp 71-90 (2009)
The vast majority of biochemical systems involve the exchange of information between different compartments, either in the form of transportation or via the intervention of membrane proteins which are able to transmit stimuli between bordering compar
Externí odkaz:
https://doaj.org/article/58f9057bce0f48519e396a511075bbd0
Autor:
Malgorzata Milewska, David Romano, Ana Herrero, Maria Luisa Guerriero, Marc Birtwistle, Franz Quehenberger, Stefan Hatzl, Boris N Kholodenko, Oreste Segatto, Walter Kolch, Armin Zebisch
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129859 (2015)
BRAF functions in the RAS-extracellular signal-regulated kinase (ERK) signaling cascade. Activation of this pathway is necessary to mediate the transforming potential of oncogenic BRAF, however, it may also cause a negative feedback that inhibits the
Externí odkaz:
https://doaj.org/article/f289658d462e49cca8af4cef2c865ae6
Autor:
Bairu Zhang, Philip Hopcroft, Ganesh Kadamur, Maria Luisa Guerriero, Andreas K. Hock, Avid M. Afzal, Elizaveta Semenova, Stanley E. Lazic
A proteolysis targeting chimera (PROTAC) is a new technology that marks proteins for degradation in a highly specific manner. During screening, PROTAC compounds are tested in concentration-response (CR) assays to determine their potency, and paramete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1de35be350fbe7d745277605181abf
https://doi.org/10.1101/2020.11.13.379883
https://doi.org/10.1101/2020.11.13.379883
Autor:
Mike Firth, Maria Luisa Guerriero, Samantha Peel, Adam Corrigan, Douglas Ross-Thriepland, Patrick J. O'Shea, Aurélie Bornot
Publikováno v:
SLAS discovery : advancing life sciences RD. 25(6)
Genome-wide arrayed CRISPR screening is a powerful method for drug target identification as it enables exploration of the effect of individual gene perturbations using diverse highly multiplexed functional and phenotypic assays. Using high-content im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40729adfc931350de7ef5777ad1798a6
https://pubmed.ncbi.nlm.nih.gov/32394775
https://pubmed.ncbi.nlm.nih.gov/32394775
Autor:
Stacey Price, Erica Banks, Hannah Thorpe, James E. Brownell, Matthias Pfeifer, Paul Smith, Jonathan S. Brammeld, Ultan McDermott, Shanade Dunn, Nin Guan, Aurélie Bornot, Maria Luisa Guerriero, Matthew J. Martin, James Pilling, Daniel O'Neill, Davide Gianni
Publikováno v:
Cancer Research. 81:1100-1100
10-20% of lung adenocarcinoma patients harbour activating mutations in EGFR. Although treatment with the EGFR kinase inhibitor osimertinib has improved overall survival in such patients, almost all patients ultimately develop drug resistance. In many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48b6070dc21a77a94ddac8f145eaa682
https://doi.org/10.1158/1538-7445.am2021-1100
https://doi.org/10.1158/1538-7445.am2021-1100
Publikováno v:
Georgoulas, A & Guerriero, M L 2013, ' A Software Interface Between the Narrative Language and Bio-PEPA ', Electronic Proceedings in Theoretical Computer Science, vol. 293, pp. 51-65 . https://doi.org/10.1016/j.entcs.2013.02.018
We present a software tool for the automatic translation of models from the Narrative Language, a semi-formal language for biological modelling, into the Bio-PEPA process algebra. This provides biologists with an easy way to describe systems and at t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5833466f93144dc4acb124a9763ab951
Publikováno v:
Electronic Notes in Theoretical Computer Science. 227:77-95
Compartments and membranes play an important role in cell biology. Therefore it is highly desirable to be able to represent them in modelling languages for biology. Bio-PEPA is a language for the modelling and analysis of biochemical networks; in its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ed919a8c714a541c230e26affa8574
https://doi.org/10.1016/j.entcs.2008.12.105
https://doi.org/10.1016/j.entcs.2008.12.105