The Role of the Inhibitory Ligand HVEM and Its Receptors CD160 and BTLA in the Regulation of Anti-retroviral T Cell Responses

Autor: Paul David, Jaana Westmeier, Malgorzata Drabczyk-Pluta, Tanja Werner, Julia Ickler, Sandra Francois, Wibke Bayer, Kathrin Sutter, Maria Luisa Del Rio, Jose-Ignacio Rodriguez-Barbosa, Ulf Dittmer, Gennadiy Zelinskyy

Publikováno v: Frontiers in Virology, Vol 2 (2022)

Specific CD8+ T cells are crucial for the control of viruses. However, during many chronic viral infections these cells become dysfunctional. Immune checkpoint receptors, like PD-1 expressed on CD8+ T cells, contribute to this functional suppression

Externí odkaz: https://doaj.org/article/b159ccee1050406998b106e8b901a932

Differential Engraftment of Parental A20 PD-L1 WT and PD-L1 KO Leukemia Cells in Semiallogeneic Recipients in the Context of PD-L1/PD-1 Interaction and NK Cell-Mediated Hybrid Resistance

Autor: Maria-Luisa del Rio, Jose-Antonio Perez-Simon, Jose-Ignacio Rodriguez-Barbosa

Publikováno v: BULERIA. Repositorio Institucional de la Universidad de León
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The contribution of natural killer (NK) cells to tumor rejection in the context of programmed death-ligand 1/programmed death 1 (PD-L1/PD-1) blockade is a matter of intense debate. To elucidate the role of PD-L1 expression on tumor cells and the func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334d77432ac829972be4f0695104ff0c
http://hdl.handle.net/10261/305412

The impact of CD160 deficiency on alloreactive CD8 T cell responses and allograft rejection

Autor: Laurent Tesson, Jean-Marie Heslan, Raúl Fernández-González, Ignacio Anegon, Julia L. Gutiérrez-Arroyo, Alfonso Gutiérrez-Adán, Leo Buhler, José A. Pérez-Simón, Jose-Ignacio Rodriguez-Barbosa, Tuan H. Nguyen, Maria-Luisa del Rio

Publikováno v: BULERIA. Repositorio Institucional de la Universidad de León
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[EN] CD160 is a member of the immunoglobulin superfamily with a pattern of expression mainly restricted to cytotoxic cells. To assess the functional relevance of the HVEM/CD160 signaling pathway in allogeneic cytotoxic responses, exon 2 of the CD160

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fe17c4b65a7b0c640a7276a7099f53
http://hdl.handle.net/20.500.12792/6224

Balance between Hosts and Guests: The Key to Sustainable Tourism in a Heritage City

Autor: Manuel Rama, Emilio Carral, Sara González-García, Elías Torres-Feijó, Maria Luisa del Rio, María Teresa Moreira, Gumersindo Feijoo

Publikováno v: Sustainability; Volume 14; Issue 20; Pages: 13253

A sustainable city implies socio-economic characteristics that allow citizens to maintain a certain quality of life. However, the effect of overtourism in some tourist cities negatively affects the community. In this study, a methodology was develope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f046033d8580c972886477be63a5cd64
https://doi.org/10.3390/su142013253

The role of TNFR2 and DR3 in the in vivo expansion of tregs in T Cell depleting transplantation regimens

Autor: Pascal Schneider, Leo Buhler, Luis Graca, Jose-Ignacio Rodriguez-Barbosa, José A. Pérez-Simón, Maria-Luisa del Rio

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 3347, p 3347 (2020)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

This article belongs to the Special Issue Trends in Molecular Research for Transplantation Immunology.
Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self through cell-intrinsic and cell-extrinsic mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3c376efdeb9af44f8cec3cbe3e6a33
https://hdl.handle.net/10451/46428