Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Maria Ludovica, Macchia"'
Autor:
Emanuele Fornasier, Maria Ludovica Macchia, Gabriele Giachin, Alice Sosic, Matteo Pavan, Mattia Sturlese, Cristiano Salata, Stefano Moro, Barbara Gatto, Massimo Bellanda, Roberto Battistutta
Publikováno v:
'Acta Crystallographica D ', vol: 78, pages: 363-378 (2022)
The SARS-CoV-2 main protease (Mpro) has a pivotal role in mediating viral genome replication and transcription of the coronavirus, making it a promising target for drugs against the COVID-19 pandemic. Here, a crystal structure is presented in which M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965673c7a8083601ad805f3cca624e6b
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:59489
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:59489
Autor:
Léa El Khoury, Zhifeng Jing, Alberto Cuzzolin, Alessandro Deplano, Daniele Loco, Boris Sattarov, Florent Hédin, Sebastian Wendeborn, Chris Ho, Dina El Ahdab, Theo Jaffrelot Inizan, Mattia Sturlese, Alice Sosic, Martina Volpiana, Angela Lugato, Marco Barone, Barbara Gatto, Maria Ludovica Macchia, Massimo Bellanda, Roberto Battistutta, Cristiano Salata, Ivan Kondratov, Rustam Iminov, Andrii Khairulin, Yaroslav Mykhalonok, Anton Pochepko, Volodymyr Chashka-Ratushnyi, Iaroslava Kos, Stefano Moro, Matthieu Montes, Pengyu Ren, Jay W. Ponder, Louis Lagardère, Jean-Philip Piquemal, Davide Sabbadin
Publikováno v:
Chemical Science
Chemical Science, 2022, ⟨10.1039/D1SC05892D⟩
Chemical Science, 2022, ⟨10.1039/D1SC05892D⟩
We report a fast-track computationally-driven discovery of new SARS-CoV2 Main Protease (Mpro) inhibitors whose potency range from mM for initial non-covalent ligands to high nM for the final covalent compound (IC50=830 +/- 50 nM). The project extensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fb3c770ad5b156560e839423dea37d
https://hal.science/hal-03361062
https://hal.science/hal-03361062
Autor:
Léa, El Khoury, Zhifeng, Jing, Alberto, Cuzzolin, Alessandro, Deplano, Daniele, Loco, Boris, Sattarov, Florent, Hédin, Sebastian, Wendeborn, Chris, Ho, Dina, El Ahdab, Theo, Jaffrelot Inizan, Mattia, Sturlese, Alice, Sosic, Martina, Volpiana, Angela, Lugato, Marco, Barone, Barbara, Gatto, Maria Ludovica, Macchia, Massimo, Bellanda, Roberto, Battistutta, Cristiano, Salata, Ivan, Kondratov, Rustam, Iminov, Andrii, Khairulin, Yaroslav, Mykhalonok, Anton, Pochepko, Volodymyr, Chashka-Ratushnyi, Iaroslava, Kos, Stefano, Moro, Matthieu, Montes, Pengyu, Ren, Jay W, Ponder, Louis, Lagardère, Jean-Philip, Piquemal, Davide, Sabbadin
Publikováno v:
Chemical science. 13(13)
We report a fast-track computationally driven discovery of new SARS-CoV-2 main protease (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09aa3a22bcf963a31ded78c4b6b5bf9a
https://pubmed.ncbi.nlm.nih.gov/35432906
https://pubmed.ncbi.nlm.nih.gov/35432906
Autor:
Fornasier, Emanuele1 (AUTHOR), Macchia, Maria Ludovica2 (AUTHOR), Giachin, Gabriele1 (AUTHOR), Sosic, Alice2 (AUTHOR), Pavan, Matteo3 (AUTHOR), Sturlese, Mattia3 (AUTHOR), Salata, Cristiano4 (AUTHOR), Moro, Stefano3 (AUTHOR), Gatto, Barbara2 (AUTHOR), Bellanda, Massimo1,5 (AUTHOR), Battistutta, Roberto1,5 (AUTHOR) roberto.battistutta@unipd.it
Publikováno v:
Acta Crystallographica: Section D, Structural Biology. Mar2022, Vol. 78 Issue 3, p363-378. 16p.
Publikováno v:
Dalton Transactions: An International Journal of Inorganic Chemistry; 1/28/2024, Vol. 53 Issue 4, p1359-1372, 14p
Autor:
Travagin, Fabio, Macchia, Maria Ludovica, Grell, Toni, Bodnár, Judit, Baranyai, Zsolt, Artizzu, Flavia, Botta, Mauro, Giovenzana, Giovanni B.
Publikováno v:
Dalton Transactions: An International Journal of Inorganic Chemistry; 1/28/2024, Vol. 53 Issue 4, p1779-1793, 15p
Publikováno v:
Chemical Science; 4/7/2022, Vol. 13 Issue 13, p3615-3624, 10p
Autor:
El Khoury, Léa, Jing, Zhifeng, Cuzzolin, Alberto, Deplano, Alessandro, Loco, Daniele, Sattarov, Boris, Hédin, Florent, Wendeborn, Sebastian, Ho, Chris, El Ahdab, Dina, Jaffrelot Inizan, Theo, Sturlese, Mattia, Sosic, Alice, Volpiana, Martina, Lugato, Angela, Barone, Marco, Gatto, Barbara, Macchia, Maria Ludovica, Bellanda, Massimo, Battistutta, Roberto
Publikováno v:
Chemical Science; 4/7/2022, Vol. 13 Issue 13, p3674-3687, 14p