Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Maria Lucia S. Güther"'
Autor:
Michele Tinti, Maria Lucia S. Güther, Thomas W. M. Crozier, Angus I. Lamond, Michael A. J. Ferguson
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
Background: Cellular proteins vary significantly in both abundance and turnover rates. These parameters depend upon their rates of synthesis and degradation and it is useful to have access to data on protein turnover rates when, for example, designin
Externí odkaz:
https://doaj.org/article/b1716ed1b9624d2eb356fb14dd688c86
Autor:
Ian H. Gilbert, Susan Wyllie, Michael A. J. Ferguson, Sandra Carvalho, Eoin Moynihan, Fabio Zuccotto, Maria Lucia S. Güther, Davide Bello, Giulia Chemi, Richard J. Wall, Alan H. Fairlamb, Luciana S. Paradela, Julio Martin, Stephen Patterson, Victoriano Corpas-López
Publikováno v:
Cell Chemical Biology
Summary Phenotypic screening identified a benzothiophene compound with activity against Leishmania donovani, the causative agent of visceral leishmaniasis. Using multiple orthogonal approaches, oxidosqualene cyclase (OSC), a key enzyme of sterol bios
Autor:
Angela Mehlert, Sebastian Damerow, Stephen M. Beverley, Hongjie Guo, Giulia Bandini, Maria Lucia S. Güther, Michael A. J. Ferguson
Fucose is a common component of eukaryotic cell-surface glycoconjugates, generally added by Golgi-resident fucosyltransferases. Whereas fucosylated glycoconjugates are rare in kinetoplastids, the biosynthesis of the nucleotide sugar GDP-Fuc has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54f8717fd93f64990a8cf8b058bf78f5
https://doi.org/10.1101/726117
https://doi.org/10.1101/726117
Autor:
Sabine Kuettel, Michele Tinti, Michael A. J. Ferguson, Alan R. Prescott, Maria Lucia S. Güther
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 2, p e0009132 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
In Trypanosoma brucei, there are fourteen enzymatic biotransformations that collectively convert glucose into five essential nucleotide sugars: UDP-Glc, UDP-Gal, UDP-GlcNAc, GDP-Man and GDP-Fuc. These biotransformations are catalyzed by thirteen disc
Publikováno v:
The Journal of Biological Chemistry
Trypanosoma brucei causes African trypanosomiasis and contains three full-length oligosaccharyltransferase (OST) genes; two of which, TbSTT3A and TbSTT3B, are expressed in the bloodstream form of the parasite. These OSTs have different peptide accept
Autor:
Michael A. J. Ferguson, Maria Lucia S. Güther, Thomas W M Crozier, Michele Tinti, Angus I. Lamond
Publikováno v:
Wellcome Open Research. 4:152
Background: Cellular proteins vary significantly in both abundance and turnover rates. These parameters depend upon their rates of synthesis and degradation and it is useful to have access to data on protein turnover rates when, for example, designin
Autor:
Sabine Kuettel, Maria Lucia S. Güther, Carolin Riemer, Michael A. J. Ferguson, Majken C. T. Wadum, Karina Mariño
Publikováno v:
Molecular Microbiology
Summary The sugar nucleotide GDP-mannose is essential for Trypanosoma brucei. Phosphomannose isomerase occupies a key position on the de novo pathway to GDP-mannose from glucose, just before intersection with the salvage pathway from free mannose. We
Autor:
Mernhaz Amani, Amy K. Wernimont, Karina Mariño, Michael A. J. Ferguson, Maria Lucia S. Güther, Raymond Hui
Publikováno v:
Glycobiology
The protozoan parasite Trypanosoma brucei is the causative agent of the cattle disease Nagana and human African sleeping sickness. Glycoproteins play key roles in the parasite's survival and infectivity, and the de novo biosyntheses of the sugar nucl
Publikováno v:
Biochemical Journal. 391:425-432
Trypanothione plays a pivotal role in defence against chemical and oxidant stress, thiol redox homoeostasis, ribonucleotide metabolism and drug resistance in parasitic kinetoplastids. In Trypanosoma brucei, trypanothione is synthesized from glutathio
Publikováno v:
Proceedings of the National Academy of Sciences. 99:5884-5889
The tsetse fly-transmitted protozoan parasite Trypanosoma brucei is the causative agent of human African sleeping sickness and the cattle disease Nagana. The bloodstream form of the parasite uses a dense cell-surface coat of variant surface glycoprot