Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Maria Lindahl"'
Autor:
Jenni E. Anttila, Olli S. Mattila, Hock-Kean Liew, Kert Mätlik, Eero Mervaala, Päivi Lindholm, Maria Lindahl, Perttu J. Lindsberg, Kuan-Yin Tseng, Mikko Airavaara
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-24 (2024)
Abstract Mesencephalic astrocyte-derived neurotrophic factor (MANF) has cytoprotective effects on various injuries, including cerebral ischemia, and it can promote recovery even when delivered intracranially several days after ischemic stroke. In the
Externí odkaz:
https://doaj.org/article/cd3742bb5b894f548ea64724f99c629c
Autor:
Yeawon Kim, Chuang Li, Chenjian Gu, Yili Fang, Eric Tycksen, Anuradhika Puri, Terri A. Pietka, Jothilingam Sivapackiam, Kendrah Kidd, Sun-Ji Park, Bryce G. Johnson, Stanislav Kmoch, Jeremy S. Duffield, Anthony J. Bleyer, Meredith E. Jackrel, Fumihiko Urano, Vijay Sharma, Maria Lindahl, Ying Maggie Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Misfolded protein aggregates may cause toxic proteinopathy, including autosomal dominant tubulointerstitial kidney disease due to uromodulin mutations (ADTKD-UMOD), a leading hereditary kidney disease. There are no targeted therapies. In our
Externí odkaz:
https://doaj.org/article/72c2d4d2fcd54509bc61bc5046fee857
Autor:
Kuan-Yin Tseng, Vassilis Stratoulias, Wei-Fen Hu, Jui-Sheng Wu, Vicki Wang, Yuan-Hao Chen, Anna Seelbach, Henri J. Huttunen, Natalia Kulesskaya, Cheng-Yoong Pang, Jian-Liang Chou, Maria Lindahl, Mart Saarma, Li-Chuan Huang, Mikko Airavaara, Hock-Kean Liew
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-20 (2023)
Abstract During intracerebral hemorrhage (ICH), hematoma formation at the site of blood vessel damage results in local mechanical injury. Subsequently, erythrocytes lyse to release hemoglobin and heme, which act as neurotoxins and induce inflammation
Externí odkaz:
https://doaj.org/article/e5091f6de8f64d6aa9ee0c7414b369b1
Autor:
Maryna Koskela, T. Petteri Piepponen, Maria Lindahl, Brandon K. Harvey, Jaan-Olle Andressoo, Vootele Võikar, Mikko Airavaara
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-17 (2021)
Abstract Background Craving for alcohol, in other words powerful desire to drink after withdrawal, is an important contributor to the development and maintenance of alcoholism. Here, we studied the role of GDNF (glial cell line-derived neurotrophic f
Externí odkaz:
https://doaj.org/article/02e01585df47494e9bba26c02a845904
Autor:
L. Lauriina Porokuokka, Heikki T. Virtanen, Jere Lindén, Yulia Sidorova, Tatiana Danilova, Maria Lindahl, Mart Saarma, Jaan-Olle Andressoo
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 3, Pp 655-678 (2019)
Background & Aims: RET, the receptor for the glial cell line–derived neurotrophic factor (GDNF) family ligands, is the most frequently mutated gene in congenital aganglionic megacolon or Hirschsprung’s disease (HSCR). The leading cause of mortali
Externí odkaz:
https://doaj.org/article/4093d27634394fabbd2090d68e2d8c5b
Autor:
Takuya Yagi, Rie Asada, Kohsuke Kanekura, Ave Eesmaa, Maria Lindahl, Mart Saarma, Fumihiko Urano
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101810- (2020)
Summary: Endoplasmic reticulum (ER) stress is known to induce pro-inflammatory response and ultimately leads to cell death. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an ER-localized protein whose expression and secretion is induce
Externí odkaz:
https://doaj.org/article/45fd4ed484f446d8996fccda110cb797
Autor:
Maria Lindahl, Alcmène Chalazonitis, Erik Palm, Emmi Pakarinen, Tatiana Danilova, Tuan D. Pham, Wanda Setlik, Meenakshi Rao, Vootele Võikar, Jatta Huotari, Jaakko Kopra, Jaan-Olle Andressoo, Petteri T. Piepponen, Mikko Airavaara, Anne Panhelainen, Michael D. Gershon, Mart Saarma
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Cerebral dopamine neurotrophic factor (CDNF) is neuroprotective for nigrostriatal dopamine neurons and restores dopaminergic function in animal models of Parkinson's disease (PD). To understand the role of CDNF in mammals, we generated CDNF knockout
Externí odkaz:
https://doaj.org/article/69ba4e0c23f74002a965644692bf2a73
Publikováno v:
Neurobiology of Disease, Vol 97, Iss , Pp 90-102 (2017)
Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived neurotrophic factor (MANF) promote the survival of midbrain dopaminergic neurons which degenerate in Parkinson's disease (PD). However, CDNF and MANF are structurally an
Externí odkaz:
https://doaj.org/article/3b8ae70812f149bca90dad546b2a5e2b
Autor:
Tatiana Danilova, Emilia Galli, Emmi Pakarinen, Erik Palm, Päivi Lindholm, Mart Saarma, Maria Lindahl
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine neurotrophic factor (CDNF) form a family of atypical growth factors discovered for their neuroprotective properties in the central nervous system (CNS) in animal models
Externí odkaz:
https://doaj.org/article/8030f1f6315340aba45a979396c93b13
Autor:
Maria Lindahl, Jitka Petrlova, Jonathan Dalla-Riva, Sebastian Wasserstrom, Catarina Rippe, Joan Domingo-Espin, Dorota Kotowska, Ewa Krupinska, Christine Berggreen, Helena A. Jones, Karl Swärd, Jens O. Lagerstedt, Olga Göransson, Karin G. Stenkula
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 12, Pp 2248-2259 (2015)
ApoA-I, the main protein component of HDL, is suggested to be involved in metabolic homeostasis. We examined the effects of Milano, a naturally occurring ApoA-I variant, about which little mechanistic information is available. Remarkably, high-fat-fe
Externí odkaz:
https://doaj.org/article/0aa81832a4b14fbda3c35032f37a5812